Gene · 6529
SLC6A1: solute carrier family 6 member 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. SLC6A1: solute carrier family 6 member 1. Genes, record 6529. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6529
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P30531 | Sodium- and chloride-dependent GABA transporter 1 | 599 | 5 | Ensembl, GeneID, HGNC |
Source UniProt
Patents73
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 64767 | P30531 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 3339 | P30531 | Espacenet |
| WO 2025228976 A1 | 2025-11-06 | 1 | P30531 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 2907 | P30531 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 4277 | P30531 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 4277 | P30531 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 2907 | P30531 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 3339 | P30531 | Espacenet |
| US 12156890 B2 | 2024-12-03 | 5 | P30531 | Espacenet |
| EP 4429715 A1 | 2024-09-18 | 2 | P30531 | Espacenet |
1 to 10 of 73
See all 73 patentsDrugs2
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
Trials12
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT02387710 | TIAGABINE | PHASE2 | 2017-06-06 | ClinicalTrials.gov |
| NCT01587339 | TIAGABINE | ClinicalTrials.gov | ||
| NCT00236067 | TIAGABINE HYDROCHLORIDE | PHASE3 | ClinicalTrials.gov | |
| NCT00236054 | TIAGABINE HYDROCHLORIDE | PHASE3 | ClinicalTrials.gov | |
| NCT00236015 | TIAGABINE HYDROCHLORIDE | PHASE3 | ClinicalTrials.gov | |
| NCT00233675 | TIAGABINE | PHASE3 | ClinicalTrials.gov | |
| NCT00218166 | TIAGABINE | PHASE2 | ClinicalTrials.gov | |
| NCT00214994 | TIAGABINE HYDROCHLORIDE | PHASE3 | ClinicalTrials.gov | |
| NCT00179465 | TIAGABINE | PHASE3 | ClinicalTrials.gov | |
| NCT00129298 | TIAGABINE | PHASE2 | ClinicalTrials.gov |
1 to 10 of 12
See all 12 trialsNIH grants1,412
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | SLC6A1 papers | Newest fiscal year |
|---|---|---|---|
| P50HD103537 | Overall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at Vanderbilt | 6 | 2025 |
| U24NS120854 | ClinGen Expert Curation Panel for the Epilepsies | 5 | 2025 |
| R01DA036596 | Regulation of Neuronal GPCR Signaling | 4 | 2025 |
| U01NS114312 | Multi-Site Validation of Biomarkers and Core Clinical Outcome Measures for Clinical Trials Readiness in CDKL5 Deficiency Disorder | 4 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 4 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 3 | 2025 |
| R01MH094681 | Cortical and subcortical chandelier cell pathophysiology and symptomatology in autism | 3 | 2025 |
| R01MH101221 | Rare Mutations and Autism Spectrum Disorders | 3 | 2025 |
| R01MH123184 | Methods for single-cell CRISPR screens and multiomic data: constructing powerful well-calibrated tests, circumventing unmeasured confounding, and accounting for denoising and imputation | 3 | 2025 |
| R01NS121718 | Promoting Protein Trafficking with 4-phenylbutyrate to Treat Genetic Epilepsy | 3 | 2025 |
1 to 10 of 1,412Source NIH's project files
See all 1,412 nih grantsPapers1,693
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Glycerol Phenylbutyrate Treatment in a Pediatric Cohort of SLC6A1-Related Neurodevelopmental Disorder. | Pediatr Neurol | 2026 | 42767125 | PubTator, text mining | PubMed |
| Epilepsy with myoclonic-atonic seizures: a comprehensive review with emphasis on current and emerging pharmacotherapies. | Expert Rev Neurother | 2026 | 42762175 | PubTator, text mining | PubMed |
| Drug repurposing of glycerol phenylbutyrate for children with SLC6A1-related neurodevelopmental disorder: A prospective open-label case series. | Mol Genet Metab | 2026 | 42735473 | PubTator, text mining | PubMed |
| Phenylbutyrate-Responsive SLC6A1-Related Neurodevelopmental Disorder Associated With a Familial Variant. | J Child Neurol | 2026 | 42731082 | PubTator, text mining | PubMed |
| 4-Phenylbutyrate Plus Wildtype GAT-1 Augmentation: A Dual Therapy to Rescue SLC6A1 Variant-Associated Developmental and Epileptic Encephalopathy. | Genes (Basel) | 2026 | 42650175 | PubTator, text mining | PubMed |
| Multi-glial inhibitory plasticity in epilepsy and sleep: implications for post-traumatic epileptogenesis. | Exp Neurol | 2026 | 42617910 | PubTator, text mining | PubMed |
| Mapping Trofinetide Polypharmacology in Rett Syndrome: A Multi-Stage Computational Analysis. | J Comput Chem | 2026 | 42530159 | PubTator, text mining | PubMed |
| SCAP-derived exosomes restore excitatory-inhibitory balance and attenuate glutamate-induced excitotoxicity via modulation of GABAergic signaling. | Neuroscience | 2026 | 42520916 | PubTator, text mining | PubMed |
| In Silico Selection of GAT-1 Inhibitors. | Pharmaceuticals (Basel) | 2026 | 42515695 | PubTator, text mining | PubMed |
| Environmental and treatment-related factors associated with developmental outcomes in genetic epilepsies. | Epilepsia | 2026 | 42470662 | PubTator, text mining | PubMed |
1 to 10 of 1,693
See all 1,693 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/6529
GET https://conductscience.org/api/genes/v1/6529/patents?page=2