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Gene · 6334

SCN8A: sodium voltage-gated channel alpha subunit 8

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SCN8A: sodium voltage-gated channel alpha subunit 8. Genes, record 6334. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6334

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Gene

Symbol
SCN8A
HGNC
Name
sodium voltage-gated channel alpha subunit 8
HGNC
NCBI Gene ID
6334
NCBI Gene
HGNC ID
HGNC:10596
HGNC
Ensembl
ENSG00000196876
NCBI Gene
Aliases
BFIS5, CERIII, CIAT, CerIII, DEE13, EIEE13, MED, MYOCL2, NaCh6, Nav1.6, PN4
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9UQD0Sodium channel protein type 8 subunit alpha1,9807Ensembl, GeneID, HGNC

Source UniProt

Patents46

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1463878Q9UQD0Espacenet
EP 4641201 A22025-10-296963Q9UQD0Espacenet
JP 2025529142 A2025-09-043850Q9UQD0Espacenet
US 12371689 B22025-07-293850Q9UQD0Espacenet
JP 2025517969 A2025-06-126963Q9UQD0Espacenet
JP 2024520478 A2024-05-2433Q9UQD0Espacenet
JP 2023548973 A2023-11-21235Q9UQD0Espacenet
US 11464217 B22022-10-1126Q9UQD0Espacenet
US 11446398 B22022-09-2080256Q9UQD0Espacenet
US 11400116 B22022-08-023879Q9UQD0Espacenet

1 to 10 of 46

See all 46 patents

Drugs84

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ARTICAINECHEMBL1093Sodium channel alpha subunit blockerBLOCKERChEMBL
ARTICAINE HYDROCHLORIDECHEMBL1200819Sodium channel alpha subunit blockerBLOCKERChEMBL
BENOXINATECHEMBL1200Sodium channel alpha subunit blockerBLOCKERChEMBL
BENOXINATE HYDROCHLORIDECHEMBL1200654Sodium channel alpha subunit blockerBLOCKERChEMBL
CARBAMAZEPINECHEMBL108Sodium channel alpha subunit blockerBLOCKERChEMBL
CENOBAMATECHEMBL3989949Sodium channel alpha subunit inhibitorINHIBITORChEMBL
CHLOROPROCAINECHEMBL1179047Sodium channel alpha subunit blockerBLOCKERChEMBL
CHLOROPROCAINE HYDROCHLORIDECHEMBL944Sodium channel alpha subunit blockerBLOCKERChEMBL
COCAINECHEMBL370805Sodium channel alpha subunit blockerBLOCKERChEMBL
COCAINE HYDROCHLORIDECHEMBL529437Sodium channel alpha subunit blockerBLOCKERChEMBL

1 to 10 of 84

See all 84 drugs

Trials1,303

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants1,300

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSCN8A papersNewest fiscal year
R01NS034509Functional Genetics of the Neuronal Sodium Channel Gene SCN8A542025
P50HD105351Boston Children's Hospital/HMS Intellectual and Developmental Disabilities Research Center72025
R01MH132226Probing brain circuit and behavior with protein:protein interaction modulators62025
R01NS045594Study of Activity-Dependent Sympathetic Sprouting62025
UL1TR001863Yale Clinical and Translational Science Award62025
R01NS031348Genetic Determinants of Epilepsy in Murine Systems52025
T32HL007853Multidisciplinary Cardiovascular Research Training52025
U24NS120854ClinGen Expert Curation Panel for the Epilepsies52025
UL1TR001878Institutional Clinical and Translational Science Award52025
P30ES005022Rutgers Center for Environmental Exposure and Disease (CEED)42025

1 to 10 of 1,300Source NIH's project files

See all 1,300 nih grants

Papers2,325

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Differential effects of sodium channel blockers on SCN8A gain-of-function variants associated with drug-responsive or -resistant epilepsy.Pharmacol Res202642800573PubTator, text miningPubMed
Experimental induction of myelin damage in post-mortem human brain slice cultures.Acta Neuropathol Commun202642760561PubTator, text miningPubMed
A designer saxitoxin-engineered sodium channel pair as a general tool for subtype-selective inhibition.Cell Chem Biol202642679814PubTator, text miningPubMed
[Electroclinical recognition of SCN2A, SCN8A, KCNQ2, and KCNQ3 pathogenic variants].Medicina (B Aires)202642659555PubTator, text miningPubMed
Antiseizure Medications in Development: Novel Mechanisms, Precision Therapy, and the Move Towards Disease Modification.Curr Issues Mol Biol202642651828PubTator, text miningPubMed
Molecular determinants of functional voltage-gated sodium (Nav) channel diversity in mammalian central neurons.J Physiol202642555659PubTator, text miningPubMed
Sodium ion channels as therapeutic targets in epilepsy: a drug discovery perspective.Bioorg Chem202642508198PubTator, text miningPubMed
Progress report on new epilepsy treatments: A summary of the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII). II. Treatments in more advanced clinical development.Epilepsia202642470359PubTator, text miningPubMed
Functional evidence for SCN8A splice-donor variant c.4419+1 A > G causing loss of function.Hum Genome Var202642373593PubTator, text miningPubMed
Differential regulation of β1-dependent voltage shifts and kinetic modulation by an extracellular glutamate in NaV1.6 VSDIV.J Gen Physiol202642370886PubTator, text miningPubMed

1 to 10 of 2,325

See all 2,325 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/6334

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