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Gene · 6332

SCN7A: sodium voltage-gated channel alpha subunit 7

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SCN7A: sodium voltage-gated channel alpha subunit 7. Genes, record 6332. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6332

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Gene

Symbol
SCN7A
HGNC
Name
sodium voltage-gated channel alpha subunit 7
HGNC
NCBI Gene ID
6332
NCBI Gene
HGNC ID
HGNC:10594
HGNC
Ensembl
ENSG00000136546
NCBI Gene
Aliases
NaG, Nav2.1, Nav2.2, SCN6A
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q01118Sodium channel protein type 7 subunit alpha1,6822Ensembl, GeneID, HGNC

Source UniProt

Patents32

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1463925Q01118Espacenet
JP 2026004568 A2026-01-1463926Q01118Espacenet
EP 4650780 A22025-11-1913243Q01118Espacenet
EP 4641201 A22025-10-2915022Q01118Espacenet
EP 4641201 A22025-10-2922793Q01118Espacenet
EP 4641201 A22025-10-2923203Q01118Espacenet
JP 2025529142 A2025-09-043849Q01118Espacenet
US 12371689 B22025-07-293849Q01118Espacenet
JP 2025517969 A2025-06-1215022Q01118Espacenet
JP 2025517969 A2025-06-1222793Q01118Espacenet

1 to 10 of 32

See all 32 patents

Drugs83

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ARTICAINECHEMBL1093Sodium channel alpha subunit blockerBLOCKERChEMBL
ARTICAINE HYDROCHLORIDECHEMBL1200819Sodium channel alpha subunit blockerBLOCKERChEMBL
BENOXINATECHEMBL1200Sodium channel alpha subunit blockerBLOCKERChEMBL
BENOXINATE HYDROCHLORIDECHEMBL1200654Sodium channel alpha subunit blockerBLOCKERChEMBL
CARBAMAZEPINECHEMBL108Sodium channel alpha subunit blockerBLOCKERChEMBL
CENOBAMATECHEMBL3989949Sodium channel alpha subunit inhibitorINHIBITORChEMBL
CHLOROPROCAINECHEMBL1179047Sodium channel alpha subunit blockerBLOCKERChEMBL
CHLOROPROCAINE HYDROCHLORIDECHEMBL944Sodium channel alpha subunit blockerBLOCKERChEMBL
COCAINECHEMBL370805Sodium channel alpha subunit blockerBLOCKERChEMBL
COCAINE HYDROCHLORIDECHEMBL529437Sodium channel alpha subunit blockerBLOCKERChEMBL

1 to 10 of 83

See all 83 drugs

Trials1,301

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants358

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSCN7A papersNewest fiscal year
P30CA068485Cancer Center Support Grant22025
P30EY008126Core Grant in Vision Research22025
P30EY025580Multidisciplinary Investigations in Visual Science22025
P50DC000422Experimental and Clinical Studies of Presbyacusis Extension and Supplement22025
R01EY024605Choriocapillaris Protection and Replacement in AMD22025
T32NS007473Developmental Neurology22025
UL1TR001863Yale Clinical and Translational Science Award22025
I01BX000638Pathogenesis of Nerve Injury: Role of Tissue Inhibitor of Metalloproteinases-112025
I01CX002291Understanding Myocardial Recovery in Diabetes and Heart Failure12025
K12EY016335Harvard-Vision Clinical Scientist Development Program12025

1 to 10 of 358Source NIH's project files

See all 358 nih grants

Papers461

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Information-driven nanozyme screening enabled sensitive detection of seminal neutral α-glucosidase activity reveals clinical infertility relevance.Biosens Bioelectron202642664939PubTator, text miningPubMed
Cenobamate use in super-refractory status epilepticus: A report of three cases.Epileptic Disord202642400400PubTator, text miningPubMed
Self-limited neonatal epilepsy with 2q24.3 duplications: Case series and literature review.Epileptic Disord202642017391PubTator, text miningPubMed
Unveiling lactylation: A novel frontier in the pathogenesis of diabetic nephropathy (Review).Int J Mol Med202641891971PubTator, text miningPubMed
Alternative splicing in voltage-gated sodium channels: mechanisms, regulatory networks and therapeutic implications.Ann Med202641869747PubTator, text miningPubMed
CAR-T cells targeting activated hepatic stellate cells ameliorate liver fibrosis in mouse models.JHEP Rep202641810431PubTator, text miningPubMed
Single-cell multi-omic techniques highlight the diverse composition and intercellular interactions of the vestibular schwannoma tumor microenvironment.Neurooncol Adv202641769413PubTator, text miningPubMed
Identification of antidepressant response-related changes to DNA methylation and gene expression.Int J Neuropsychopharmacol202641593764PubTator, text miningPubMed
Efficacy of Dravet Syndrome Treatments in a Subset of Individuals with 2q24.3 Deletion: A-5 Patient Case Series.J Child Neurol202641564166PubTator, text miningPubMed
Advancements in early biomarkers of acute kidney injury: from traditional indicators to a paradigm shift in lactate metabolism.Ann Med202641530927PubTator, text miningPubMed

1 to 10 of 461

See all 461 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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