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Gene · 6870

TACR3: tachykinin receptor 3

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TACR3: tachykinin receptor 3. Genes, record 6870. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6870

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Gene

Symbol
TACR3
HGNC
Name
tachykinin receptor 3
HGNC
NCBI Gene ID
6870
NCBI Gene
HGNC ID
HGNC:11528
HGNC
Ensembl
ENSG00000169836
NCBI Gene
Aliases
HH11, NK-3R, NK3, NK3R, NKR, TAC3R, TAC3RL
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P29371Neuromedin-K receptor4653Ensembl, GeneID, HGNC

Source UniProt

Patents31

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1466345P29371Espacenet
EP 4641201 A22025-10-293762P29371Espacenet
JP 2025529142 A2025-09-044572P29371Espacenet
US 12371689 B22025-07-294572P29371Espacenet
JP 2025517969 A2025-06-123762P29371Espacenet
US 11446398 B22022-09-2086508P29371Espacenet
US 11400116 B22022-08-02940P29371Espacenet
JP 2022524081 A2022-04-27189479P29371Espacenet
US 11078247 B22021-08-0311271P29371Espacenet
US 10772934 B22020-09-151099P29371Espacenet

1 to 10 of 31

See all 31 patents

Drugs4

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ELINZANETANTCHEMBL4802157Neurokinin 3 receptor antagonistANTAGONISTChEMBL
FEZOLINETANTCHEMBL3608680Neurokinin 3 receptor antagonistANTAGONISTChEMBL
PAVINETANTCHEMBL3545233Neurokinin 3 receptor antagonistANTAGONISTChEMBL
TALNETANTCHEMBL10188Neurokinin 3 receptor antagonistANTAGONISTChEMBL

Trials25

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07606664FEZOLINETANTPHASE3ClinicalTrials.gov
NCT07455812FEZOLINETANTClinicalTrials.gov
NCT07077395ELINZANETANTPHASE2ClinicalTrials.gov
NCT06972875FEZOLINETANTPHASE2ClinicalTrials.gov
NCT06957691FEZOLINETANTPHASE2ClinicalTrials.gov
NCT06440967FEZOLINETANTPHASE3ClinicalTrials.gov
NCT06206421FEZOLINETANTPHASE3ClinicalTrials.gov
NCT06206408FEZOLINETANTPHASE3ClinicalTrials.gov
NCT06112756ELINZANETANTPHASE22025-11-10ClinicalTrials.gov
NCT06049797FEZOLINETANTClinicalTrials.gov

1 to 10 of 25

See all 25 trials

NIH grants780

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTACR3 papersNewest fiscal year
R01HD082314Deciphering the functional role of MKRN3 in puberty and reproduction92025
P51OD011092Support for National Primate Research Center62025
P51OD011106Wisconsin National Primate Research Center Support52025
R37HD043341Towards Curative Therapies for Hypogonadotropic Diseases52025
U10AA008401Collaborative Study on the Genetics of Alcoholism (COGA).52025
T32DK007529Training Grant in Academic Endocrinology42025
P50HD104224The Massachusetts General Hospital Harvard Center for Reproductive Medicine32025
R37HD019938Reproductive physiology of gonadotropin synthesis32025
P30DK063491Diabetes Research Center (DRC)22025
P30DK116074Stanford Diabetes Research Center22025

1 to 10 of 780Source NIH's project files

See all 780 nih grants

Papers1,207

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Genetic landscape of a neonatal hypogonadotropic hypogonadism series: Novel variants and phenotypic spectrum.J Neuroendocrinol202642786427PubTator, text miningPubMed
Substance P and PACAP activate dural mast cells through MRGPRX2, not NK1R or PAC1/VPAC receptors.Cephalalgia202642627518PubTator, text miningPubMed
Real-world safety signals of fezolinetant in women with menopausal vasomotor symptoms: a pharmacovigilance analysis of the WHO VigiAccess database.Menopause202642610452PubTator, text miningPubMed
Real-world safety profile of fezolinetant: a disproportionality analysis based on the FAERS database.Naunyn Schmiedebergs Arch Pharmacol202642547587PubTator, text miningPubMed
Precocious puberty in boys: current insights into etiology, genetic advances, and environmental factors.Front Endocrinol (Lausanne)202642534783PubTator, text miningPubMed
Identification of a Novel Splice-Site variant in TACR3 (c.888 + 1G > A) Associated with Asthenozoospermia and Hypogonadotropic Hypogonadism in an Iranian Family.Reprod Sci202642521916PubTator, text miningPubMed
Podcast: Patient voices and clinical advances-Elinzanetant for menopause symptom management associated with breast cancer treatment in the OASIS-4 trial.Womens Health (Lond)202642515941PubTator, text miningPubMed
Neurokinin 3 Receptor Antagonists for Menopause Symptom Management.Obstet Gynecol Clin North Am202642508870PubTator, text miningPubMed
TACR3 variant confers resilience to aging and Alzheimer's disease.medRxiv202642326829PubTator, text miningPubMed
Neurokinin pathway antagonists for vasomotor symptoms in women with breast cancer: focus on elinzanetant and fezolinetant.Breast202642160911PubTator, text miningPubMed

1 to 10 of 1,207

See all 1,207 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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