Gene · 6332
SCN7A: sodium voltage-gated channel alpha subunit 7
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. SCN7A: sodium voltage-gated channel alpha subunit 7. Genes, record 6332. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6332
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q01118 | Sodium channel protein type 7 subunit alpha | 1,682 | 2 | Ensembl, GeneID, HGNC |
Source UniProt
Patents32
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 63925 | Q01118 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 63926 | Q01118 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 13243 | Q01118 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 15022 | Q01118 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 22793 | Q01118 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 23203 | Q01118 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 3849 | Q01118 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 3849 | Q01118 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 15022 | Q01118 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 22793 | Q01118 | Espacenet |
1 to 10 of 32
See all 32 patentsDrugs83
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| ARTICAINE | CHEMBL1093 | Sodium channel alpha subunit blocker | BLOCKER | ChEMBL |
| ARTICAINE HYDROCHLORIDE | CHEMBL1200819 | Sodium channel alpha subunit blocker | BLOCKER | ChEMBL |
| BENOXINATE | CHEMBL1200 | Sodium channel alpha subunit blocker | BLOCKER | ChEMBL |
| BENOXINATE HYDROCHLORIDE | CHEMBL1200654 | Sodium channel alpha subunit blocker | BLOCKER | ChEMBL |
| CARBAMAZEPINE | CHEMBL108 | Sodium channel alpha subunit blocker | BLOCKER | ChEMBL |
| CENOBAMATE | CHEMBL3989949 | Sodium channel alpha subunit inhibitor | INHIBITOR | ChEMBL |
| CHLOROPROCAINE | CHEMBL1179047 | Sodium channel alpha subunit blocker | BLOCKER | ChEMBL |
| CHLOROPROCAINE HYDROCHLORIDE | CHEMBL944 | Sodium channel alpha subunit blocker | BLOCKER | ChEMBL |
| COCAINE | CHEMBL370805 | Sodium channel alpha subunit blocker | BLOCKER | ChEMBL |
| COCAINE HYDROCHLORIDE | CHEMBL529437 | Sodium channel alpha subunit blocker | BLOCKER | ChEMBL |
1 to 10 of 83
See all 83 drugsTrials1,301
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07599800 | LIDOCAINE | PHASE2/PHASE3 | ClinicalTrials.gov | |
| NCT07592143 | LIDOCAINE | PHASE3 | ClinicalTrials.gov | |
| NCT07588750 | TOPIRAMATE | ClinicalTrials.gov | ||
| NCT07572994 | LIDOCAINE | ClinicalTrials.gov | ||
| NCT07568496 | LIDOCAINE | ClinicalTrials.gov | ||
| NCT07547371 | ARTICAINE HYDROCHLORIDE | ClinicalTrials.gov | ||
| NCT07546370 | PRILOCAINE | PHASE4 | ClinicalTrials.gov | |
| NCT07546370 | LIDOCAINE | PHASE4 | ClinicalTrials.gov | |
| NCT07536594 | LIDOCAINE | ClinicalTrials.gov | ||
| NCT07511400 | LIDOCAINE | EARLY_PHASE1 | ClinicalTrials.gov |
1 to 10 of 1,301
See all 1,301 trialsNIH grants358
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | SCN7A papers | Newest fiscal year |
|---|---|---|---|
| P30CA068485 | Cancer Center Support Grant | 2 | 2025 |
| P30EY008126 | Core Grant in Vision Research | 2 | 2025 |
| P30EY025580 | Multidisciplinary Investigations in Visual Science | 2 | 2025 |
| P50DC000422 | Experimental and Clinical Studies of Presbyacusis Extension and Supplement | 2 | 2025 |
| R01EY024605 | Choriocapillaris Protection and Replacement in AMD | 2 | 2025 |
| T32NS007473 | Developmental Neurology | 2 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 2 | 2025 |
| I01BX000638 | Pathogenesis of Nerve Injury: Role of Tissue Inhibitor of Metalloproteinases-1 | 1 | 2025 |
| I01CX002291 | Understanding Myocardial Recovery in Diabetes and Heart Failure | 1 | 2025 |
| K12EY016335 | Harvard-Vision Clinical Scientist Development Program | 1 | 2025 |
1 to 10 of 358Source NIH's project files
See all 358 nih grantsPapers461
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Information-driven nanozyme screening enabled sensitive detection of seminal neutral α-glucosidase activity reveals clinical infertility relevance. | Biosens Bioelectron | 2026 | 42664939 | PubTator, text mining | PubMed |
| Cenobamate use in super-refractory status epilepticus: A report of three cases. | Epileptic Disord | 2026 | 42400400 | PubTator, text mining | PubMed |
| Self-limited neonatal epilepsy with 2q24.3 duplications: Case series and literature review. | Epileptic Disord | 2026 | 42017391 | PubTator, text mining | PubMed |
| Unveiling lactylation: A novel frontier in the pathogenesis of diabetic nephropathy (Review). | Int J Mol Med | 2026 | 41891971 | PubTator, text mining | PubMed |
| Alternative splicing in voltage-gated sodium channels: mechanisms, regulatory networks and therapeutic implications. | Ann Med | 2026 | 41869747 | PubTator, text mining | PubMed |
| CAR-T cells targeting activated hepatic stellate cells ameliorate liver fibrosis in mouse models. | JHEP Rep | 2026 | 41810431 | PubTator, text mining | PubMed |
| Single-cell multi-omic techniques highlight the diverse composition and intercellular interactions of the vestibular schwannoma tumor microenvironment. | Neurooncol Adv | 2026 | 41769413 | PubTator, text mining | PubMed |
| Identification of antidepressant response-related changes to DNA methylation and gene expression. | Int J Neuropsychopharmacol | 2026 | 41593764 | PubTator, text mining | PubMed |
| Efficacy of Dravet Syndrome Treatments in a Subset of Individuals with 2q24.3 Deletion: A-5 Patient Case Series. | J Child Neurol | 2026 | 41564166 | PubTator, text mining | PubMed |
| Advancements in early biomarkers of acute kidney injury: from traditional indicators to a paradigm shift in lactate metabolism. | Ann Med | 2026 | 41530927 | PubTator, text mining | PubMed |
1 to 10 of 461
See all 461 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/6332
GET https://conductscience.org/api/genes/v1/6332/patents?page=2