Gene · 6334
SCN8A: sodium voltage-gated channel alpha subunit 8
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. SCN8A: sodium voltage-gated channel alpha subunit 8. Genes, record 6334. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6334
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9UQD0 | Sodium channel protein type 8 subunit alpha | 1,980 | 7 | Ensembl, GeneID, HGNC |
Source UniProt
Patents46
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 63878 | Q9UQD0 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 6963 | Q9UQD0 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 3850 | Q9UQD0 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 3850 | Q9UQD0 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 6963 | Q9UQD0 | Espacenet |
| JP 2024520478 A | 2024-05-24 | 33 | Q9UQD0 | Espacenet |
| JP 2023548973 A | 2023-11-21 | 235 | Q9UQD0 | Espacenet |
| US 11464217 B2 | 2022-10-11 | 26 | Q9UQD0 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 80256 | Q9UQD0 | Espacenet |
| US 11400116 B2 | 2022-08-02 | 3879 | Q9UQD0 | Espacenet |
1 to 10 of 46
See all 46 patentsDrugs84
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| ARTICAINE | CHEMBL1093 | Sodium channel alpha subunit blocker | BLOCKER | ChEMBL |
| ARTICAINE HYDROCHLORIDE | CHEMBL1200819 | Sodium channel alpha subunit blocker | BLOCKER | ChEMBL |
| BENOXINATE | CHEMBL1200 | Sodium channel alpha subunit blocker | BLOCKER | ChEMBL |
| BENOXINATE HYDROCHLORIDE | CHEMBL1200654 | Sodium channel alpha subunit blocker | BLOCKER | ChEMBL |
| CARBAMAZEPINE | CHEMBL108 | Sodium channel alpha subunit blocker | BLOCKER | ChEMBL |
| CENOBAMATE | CHEMBL3989949 | Sodium channel alpha subunit inhibitor | INHIBITOR | ChEMBL |
| CHLOROPROCAINE | CHEMBL1179047 | Sodium channel alpha subunit blocker | BLOCKER | ChEMBL |
| CHLOROPROCAINE HYDROCHLORIDE | CHEMBL944 | Sodium channel alpha subunit blocker | BLOCKER | ChEMBL |
| COCAINE | CHEMBL370805 | Sodium channel alpha subunit blocker | BLOCKER | ChEMBL |
| COCAINE HYDROCHLORIDE | CHEMBL529437 | Sodium channel alpha subunit blocker | BLOCKER | ChEMBL |
1 to 10 of 84
See all 84 drugsTrials1,303
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07599800 | LIDOCAINE | PHASE2/PHASE3 | ClinicalTrials.gov | |
| NCT07592143 | LIDOCAINE | PHASE3 | ClinicalTrials.gov | |
| NCT07588750 | TOPIRAMATE | ClinicalTrials.gov | ||
| NCT07572994 | LIDOCAINE | ClinicalTrials.gov | ||
| NCT07568496 | LIDOCAINE | ClinicalTrials.gov | ||
| NCT07547371 | ARTICAINE HYDROCHLORIDE | ClinicalTrials.gov | ||
| NCT07546370 | PRILOCAINE | PHASE4 | ClinicalTrials.gov | |
| NCT07546370 | LIDOCAINE | PHASE4 | ClinicalTrials.gov | |
| NCT07536594 | LIDOCAINE | ClinicalTrials.gov | ||
| NCT07511400 | LIDOCAINE | EARLY_PHASE1 | ClinicalTrials.gov |
1 to 10 of 1,303
See all 1,303 trialsNIH grants1,300
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | SCN8A papers | Newest fiscal year |
|---|---|---|---|
| R01NS034509 | Functional Genetics of the Neuronal Sodium Channel Gene SCN8A | 54 | 2025 |
| P50HD105351 | Boston Children's Hospital/HMS Intellectual and Developmental Disabilities Research Center | 7 | 2025 |
| R01MH132226 | Probing brain circuit and behavior with protein:protein interaction modulators | 6 | 2025 |
| R01NS045594 | Study of Activity-Dependent Sympathetic Sprouting | 6 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 6 | 2025 |
| R01NS031348 | Genetic Determinants of Epilepsy in Murine Systems | 5 | 2025 |
| T32HL007853 | Multidisciplinary Cardiovascular Research Training | 5 | 2025 |
| U24NS120854 | ClinGen Expert Curation Panel for the Epilepsies | 5 | 2025 |
| UL1TR001878 | Institutional Clinical and Translational Science Award | 5 | 2025 |
| P30ES005022 | Rutgers Center for Environmental Exposure and Disease (CEED) | 4 | 2025 |
1 to 10 of 1,300Source NIH's project files
See all 1,300 nih grantsPapers2,325
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Differential effects of sodium channel blockers on SCN8A gain-of-function variants associated with drug-responsive or -resistant epilepsy. | Pharmacol Res | 2026 | 42800573 | PubTator, text mining | PubMed |
| Experimental induction of myelin damage in post-mortem human brain slice cultures. | Acta Neuropathol Commun | 2026 | 42760561 | PubTator, text mining | PubMed |
| A designer saxitoxin-engineered sodium channel pair as a general tool for subtype-selective inhibition. | Cell Chem Biol | 2026 | 42679814 | PubTator, text mining | PubMed |
| [Electroclinical recognition of SCN2A, SCN8A, KCNQ2, and KCNQ3 pathogenic variants]. | Medicina (B Aires) | 2026 | 42659555 | PubTator, text mining | PubMed |
| Antiseizure Medications in Development: Novel Mechanisms, Precision Therapy, and the Move Towards Disease Modification. | Curr Issues Mol Biol | 2026 | 42651828 | PubTator, text mining | PubMed |
| Molecular determinants of functional voltage-gated sodium (Nav) channel diversity in mammalian central neurons. | J Physiol | 2026 | 42555659 | PubTator, text mining | PubMed |
| Sodium ion channels as therapeutic targets in epilepsy: a drug discovery perspective. | Bioorg Chem | 2026 | 42508198 | PubTator, text mining | PubMed |
| Progress report on new epilepsy treatments: A summary of the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII). II. Treatments in more advanced clinical development. | Epilepsia | 2026 | 42470359 | PubTator, text mining | PubMed |
| Functional evidence for SCN8A splice-donor variant c.4419+1 A > G causing loss of function. | Hum Genome Var | 2026 | 42373593 | PubTator, text mining | PubMed |
| Differential regulation of β1-dependent voltage shifts and kinetic modulation by an extracellular glutamate in NaV1.6 VSDIV. | J Gen Physiol | 2026 | 42370886 | PubTator, text mining | PubMed |
1 to 10 of 2,325
See all 2,325 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/6334
GET https://conductscience.org/api/genes/v1/6334/patents?page=2