ConductScience.org, home

Gene · 7224

TRPC5: transient receptor potential cation channel subfamily C member 5

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. TRPC5: transient receptor potential cation channel subfamily C member 5. Genes, record 7224. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7224

On this page

Gene

Symbol
TRPC5
HGNC
Name
transient receptor potential cation channel subfamily C member 5
HGNC
NCBI Gene ID
7224
NCBI Gene
HGNC ID
HGNC:12337
HGNC
Ensembl
ENSG00000072315
NCBI Gene
Aliases
PPP1R159, TRP5
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9UL62Short transient receptor potential channel 597330Ensembl, GeneID, HGNC

Source UniProt

Patents18

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1467605Q9UL62Espacenet
EP 4641201 A22025-10-291697Q9UL62Espacenet
JP 2025529142 A2025-09-045065Q9UL62Espacenet
US 12371689 B22025-07-295065Q9UL62Espacenet
JP 2025517969 A2025-06-121697Q9UL62Espacenet
JP 2025032204 A2025-03-1137719Q9UL62Espacenet
EP 4461818 A22024-11-1337719Q9UL62Espacenet
JP 2023058610 A2023-04-2537719Q9UL62Espacenet
US 11446398 B22022-09-2090299Q9UL62Espacenet
US 11400116 B22022-08-023785Q9UL62Espacenet

1 to 10 of 18

See all 18 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants663

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTRPC5 papersNewest fiscal year
ZIADE000438Molecular Mechanisms Regulating Calcium Flux In Salivary Glands112025
R01DE017102TRPC1, Calcium, and Saliva Secretion62025
R01DK099465Mechanisms of disrupted homeostasis and kidney injury62025
R01DK095045Molecular mechanisms of podocyte injury in FSGS52025
P30CA016672Cancer Center Support Grant32025
P30EY014800University of Utah Core Vision Research Grant32025
R01EY027920Molecular mechanisms of mechanotransduction in the aqueous outflow pathway32025
T32EY024234Vision Research Training Grant at the University of Utah32025
ZIABC011470Development of Natural Product Leads as Anticancer Therapeutics32025
ZIAHD000195Intracellular Signaling In Endocrine Cells32025

1 to 10 of 663Source NIH's project files

See all 663 nih grants

Papers1,386

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Targeting the Medial Prefrontal Cortex with Transcranial Focused Ultrasound Alleviates Adolescent Sleep-Deprivation-Induced Persistent Postsurgical Pain in Adulthood.Research (Wash D C)202642781091PubTator, text miningPubMed
TRPC5 as a modulator of TRPV1 signalling in pathological pain states.Neuropharmacology202642385945PubTator, text miningPubMed
Distinctly altered TRPC3 and TRPC6 expression patterns in human Alzheimer's disease cortex and hippocampus.Brain Pathol202642373097PubTator, text miningPubMed
Baroreceptor Mechanotransduction: Diverse Sensors, Unified Signals.Hypertension202642261674PubTator, text miningPubMed
Transient Receptor Potential (TRP) channels: Quantitative biophysical correlates of cognitive function across brain regions.Behav Brain Res202642173407PubTator, text miningPubMed
(-)-Englerin A binding to human TRPC5 exposes an aromatic interaction network in channel activation.Nat Commun202642056091PubTator, text miningPubMed
Reactive oxygen species (ROS) in cancer: from mechanism to therapeutic implications.Signal Transduct Target Ther202641881983PubTator, text miningPubMed
ICAM-1 targeted extracellular vesicles loaded with HC-070 mitigate vascular oxidative stress and inflammation in obstructive sleep apnea hypopnea syndrome by inhibiting TRPC5.Free Radic Biol Med202641833586PubTator, text miningPubMed
Molecular hydrogen triggers TRPC4-TRPC4AP-dependent reversible calcium transients via extracellular influx.Theranostics202641799190PubTator, text miningPubMed
Cold exposure and human metabolism: A heterogeneous response across tissues and organs.Temperature (Austin)202641797814PubTator, text miningPubMed

1 to 10 of 1,386

See all 1,386 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/7224

GET https://conductscience.org/api/genes/v1/7224/patents