Gene · 65125
WNK1: WNK lysine deficient protein kinase 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. WNK1: WNK lysine deficient protein kinase 1. Genes, record 65125. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/65125
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9H4A3 | Serine/threonine-protein kinase WNK1 | 2,382 | 5 | Ensembl, GeneID, HGNC |
Source UniProt
Patents29
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 69904 | Q9H4A3 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 4881 | Q9H4A3 | Espacenet |
| EP 4640849 A2 | 2025-10-29 | 672 | Q9H4A3 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 4453 | Q9H4A3 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 14274 | Q9H4A3 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 8078 | Q9H4A3 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 8078 | Q9H4A3 | Espacenet |
| JP 2025519096 A | 2025-06-24 | 672 | Q9H4A3 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 4453 | Q9H4A3 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 4881 | Q9H4A3 | Espacenet |
1 to 10 of 29
See all 29 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,306
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | WNK1 papers | Newest fiscal year |
|---|---|---|---|
| R01DK051496 | WNK Kinase Regulation of Thiazide-sensitive NaCl Transport | 25 | 2025 |
| R01DK110358 | Regulation of WNK signaling by potassium and Mo25: structure, function and physiology | 12 | 2025 |
| P30CA142543 | UT Southwestern Medical Center Simmons Comprehensive Cancer Center | 11 | 2025 |
| R01DK098145 | Control of the Renal WNK Signaling Pathway by Phase Transitions | 10 | 2025 |
| R01DK111542 | WNK kinase cascade in health and disease | 9 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 7 | 2025 |
| R01DK093501 | WNK-SPAK signaling in the Distal Nephron | 7 | 2025 |
| P30DA018343 | Yale/NIDA Neuroproteomics Center | 5 | 2025 |
| R01DK098141 | Regulation of renal ion transport by the CUL3-WNK-SPAK pathway | 5 | 2025 |
| ZIADE000735 | Ca2+ signaling and HCO3- secretion by exocrine glands | 5 | 2025 |
1 to 10 of 1,306Source NIH's project files
See all 1,306 nih grantsPapers2,081
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| WNK1 Phosphorylation Sites in TBC1D1 and TBC1D4 Modulate Cell-Surface Abundance of GLUT1. | Cells | 2026 | 42738876 | PubTator, text mining | PubMed |
| [225Ac]Ac-iPSMA Radiopharmaceuticals for Targeted Alpha Therapy: Design, Synthesis, and Preclinical Evaluation. | Int J Mol Sci | 2026 | 42737682 | PubTator, text mining | PubMed |
| WNK1: an atypical kinase vulnerability in T-ALL. | Blood | 2026 | 42720175 | PubTator, text mining | PubMed |
| Hypotonicity-Induced WNK1 Phosphorylation Prevents H2O2-Induced Apoptosis in Vascular Smooth Muscle Cells. | Basic Clin Pharmacol Toxicol | 2026 | 42675813 | PubTator, text mining | PubMed |
| WNK-dependent phosphorylation of gephyrin tunes GABAA receptors at inhibitory synapses and modulates anxiety behavior. | Proc Natl Acad Sci U S A | 2026 | 42640800 | PubTator, text mining | PubMed |
| With no lysine kinase 1 in hepatic stellate cells promotes mouse and human liver fibrosis through glycolytic triosephosphate isomerase 1. | Hepatology | 2026 | 42560363 | PubTator, text mining | PubMed |
| miR-337-5p Targets WNK1 to Promote IL-13-Induced Nasal Epithelial Inflammation in Allergic Rhinitis. | Int Arch Allergy Immunol | 2026 | 42545909 | PubTator, text mining | PubMed |
| Genetic Variants in the MTHFR and WNK1 Genes and Their Contribution to Hypertension Susceptibility. | Int J Med Sci | 2026 | 42524532 | PubTator, text mining | PubMed |
| WNK1 is a central osmolality sensor that regulates arginine vasopressin secretion. | Curr Opin Nephrol Hypertens | 2026 | 42471779 | PubTator, text mining | PubMed |
| Discoidin domain receptor 1 contributes to colorectal cancer progression by promoting cell migration and invasion. | Life Sci | 2026 | 42462480 | PubTator, text mining | PubMed |
1 to 10 of 2,081
See all 2,081 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/65125
GET https://conductscience.org/api/genes/v1/65125/patents?page=2