Gene · 6716
SRD5A2: steroid 5 alpha-reductase 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. SRD5A2: steroid 5 alpha-reductase 2. Genes, record 6716. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6716
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P31213 | 3-oxo-5-alpha-steroid 4-dehydrogenase 2 | 254 | 1 | Ensembl, GeneID, HGNC |
Source UniProt
Patents11
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4640849 A2 | 2025-10-29 | 3651 | P31213 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 22662 | P31213 | Espacenet |
| JP 2025519096 A | 2025-06-24 | 3651 | P31213 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 22662 | P31213 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 84442 | P31213 | Espacenet |
| US 11400116 B2 | 2022-08-02 | 103 | P31213 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 187413 | P31213 | Espacenet |
| JP 2018527883 A | 2018-09-27 | 176 | P31213 | Espacenet |
| US 8586006 B2 | 2013-11-19 | 56301 | P31213 | Espacenet |
| JP 2010500568 A | 2010-01-07 | 63559 | P31213 | Espacenet |
1 to 10 of 11
See all 11 patentsDrugs3
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
Trials192
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07570979 | ABIRATERONE | PHASE1 | ClinicalTrials.gov | |
| NCT07553988 | ABIRATERONE | PHASE2 | ClinicalTrials.gov | |
| NCT07435012 | FINASTERIDE | PHASE3 | ClinicalTrials.gov | |
| NCT07421804 | DUTASTERIDE | ClinicalTrials.gov | ||
| NCT07417449 | DUTASTERIDE | ClinicalTrials.gov | ||
| NCT07299292 | ABIRATERONE | PHASE2 | ClinicalTrials.gov | |
| NCT07237269 | ABIRATERONE | PHASE2 | ClinicalTrials.gov | |
| NCT07226986 | ABIRATERONE | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT07190300 | ABIRATERONE | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT07154914 | ABIRATERONE | ClinicalTrials.gov |
1 to 10 of 192
See all 192 trialsNIH grants776
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | SRD5A2 papers | Newest fiscal year |
|---|---|---|---|
| P30ES013508 | Center of Excellence in Environmental Toxicology | 16 | 2025 |
| P50CA097186 | The Pacific Northwest Prostate Cancer SPORE | 16 | 2025 |
| P30CA016056 | Roswell Park Cancer Center Support Grant | 12 | 2025 |
| P01CA163227 | Androgen Receptor Action in Castration Resistant Prostate Cancer | 10 | 2025 |
| P30CA015704 | Cancer Center Support Grant | 7 | 2025 |
| R01CA172382 | Elucidating a novel molecular biomarker for castration-resistant prostate cancer | 7 | 2025 |
| P30CA014089 | University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG) | 6 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 6 | 2025 |
| P30CA054174 | Mays Cancer Center at UT Health SA | 6 | 2025 |
| R01GM086596 | Activation of androgen biosynthesis and drug metabolism by cytochrome b5 | 6 | 2025 |
1 to 10 of 776Source NIH's project files
See all 776 nih grantsPapers1,787
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Inherited Predisposition in Steroidogenic Pathways and Risk of Transition to Incurable Prostate Cancer in Men With Localized Disease. | J Urol | 2026 | 42821636 | PubTator, text mining | PubMed |
| Integrative Genetic and Bioinformatic Analysis of Androgen Pathway Gene Polymorphisms, Testosterone, and PSA Levels in Prostate Cancer. | Genet Test Mol Biomarkers | 2026 | 42765541 | PubTator, text mining | PubMed |
| Mixed-Culture Fermentation of Coffee Pulp Induces Metabolomic Changes and Enhances Multi-Target Bioactivity Relevant to Androgenetic Alopecia. | Int J Mol Sci | 2026 | 42737762 | PubTator, text mining | PubMed |
| Molecular analysis of individuals with suspected 46,XY differences of sex development in a homogenous and understudied population. | Hum Mol Genet | 2026 | 42725913 | PubTator, text mining | PubMed |
| Bioinformatic Identification and Experimental Validation of a Prognostic Transcriptional Signature Derived from Asparagine Metabolism-Related Genes in Breast Cancer. | Biology (Basel) | 2026 | 42651744 | PubTator, text mining | PubMed |
| Hair Growth-Supporting and Follicle-Protective Potential of a Botanical-Based Supplement Ingredient: In Vitro, Ex Vivo, and Molecular Docking Studies. | Biomolecules | 2026 | 42650873 | PubTator, text mining | PubMed |
| Clinical, hormonal, and genetic spectrum of cryptorchidism: a comprehensive evaluation of patients referred for pediatric endocrinological assessment. | J Pediatr Endocrinol Metab | 2026 | 42638530 | PubTator, text mining | PubMed |
| Clinical and molecular characterization of 5α-reductase deficiency type 2 in 13 patients: First report of a family with homozygous deletion in exon 1 of SRD5A2. | Arch Pediatr | 2026 | 42636744 | PubTator, text mining | PubMed |
| High SRD5A2 expression is associated with poor prognosis and promotes tumor cell progression in colorectal cancer. | Transl Cancer Res | 2026 | 42591618 | PubTator, text mining | PubMed |
| Male predominance and pubertal resolution in vernal Keratoconjunctivitis: Exploring associations with ocular surface sex steroid intracrinology. | Ocul Surf | 2026 | 42575429 | PubTator, text mining | PubMed |
1 to 10 of 1,787
See all 1,787 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/6716
GET https://conductscience.org/api/genes/v1/6716/patents