Gene · 6328
SCN3A: sodium voltage-gated channel alpha subunit 3
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. SCN3A: sodium voltage-gated channel alpha subunit 3. Genes, record 6328. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6328
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9NY46 | Sodium channel protein type 3 subunit alpha | 2,000 | 2 | Ensembl, GeneID, HGNC |
Source UniProt
Patents22
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 63896 | Q9NY46 | Espacenet |
| US 12516308 B2 | 2026-01-06 | 2438 | Q9NY46 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 7804 | Q9NY46 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 3844 | Q9NY46 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 3844 | Q9NY46 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 7804 | Q9NY46 | Espacenet |
| JP 2024520478 A | 2024-05-24 | 30 | Q9NY46 | Espacenet |
| US 11898179 B2 | 2024-02-13 | 2438 | Q9NY46 | Espacenet |
| US 11464217 B2 | 2022-10-11 | 23 | Q9NY46 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 80221 | Q9NY46 | Espacenet |
1 to 10 of 22
See all 22 patentsDrugs84
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| ARTICAINE | CHEMBL1093 | Sodium channel alpha subunit blocker | BLOCKER | ChEMBL |
| ARTICAINE HYDROCHLORIDE | CHEMBL1200819 | Sodium channel alpha subunit blocker | BLOCKER | ChEMBL |
| BENOXINATE | CHEMBL1200 | Sodium channel alpha subunit blocker | BLOCKER | ChEMBL |
| BENOXINATE HYDROCHLORIDE | CHEMBL1200654 | Sodium channel alpha subunit blocker | BLOCKER | ChEMBL |
| CARBAMAZEPINE | CHEMBL108 | Sodium channel alpha subunit blocker | BLOCKER | ChEMBL |
| CENOBAMATE | CHEMBL3989949 | Sodium channel alpha subunit inhibitor | INHIBITOR | ChEMBL |
| CHLOROPROCAINE | CHEMBL1179047 | Sodium channel alpha subunit blocker | BLOCKER | ChEMBL |
| CHLOROPROCAINE HYDROCHLORIDE | CHEMBL944 | Sodium channel alpha subunit blocker | BLOCKER | ChEMBL |
| COCAINE | CHEMBL370805 | Sodium channel alpha subunit blocker | BLOCKER | ChEMBL |
| COCAINE HYDROCHLORIDE | CHEMBL529437 | Sodium channel alpha subunit blocker | BLOCKER | ChEMBL |
1 to 10 of 84
See all 84 drugsTrials1,301
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07599800 | LIDOCAINE | PHASE2/PHASE3 | ClinicalTrials.gov | |
| NCT07592143 | LIDOCAINE | PHASE3 | ClinicalTrials.gov | |
| NCT07588750 | TOPIRAMATE | ClinicalTrials.gov | ||
| NCT07572994 | LIDOCAINE | ClinicalTrials.gov | ||
| NCT07568496 | LIDOCAINE | ClinicalTrials.gov | ||
| NCT07547371 | ARTICAINE HYDROCHLORIDE | ClinicalTrials.gov | ||
| NCT07546370 | PRILOCAINE | PHASE4 | ClinicalTrials.gov | |
| NCT07546370 | LIDOCAINE | PHASE4 | ClinicalTrials.gov | |
| NCT07536594 | LIDOCAINE | ClinicalTrials.gov | ||
| NCT07511400 | LIDOCAINE | EARLY_PHASE1 | ClinicalTrials.gov |
1 to 10 of 1,301
See all 1,301 trialsNIH grants843
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | SCN3A papers | Newest fiscal year |
|---|---|---|---|
| R01NS034509 | Functional Genetics of the Neuronal Sodium Channel Gene SCN8A | 12 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 4 | 2025 |
| R01NS032457 | Cell Identity Determination in Human Brain: Somatic Mutation and Cell Lineage | 3 | 2025 |
| T32HL007853 | Multidisciplinary Cardiovascular Research Training | 3 | 2025 |
| T32MH065215 | Postdoctoral Program in Functional Neurogenomics | 3 | 2025 |
| U24NS120854 | ClinGen Expert Curation Panel for the Epilepsies | 3 | 2025 |
| I01BX003362 | Genetics of Cardiometabolic Diseases in the VA Population | 2 | 2025 |
| P30AI027763 | UCSF-Bay Area Center for AIDS Research | 2 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 2 | 2025 |
| P30DK116074 | Stanford Diabetes Research Center | 2 | 2025 |
1 to 10 of 843Source NIH's project files
See all 843 nih grantsPapers1,322
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Genetically predicted triglyceride levels and endometriosis risk: Mendelian randomization with exploratory multi-omics analyses. | PLoS One | 2026 | 42594068 | PubTator, text mining | PubMed |
| Painful neuromas exhibit axonal phenotypic shift via nociceptive and mechanosensitive marker up-regulation. | PNAS Nexus | 2026 | 42582843 | PubTator, text mining | PubMed |
| A Multi-Method Approach to Investigate the Toxicity of Aristolochic Acid on Upper Tract Urothelial Carcinoma. | Curr Med Chem | 2026 | 42565416 | PubTator, text mining | PubMed |
| Differential Na+ chelation underlies opposite effects of aconitine and bulleyaconitine on sodium channel permeation. | J Gen Physiol | 2026 | 42560360 | PubTator, text mining | PubMed |
| An Adult Presentation of KIF11-Related MCLID Syndrome: Case Report and 40-Year Follow-Up. | Am J Med Genet A | 2026 | 42552906 | PubTator, text mining | PubMed |
| Sodium ion channels as therapeutic targets in epilepsy: a drug discovery perspective. | Bioorg Chem | 2026 | 42508198 | PubTator, text mining | PubMed |
| Seizure freedom after vagus nerve stimulation in a patient with SCN3A-related network epilepsy and incomplete penetrance: A case report. | Epilepsy Behav Rep | 2026 | 42471838 | PubTator, text mining | PubMed |
| CRISPR/Cas9-mediated PHOX2B functional knock-out in IMR32 neuroblastoma cells impairs neuronal excitability through dysregulation of ion channels genes. | Front Physiol | 2026 | 42422362 | PubTator, text mining | PubMed |
| Evolution, hibernation, and inactivation of voltage-gated Na channels. | J Gen Physiol | 2026 | 42412989 | PubTator, text mining | PubMed |
| ACMG/AMP variant classification specifications from the ClinGen Epilepsy Sodium Channel Variant Curation Expert Panel. | Genet Med | 2026 | 42227234 | PubTator, text mining | PubMed |
1 to 10 of 1,322
See all 1,322 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/6328
GET https://conductscience.org/api/genes/v1/6328/patents?page=2