Gene · 7224
TRPC5: transient receptor potential cation channel subfamily C member 5
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. TRPC5: transient receptor potential cation channel subfamily C member 5. Genes, record 7224. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7224
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9UL62 | Short transient receptor potential channel 5 | 973 | 30 | Ensembl, GeneID, HGNC |
Source UniProt
Patents18
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 67605 | Q9UL62 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 1697 | Q9UL62 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 5065 | Q9UL62 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 5065 | Q9UL62 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 1697 | Q9UL62 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 37719 | Q9UL62 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 37719 | Q9UL62 | Espacenet |
| JP 2023058610 A | 2023-04-25 | 37719 | Q9UL62 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 90299 | Q9UL62 | Espacenet |
| US 11400116 B2 | 2022-08-02 | 3785 | Q9UL62 | Espacenet |
1 to 10 of 18
See all 18 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants663
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | TRPC5 papers | Newest fiscal year |
|---|---|---|---|
| ZIADE000438 | Molecular Mechanisms Regulating Calcium Flux In Salivary Glands | 11 | 2025 |
| R01DE017102 | TRPC1, Calcium, and Saliva Secretion | 6 | 2025 |
| R01DK099465 | Mechanisms of disrupted homeostasis and kidney injury | 6 | 2025 |
| R01DK095045 | Molecular mechanisms of podocyte injury in FSGS | 5 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 3 | 2025 |
| P30EY014800 | University of Utah Core Vision Research Grant | 3 | 2025 |
| R01EY027920 | Molecular mechanisms of mechanotransduction in the aqueous outflow pathway | 3 | 2025 |
| T32EY024234 | Vision Research Training Grant at the University of Utah | 3 | 2025 |
| ZIABC011470 | Development of Natural Product Leads as Anticancer Therapeutics | 3 | 2025 |
| ZIAHD000195 | Intracellular Signaling In Endocrine Cells | 3 | 2025 |
1 to 10 of 663Source NIH's project files
See all 663 nih grantsPapers1,386
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Targeting the Medial Prefrontal Cortex with Transcranial Focused Ultrasound Alleviates Adolescent Sleep-Deprivation-Induced Persistent Postsurgical Pain in Adulthood. | Research (Wash D C) | 2026 | 42781091 | PubTator, text mining | PubMed |
| TRPC5 as a modulator of TRPV1 signalling in pathological pain states. | Neuropharmacology | 2026 | 42385945 | PubTator, text mining | PubMed |
| Distinctly altered TRPC3 and TRPC6 expression patterns in human Alzheimer's disease cortex and hippocampus. | Brain Pathol | 2026 | 42373097 | PubTator, text mining | PubMed |
| Baroreceptor Mechanotransduction: Diverse Sensors, Unified Signals. | Hypertension | 2026 | 42261674 | PubTator, text mining | PubMed |
| Transient Receptor Potential (TRP) channels: Quantitative biophysical correlates of cognitive function across brain regions. | Behav Brain Res | 2026 | 42173407 | PubTator, text mining | PubMed |
| (-)-Englerin A binding to human TRPC5 exposes an aromatic interaction network in channel activation. | Nat Commun | 2026 | 42056091 | PubTator, text mining | PubMed |
| Reactive oxygen species (ROS) in cancer: from mechanism to therapeutic implications. | Signal Transduct Target Ther | 2026 | 41881983 | PubTator, text mining | PubMed |
| ICAM-1 targeted extracellular vesicles loaded with HC-070 mitigate vascular oxidative stress and inflammation in obstructive sleep apnea hypopnea syndrome by inhibiting TRPC5. | Free Radic Biol Med | 2026 | 41833586 | PubTator, text mining | PubMed |
| Molecular hydrogen triggers TRPC4-TRPC4AP-dependent reversible calcium transients via extracellular influx. | Theranostics | 2026 | 41799190 | PubTator, text mining | PubMed |
| Cold exposure and human metabolism: A heterogeneous response across tissues and organs. | Temperature (Austin) | 2026 | 41797814 | PubTator, text mining | PubMed |
1 to 10 of 1,386
See all 1,386 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/7224
GET https://conductscience.org/api/genes/v1/7224/patents