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Gene · 65125

WNK1: WNK lysine deficient protein kinase 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. WNK1: WNK lysine deficient protein kinase 1. Genes, record 65125. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/65125

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Gene

Symbol
WNK1
HGNC
Name
WNK lysine deficient protein kinase 1
HGNC
NCBI Gene ID
65125
NCBI Gene
HGNC ID
HGNC:14540
HGNC
Ensembl
ENSG00000060237
NCBI Gene
Aliases
HSAN2, HSN2, KDP, PPP1R167, PRKWNK1, PSK, p65
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9H4A3Serine/threonine-protein kinase WNK12,3825Ensembl, GeneID, HGNC

Source UniProt

Patents29

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1469904Q9H4A3Espacenet
EP 4650780 A22025-11-194881Q9H4A3Espacenet
EP 4640849 A22025-10-29672Q9H4A3Espacenet
EP 4641201 A22025-10-294453Q9H4A3Espacenet
JP 2025147176 A2025-10-0614274Q9H4A3Espacenet
JP 2025529142 A2025-09-048078Q9H4A3Espacenet
US 12371689 B22025-07-298078Q9H4A3Espacenet
JP 2025519096 A2025-06-24672Q9H4A3Espacenet
JP 2025517969 A2025-06-124453Q9H4A3Espacenet
JP 2025517970 A2025-06-124881Q9H4A3Espacenet

1 to 10 of 29

See all 29 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,306

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleWNK1 papersNewest fiscal year
R01DK051496WNK Kinase Regulation of Thiazide-sensitive NaCl Transport252025
R01DK110358Regulation of WNK signaling by potassium and Mo25: structure, function and physiology122025
P30CA142543UT Southwestern Medical Center Simmons Comprehensive Cancer Center112025
R01DK098145Control of the Renal WNK Signaling Pathway by Phase Transitions102025
R01DK111542WNK kinase cascade in health and disease92025
P30CA008748Cancer Center Support Grant72025
R01DK093501WNK-SPAK signaling in the Distal Nephron72025
P30DA018343Yale/NIDA Neuroproteomics Center52025
R01DK098141Regulation of renal ion transport by the CUL3-WNK-SPAK pathway52025
ZIADE000735Ca2+ signaling and HCO3- secretion by exocrine glands52025

1 to 10 of 1,306Source NIH's project files

See all 1,306 nih grants

Papers2,081

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
WNK1 Phosphorylation Sites in TBC1D1 and TBC1D4 Modulate Cell-Surface Abundance of GLUT1.Cells202642738876PubTator, text miningPubMed
[225Ac]Ac-iPSMA Radiopharmaceuticals for Targeted Alpha Therapy: Design, Synthesis, and Preclinical Evaluation.Int J Mol Sci202642737682PubTator, text miningPubMed
WNK1: an atypical kinase vulnerability in T-ALL.Blood202642720175PubTator, text miningPubMed
Hypotonicity-Induced WNK1 Phosphorylation Prevents H2O2-Induced Apoptosis in Vascular Smooth Muscle Cells.Basic Clin Pharmacol Toxicol202642675813PubTator, text miningPubMed
WNK-dependent phosphorylation of gephyrin tunes GABAA receptors at inhibitory synapses and modulates anxiety behavior.Proc Natl Acad Sci U S A202642640800PubTator, text miningPubMed
With no lysine kinase 1 in hepatic stellate cells promotes mouse and human liver fibrosis through glycolytic triosephosphate isomerase 1.Hepatology202642560363PubTator, text miningPubMed
miR-337-5p Targets WNK1 to Promote IL-13-Induced Nasal Epithelial Inflammation in Allergic Rhinitis.Int Arch Allergy Immunol202642545909PubTator, text miningPubMed
Genetic Variants in the MTHFR and WNK1 Genes and Their Contribution to Hypertension Susceptibility.Int J Med Sci202642524532PubTator, text miningPubMed
WNK1 is a central osmolality sensor that regulates arginine vasopressin secretion.Curr Opin Nephrol Hypertens202642471779PubTator, text miningPubMed
Discoidin domain receptor 1 contributes to colorectal cancer progression by promoting cell migration and invasion.Life Sci202642462480PubTator, text miningPubMed

1 to 10 of 2,081

See all 2,081 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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