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Gene · 7134

TNNC1: troponin C1, slow skeletal and cardiac type

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TNNC1: troponin C1, slow skeletal and cardiac type. Genes, record 7134. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7134

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Gene

Symbol
TNNC1
HGNC
Name
troponin C1, slow skeletal and cardiac type
HGNC
NCBI Gene ID
7134
NCBI Gene
HGNC ID
HGNC:11943
HGNC
Ensembl
ENSG00000114854
NCBI Gene
Aliases
CMD1Z, CMH13, TN-C, TNC, TNNC
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P63316Troponin C, slow skeletal and cardiac muscles16161Ensembl, GeneID, HGNC

Source UniProt

Patents32

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1468343P63316Espacenet
JP 2025022885 A2025-02-144P63316Espacenet
JP 2025013795 A2025-01-287P63316Espacenet
JP 2024545507 A2024-12-091P63316Espacenet
KR 1020240160200 A2024-11-083P63316Espacenet
EP 4444893 A12024-10-161P63316Espacenet
US 11965885 B22024-04-2331P63316Espacenet
JP 2023123507 A2023-09-05241P63316Espacenet
US 11446398 B22022-09-2093030P63316Espacenet
JP 2022524081 A2022-04-27196001P63316Espacenet

1 to 10 of 32

See all 32 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
LEVOSIMENDANCHEMBL2051955Troponin, cardiac muscle positive modulatorPOSITIVE MODULATOR

Source ChEMBL

Trials41

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07436689LEVOSIMENDANPHASE3ClinicalTrials.gov
NCT07288398LEVOSIMENDANPHASE3ClinicalTrials.gov
NCT07186062LEVOSIMENDANClinicalTrials.gov
NCT06478667LEVOSIMENDANPHASE3ClinicalTrials.gov
NCT06021587LEVOSIMENDANClinicalTrials.gov
NCT05983250LEVOSIMENDANPHASE3ClinicalTrials.gov
NCT05768230LEVOSIMENDANPHASE2/PHASE3ClinicalTrials.gov
NCT05730907LEVOSIMENDANClinicalTrials.gov
NCT04728932LEVOSIMENDANPHASE3ClinicalTrials.gov
NCT04718350LEVOSIMENDANClinicalTrials.gov

1 to 10 of 41

See all 41 trials

NIH grants840

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTNNC1 papersNewest fiscal year
R01HL075619Integrative Approach to Divergent Remodeling in Thin Filament Cardiomyopathies62025
U24HG009650The Clinical Genome Resource – Advancing genomic medicine through biocuration and expert assessment of genes and variants at scale52025
P30DK020572Michigan Diabetes Research Center (MDRC)32025
R01HL113006Human Induced Pluripotent Stem Cells for Cardiovascular Disease Modeling32025
R01HL132401Mechanisms and Therapeutic Targeting of DNA Damage in Dilated Cardiomyopathy Caused by LMNA Mutations32025
R01HL081753Genetic Studies of Sarcomere-based Cardiac Diseases22025
R01HL105826Fast myosin binding protein-C and cardiac contractility in heart failure22025
R01HL128368Engineered Stem Cells for Cardiac Repair22025
R01HL130020Elucidating Mechanism of Cardiac Fibrosis with Cell Village of Pooled Human iPSCs22025
R01HL132874Myofilaments as regulators of heart function in disease22025

1 to 10 of 840Source NIH's project files

See all 840 nih grants

Papers1,417

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Clinical Characteristics and Outcomes of Hypertrophic Cardiomyopathy Associated With Thin Filament Variants: Insights From the SHaRe Registry.Circ Genom Precis Med202642779549PubTator, text miningPubMed
Myosin-binding protein C N-terminal domains slow Ca2+ dissociation from cardiac thin filaments.J Biol Chem202642778103PubTator, text miningPubMed
Aberrant myocardial calcium cycling: pathogenic mechanisms and targeted therapeutics for heart failure.Front Cardiovasc Med202642769728PubTator, text miningPubMed
Construction and validation of a nomogram for the diagnosis of postmenopausal osteoporosis.Mol Med Rep202642596822PubTator, text miningPubMed
Evolutionary and physics-guided modulation of Ca 2 + sensitivity in Cardiac troponin C.J Mol Model202642484751PubTator, text miningPubMed
Contractility Drives Cardiomyocyte Maturation and the Response to Nanopatterns.Circ Res202642422954PubTator, text miningPubMed
The Cardiac Sarcomere: From development of heritable cardiomyopathies to gene and precision therapies.J Cardiovasc Pharmacol202642411452PubTator, text miningPubMed
Sex and Age Specific Genetic Risk Across the Dilated and Arrhythmogenic Cardiomyopathy Spectrum: Insights From the SHaRe Registry.J Am Coll Cardiol202642159538PubTator, text miningPubMed
Antihypertensive Drug Target Genes and Epithelial Ovarian Cancer Risk: A Two-Sample Mendelian Randomization Study.Int J Womens Health202641908841PubTator, text miningPubMed
Leveraging Large and Diverse Biobanks to Evaluate Gene-Disease Associations in Hypertrophic Cardiomyopathy.J Pers Med202641893039PubTator, text miningPubMed

1 to 10 of 1,417

See all 1,417 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/7134

GET https://conductscience.org/api/genes/v1/7134/patents?page=2