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Gene · 6716

SRD5A2: steroid 5 alpha-reductase 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SRD5A2: steroid 5 alpha-reductase 2. Genes, record 6716. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6716

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Gene

Symbol
SRD5A2
HGNC
Name
steroid 5 alpha-reductase 2
HGNC
NCBI Gene ID
6716
NCBI Gene
HGNC ID
HGNC:11285
HGNC
Ensembl
ENSG00000277893
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P312133-oxo-5-alpha-steroid 4-dehydrogenase 22541Ensembl, GeneID, HGNC

Source UniProt

Patents11

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4640849 A22025-10-293651P31213Espacenet
EP 4641201 A22025-10-2922662P31213Espacenet
JP 2025519096 A2025-06-243651P31213Espacenet
JP 2025517969 A2025-06-1222662P31213Espacenet
US 11446398 B22022-09-2084442P31213Espacenet
US 11400116 B22022-08-02103P31213Espacenet
JP 2022524081 A2022-04-27187413P31213Espacenet
JP 2018527883 A2018-09-27176P31213Espacenet
US 8586006 B22013-11-1956301P31213Espacenet
JP 2010500568 A2010-01-0763559P31213Espacenet

1 to 10 of 11

See all 11 patents

Drugs3

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ABIRATERONECHEMBL254328Steroid 5-alpha-reductase inhibitorINHIBITORChEMBL
DUTASTERIDECHEMBL1200969Steroid 5-alpha-reductase inhibitorINHIBITORChEMBL
FINASTERIDECHEMBL710Steroid 5-alpha-reductase 2 inhibitorINHIBITORChEMBL

Trials192

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07570979ABIRATERONEPHASE1ClinicalTrials.gov
NCT07553988ABIRATERONEPHASE2ClinicalTrials.gov
NCT07435012FINASTERIDEPHASE3ClinicalTrials.gov
NCT07421804DUTASTERIDEClinicalTrials.gov
NCT07417449DUTASTERIDEClinicalTrials.gov
NCT07299292ABIRATERONEPHASE2ClinicalTrials.gov
NCT07237269ABIRATERONEPHASE2ClinicalTrials.gov
NCT07226986ABIRATERONEPHASE1/PHASE2ClinicalTrials.gov
NCT07190300ABIRATERONEPHASE1/PHASE2ClinicalTrials.gov
NCT07154914ABIRATERONEClinicalTrials.gov

1 to 10 of 192

See all 192 trials

NIH grants776

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSRD5A2 papersNewest fiscal year
P30ES013508Center of Excellence in Environmental Toxicology162025
P50CA097186The Pacific Northwest Prostate Cancer SPORE162025
P30CA016056Roswell Park Cancer Center Support Grant122025
P01CA163227Androgen Receptor Action in Castration Resistant Prostate Cancer102025
P30CA015704Cancer Center Support Grant72025
R01CA172382Elucidating a novel molecular biomarker for castration-resistant prostate cancer72025
P30CA014089University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)62025
P30CA016672Cancer Center Support Grant62025
P30CA054174Mays Cancer Center at UT Health SA62025
R01GM086596Activation of androgen biosynthesis and drug metabolism by cytochrome b562025

1 to 10 of 776Source NIH's project files

See all 776 nih grants

Papers1,787

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Inherited Predisposition in Steroidogenic Pathways and Risk of Transition to Incurable Prostate Cancer in Men With Localized Disease.J Urol202642821636PubTator, text miningPubMed
Integrative Genetic and Bioinformatic Analysis of Androgen Pathway Gene Polymorphisms, Testosterone, and PSA Levels in Prostate Cancer.Genet Test Mol Biomarkers202642765541PubTator, text miningPubMed
Mixed-Culture Fermentation of Coffee Pulp Induces Metabolomic Changes and Enhances Multi-Target Bioactivity Relevant to Androgenetic Alopecia.Int J Mol Sci202642737762PubTator, text miningPubMed
Molecular analysis of individuals with suspected 46,XY differences of sex development in a homogenous and understudied population.Hum Mol Genet202642725913PubTator, text miningPubMed
Bioinformatic Identification and Experimental Validation of a Prognostic Transcriptional Signature Derived from Asparagine Metabolism-Related Genes in Breast Cancer.Biology (Basel)202642651744PubTator, text miningPubMed
Hair Growth-Supporting and Follicle-Protective Potential of a Botanical-Based Supplement Ingredient: In Vitro, Ex Vivo, and Molecular Docking Studies.Biomolecules202642650873PubTator, text miningPubMed
Clinical, hormonal, and genetic spectrum of cryptorchidism: a comprehensive evaluation of patients referred for pediatric endocrinological assessment.J Pediatr Endocrinol Metab202642638530PubTator, text miningPubMed
Clinical and molecular characterization of 5α-reductase deficiency type 2 in 13 patients: First report of a family with homozygous deletion in exon 1 of SRD5A2.Arch Pediatr202642636744PubTator, text miningPubMed
High SRD5A2 expression is associated with poor prognosis and promotes tumor cell progression in colorectal cancer.Transl Cancer Res202642591618PubTator, text miningPubMed
Male predominance and pubertal resolution in vernal Keratoconjunctivitis: Exploring associations with ocular surface sex steroid intracrinology.Ocul Surf202642575429PubTator, text miningPubMed

1 to 10 of 1,787

See all 1,787 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/6716

GET https://conductscience.org/api/genes/v1/6716/patents