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Gene · 6529

SLC6A1: solute carrier family 6 member 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SLC6A1: solute carrier family 6 member 1. Genes, record 6529. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6529

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Gene

Symbol
SLC6A1
HGNC
Name
solute carrier family 6 member 1
HGNC
NCBI Gene ID
6529
NCBI Gene
HGNC ID
HGNC:11042
HGNC
Ensembl
ENSG00000157103
NCBI Gene
Aliases
GABATHG, GABATR, GAT-1, GAT1, MAE, hGAT-1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P30531Sodium- and chloride-dependent GABA transporter 15995Ensembl, GeneID, HGNC

Source UniProt

Patents73

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1464767P30531Espacenet
EP 4650780 A22025-11-193339P30531Espacenet
WO 2025228976 A12025-11-061P30531Espacenet
EP 4641201 A22025-10-292907P30531Espacenet
JP 2025529142 A2025-09-044277P30531Espacenet
US 12371689 B22025-07-294277P30531Espacenet
JP 2025517969 A2025-06-122907P30531Espacenet
JP 2025517970 A2025-06-123339P30531Espacenet
US 12156890 B22024-12-035P30531Espacenet
EP 4429715 A12024-09-182P30531Espacenet

1 to 10 of 73

See all 73 patents

Drugs2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
TIAGABINECHEMBL1027GABA transporter 1 inhibitorINHIBITORChEMBL
TIAGABINE HYDROCHLORIDECHEMBL1695GABA transporter 1 inhibitorINHIBITORChEMBL

Trials12

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT02387710TIAGABINEPHASE22017-06-06ClinicalTrials.gov
NCT01587339TIAGABINEClinicalTrials.gov
NCT00236067TIAGABINE HYDROCHLORIDEPHASE3ClinicalTrials.gov
NCT00236054TIAGABINE HYDROCHLORIDEPHASE3ClinicalTrials.gov
NCT00236015TIAGABINE HYDROCHLORIDEPHASE3ClinicalTrials.gov
NCT00233675TIAGABINEPHASE3ClinicalTrials.gov
NCT00218166TIAGABINEPHASE2ClinicalTrials.gov
NCT00214994TIAGABINE HYDROCHLORIDEPHASE3ClinicalTrials.gov
NCT00179465TIAGABINEPHASE3ClinicalTrials.gov
NCT00129298TIAGABINEPHASE2ClinicalTrials.gov

1 to 10 of 12

See all 12 trials

NIH grants1,412

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSLC6A1 papersNewest fiscal year
P50HD103537Overall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at Vanderbilt62025
U24NS120854ClinGen Expert Curation Panel for the Epilepsies52025
R01DA036596Regulation of Neuronal GPCR Signaling42025
U01NS114312Multi-Site Validation of Biomarkers and Core Clinical Outcome Measures for Clinical Trials Readiness in CDKL5 Deficiency Disorder42025
UL1TR001863Yale Clinical and Translational Science Award42025
P30CA008748Cancer Center Support Grant32025
R01MH094681Cortical and subcortical chandelier cell pathophysiology and symptomatology in autism32025
R01MH101221Rare Mutations and Autism Spectrum Disorders32025
R01MH123184Methods for single-cell CRISPR screens and multiomic data: constructing powerful well-calibrated tests, circumventing unmeasured confounding, and accounting for denoising and imputation32025
R01NS121718Promoting Protein Trafficking with 4-phenylbutyrate to Treat Genetic Epilepsy32025

1 to 10 of 1,412Source NIH's project files

See all 1,412 nih grants

Papers1,693

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Glycerol Phenylbutyrate Treatment in a Pediatric Cohort of SLC6A1-Related Neurodevelopmental Disorder.Pediatr Neurol202642767125PubTator, text miningPubMed
Epilepsy with myoclonic-atonic seizures: a comprehensive review with emphasis on current and emerging pharmacotherapies.Expert Rev Neurother202642762175PubTator, text miningPubMed
Drug repurposing of glycerol phenylbutyrate for children with SLC6A1-related neurodevelopmental disorder: A prospective open-label case series.Mol Genet Metab202642735473PubTator, text miningPubMed
Phenylbutyrate-Responsive SLC6A1-Related Neurodevelopmental Disorder Associated With a Familial Variant.J Child Neurol202642731082PubTator, text miningPubMed
4-Phenylbutyrate Plus Wildtype GAT-1 Augmentation: A Dual Therapy to Rescue SLC6A1 Variant-Associated Developmental and Epileptic Encephalopathy.Genes (Basel)202642650175PubTator, text miningPubMed
Multi-glial inhibitory plasticity in epilepsy and sleep: implications for post-traumatic epileptogenesis.Exp Neurol202642617910PubTator, text miningPubMed
Mapping Trofinetide Polypharmacology in Rett Syndrome: A Multi-Stage Computational Analysis.J Comput Chem202642530159PubTator, text miningPubMed
SCAP-derived exosomes restore excitatory-inhibitory balance and attenuate glutamate-induced excitotoxicity via modulation of GABAergic signaling.Neuroscience202642520916PubTator, text miningPubMed
In Silico Selection of GAT-1 Inhibitors.Pharmaceuticals (Basel)202642515695PubTator, text miningPubMed
Environmental and treatment-related factors associated with developmental outcomes in genetic epilepsies.Epilepsia202642470662PubTator, text miningPubMed

1 to 10 of 1,693

See all 1,693 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/6529

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