Gene · 7134
TNNC1: troponin C1, slow skeletal and cardiac type
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. TNNC1: troponin C1, slow skeletal and cardiac type. Genes, record 7134. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7134
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P63316 | Troponin C, slow skeletal and cardiac muscles | 161 | 61 | Ensembl, GeneID, HGNC |
Source UniProt
Patents32
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 68343 | P63316 | Espacenet |
| JP 2025022885 A | 2025-02-14 | 4 | P63316 | Espacenet |
| JP 2025013795 A | 2025-01-28 | 7 | P63316 | Espacenet |
| JP 2024545507 A | 2024-12-09 | 1 | P63316 | Espacenet |
| KR 1020240160200 A | 2024-11-08 | 3 | P63316 | Espacenet |
| EP 4444893 A1 | 2024-10-16 | 1 | P63316 | Espacenet |
| US 11965885 B2 | 2024-04-23 | 31 | P63316 | Espacenet |
| JP 2023123507 A | 2023-09-05 | 241 | P63316 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 93030 | P63316 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 196001 | P63316 | Espacenet |
1 to 10 of 32
See all 32 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| LEVOSIMENDAN | CHEMBL2051955 | Troponin, cardiac muscle positive modulator | POSITIVE MODULATOR |
Source ChEMBL
Trials41
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07436689 | LEVOSIMENDAN | PHASE3 | ClinicalTrials.gov | |
| NCT07288398 | LEVOSIMENDAN | PHASE3 | ClinicalTrials.gov | |
| NCT07186062 | LEVOSIMENDAN | ClinicalTrials.gov | ||
| NCT06478667 | LEVOSIMENDAN | PHASE3 | ClinicalTrials.gov | |
| NCT06021587 | LEVOSIMENDAN | ClinicalTrials.gov | ||
| NCT05983250 | LEVOSIMENDAN | PHASE3 | ClinicalTrials.gov | |
| NCT05768230 | LEVOSIMENDAN | PHASE2/PHASE3 | ClinicalTrials.gov | |
| NCT05730907 | LEVOSIMENDAN | ClinicalTrials.gov | ||
| NCT04728932 | LEVOSIMENDAN | PHASE3 | ClinicalTrials.gov | |
| NCT04718350 | LEVOSIMENDAN | ClinicalTrials.gov |
1 to 10 of 41
See all 41 trialsNIH grants840
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | TNNC1 papers | Newest fiscal year |
|---|---|---|---|
| R01HL075619 | Integrative Approach to Divergent Remodeling in Thin Filament Cardiomyopathies | 6 | 2025 |
| U24HG009650 | The Clinical Genome Resource – Advancing genomic medicine through biocuration and expert assessment of genes and variants at scale | 5 | 2025 |
| P30DK020572 | Michigan Diabetes Research Center (MDRC) | 3 | 2025 |
| R01HL113006 | Human Induced Pluripotent Stem Cells for Cardiovascular Disease Modeling | 3 | 2025 |
| R01HL132401 | Mechanisms and Therapeutic Targeting of DNA Damage in Dilated Cardiomyopathy Caused by LMNA Mutations | 3 | 2025 |
| R01HL081753 | Genetic Studies of Sarcomere-based Cardiac Diseases | 2 | 2025 |
| R01HL105826 | Fast myosin binding protein-C and cardiac contractility in heart failure | 2 | 2025 |
| R01HL128368 | Engineered Stem Cells for Cardiac Repair | 2 | 2025 |
| R01HL130020 | Elucidating Mechanism of Cardiac Fibrosis with Cell Village of Pooled Human iPSCs | 2 | 2025 |
| R01HL132874 | Myofilaments as regulators of heart function in disease | 2 | 2025 |
1 to 10 of 840Source NIH's project files
See all 840 nih grantsPapers1,417
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Clinical Characteristics and Outcomes of Hypertrophic Cardiomyopathy Associated With Thin Filament Variants: Insights From the SHaRe Registry. | Circ Genom Precis Med | 2026 | 42779549 | PubTator, text mining | PubMed |
| Myosin-binding protein C N-terminal domains slow Ca2+ dissociation from cardiac thin filaments. | J Biol Chem | 2026 | 42778103 | PubTator, text mining | PubMed |
| Aberrant myocardial calcium cycling: pathogenic mechanisms and targeted therapeutics for heart failure. | Front Cardiovasc Med | 2026 | 42769728 | PubTator, text mining | PubMed |
| Construction and validation of a nomogram for the diagnosis of postmenopausal osteoporosis. | Mol Med Rep | 2026 | 42596822 | PubTator, text mining | PubMed |
| Evolutionary and physics-guided modulation of Ca 2 + sensitivity in Cardiac troponin C. | J Mol Model | 2026 | 42484751 | PubTator, text mining | PubMed |
| Contractility Drives Cardiomyocyte Maturation and the Response to Nanopatterns. | Circ Res | 2026 | 42422954 | PubTator, text mining | PubMed |
| The Cardiac Sarcomere: From development of heritable cardiomyopathies to gene and precision therapies. | J Cardiovasc Pharmacol | 2026 | 42411452 | PubTator, text mining | PubMed |
| Sex and Age Specific Genetic Risk Across the Dilated and Arrhythmogenic Cardiomyopathy Spectrum: Insights From the SHaRe Registry. | J Am Coll Cardiol | 2026 | 42159538 | PubTator, text mining | PubMed |
| Antihypertensive Drug Target Genes and Epithelial Ovarian Cancer Risk: A Two-Sample Mendelian Randomization Study. | Int J Womens Health | 2026 | 41908841 | PubTator, text mining | PubMed |
| Leveraging Large and Diverse Biobanks to Evaluate Gene-Disease Associations in Hypertrophic Cardiomyopathy. | J Pers Med | 2026 | 41893039 | PubTator, text mining | PubMed |
1 to 10 of 1,417
See all 1,417 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/7134
GET https://conductscience.org/api/genes/v1/7134/patents?page=2