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Gene · 6328

SCN3A: sodium voltage-gated channel alpha subunit 3

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SCN3A: sodium voltage-gated channel alpha subunit 3. Genes, record 6328. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6328

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Gene

Symbol
SCN3A
HGNC
Name
sodium voltage-gated channel alpha subunit 3
HGNC
NCBI Gene ID
6328
NCBI Gene
HGNC ID
HGNC:10590
HGNC
Ensembl
ENSG00000153253
NCBI Gene
Aliases
DEE62, EIEE62, FFEVF4, NAC3, Nav1.3
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9NY46Sodium channel protein type 3 subunit alpha2,0002Ensembl, GeneID, HGNC

Source UniProt

Patents22

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1463896Q9NY46Espacenet
US 12516308 B22026-01-062438Q9NY46Espacenet
EP 4641201 A22025-10-297804Q9NY46Espacenet
JP 2025529142 A2025-09-043844Q9NY46Espacenet
US 12371689 B22025-07-293844Q9NY46Espacenet
JP 2025517969 A2025-06-127804Q9NY46Espacenet
JP 2024520478 A2024-05-2430Q9NY46Espacenet
US 11898179 B22024-02-132438Q9NY46Espacenet
US 11464217 B22022-10-1123Q9NY46Espacenet
US 11446398 B22022-09-2080221Q9NY46Espacenet

1 to 10 of 22

See all 22 patents

Drugs84

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ARTICAINECHEMBL1093Sodium channel alpha subunit blockerBLOCKERChEMBL
ARTICAINE HYDROCHLORIDECHEMBL1200819Sodium channel alpha subunit blockerBLOCKERChEMBL
BENOXINATECHEMBL1200Sodium channel alpha subunit blockerBLOCKERChEMBL
BENOXINATE HYDROCHLORIDECHEMBL1200654Sodium channel alpha subunit blockerBLOCKERChEMBL
CARBAMAZEPINECHEMBL108Sodium channel alpha subunit blockerBLOCKERChEMBL
CENOBAMATECHEMBL3989949Sodium channel alpha subunit inhibitorINHIBITORChEMBL
CHLOROPROCAINECHEMBL1179047Sodium channel alpha subunit blockerBLOCKERChEMBL
CHLOROPROCAINE HYDROCHLORIDECHEMBL944Sodium channel alpha subunit blockerBLOCKERChEMBL
COCAINECHEMBL370805Sodium channel alpha subunit blockerBLOCKERChEMBL
COCAINE HYDROCHLORIDECHEMBL529437Sodium channel alpha subunit blockerBLOCKERChEMBL

1 to 10 of 84

See all 84 drugs

Trials1,301

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants843

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSCN3A papersNewest fiscal year
R01NS034509Functional Genetics of the Neuronal Sodium Channel Gene SCN8A122025
UL1TR001863Yale Clinical and Translational Science Award42025
R01NS032457Cell Identity Determination in Human Brain: Somatic Mutation and Cell Lineage32025
T32HL007853Multidisciplinary Cardiovascular Research Training32025
T32MH065215Postdoctoral Program in Functional Neurogenomics32025
U24NS120854ClinGen Expert Curation Panel for the Epilepsies32025
I01BX003362Genetics of Cardiometabolic Diseases in the VA Population22025
P30AI027763UCSF-Bay Area Center for AIDS Research22025
P30CA008748Cancer Center Support Grant22025
P30DK116074Stanford Diabetes Research Center22025

1 to 10 of 843Source NIH's project files

See all 843 nih grants

Papers1,322

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Genetically predicted triglyceride levels and endometriosis risk: Mendelian randomization with exploratory multi-omics analyses.PLoS One202642594068PubTator, text miningPubMed
Painful neuromas exhibit axonal phenotypic shift via nociceptive and mechanosensitive marker up-regulation.PNAS Nexus202642582843PubTator, text miningPubMed
A Multi-Method Approach to Investigate the Toxicity of Aristolochic Acid on Upper Tract Urothelial Carcinoma.Curr Med Chem202642565416PubTator, text miningPubMed
Differential Na+ chelation underlies opposite effects of aconitine and bulleyaconitine on sodium channel permeation.J Gen Physiol202642560360PubTator, text miningPubMed
An Adult Presentation of KIF11-Related MCLID Syndrome: Case Report and 40-Year Follow-Up.Am J Med Genet A202642552906PubTator, text miningPubMed
Sodium ion channels as therapeutic targets in epilepsy: a drug discovery perspective.Bioorg Chem202642508198PubTator, text miningPubMed
Seizure freedom after vagus nerve stimulation in a patient with SCN3A-related network epilepsy and incomplete penetrance: A case report.Epilepsy Behav Rep202642471838PubTator, text miningPubMed
CRISPR/Cas9-mediated PHOX2B functional knock-out in IMR32 neuroblastoma cells impairs neuronal excitability through dysregulation of ion channels genes.Front Physiol202642422362PubTator, text miningPubMed
Evolution, hibernation, and inactivation of voltage-gated Na channels.J Gen Physiol202642412989PubTator, text miningPubMed
ACMG/AMP variant classification specifications from the ClinGen Epilepsy Sodium Channel Variant Curation Expert Panel.Genet Med202642227234PubTator, text miningPubMed

1 to 10 of 1,322

See all 1,322 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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