Gene · 7226
TRPM2: transient receptor potential cation channel subfamily M member 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. TRPM2: transient receptor potential cation channel subfamily M member 2. Genes, record 7226. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7226
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O94759 | Transient receptor potential cation channel subfamily M member 2 | 1,503 | 15 | Ensembl, GeneID, HGNC |
Source UniProt
Patents32
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 67613 | O94759 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 67614 | O94759 | Espacenet |
| EP 4640849 A2 | 2025-10-29 | 520 | O94759 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 3586 | O94759 | Espacenet |
| EP 4641202 A2 | 2025-10-29 | 206 | O94759 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 5069 | O94759 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 5069 | O94759 | Espacenet |
| JP 2025519096 A | 2025-06-24 | 520 | O94759 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 3586 | O94759 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 37730 | O94759 | Espacenet |
1 to 10 of 32
See all 32 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants859
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | TRPM2 papers | Newest fiscal year |
|---|---|---|---|
| R01DE017102 | TRPC1, Calcium, and Saliva Secretion | 6 | 2025 |
| R01CA206573 | Structure and function of Transient Receptor Potential Channels | 5 | 2025 |
| ZIADE000438 | Molecular Mechanisms Regulating Calcium Flux In Salivary Glands | 5 | 2025 |
| P20GM103466 | HAWAII INBRE V PROGRAM | 4 | 2025 |
| R01GM088790 | Functional architecture of intracellular Ca2+ signals | 4 | 2025 |
| R01HL045638 | Programming of PMN host-defense function during transendothelial migration | 4 | 2025 |
| R01NS107253 | Single-Particle Cryo-EM Characterization of AMPA Receptor Functional States | 4 | 2025 |
| T32HL007829 | Training Program in Lung Biology and Pathobiology | 4 | 2025 |
| P30ES005605 | Environmental Health Sciences Research Center | 3 | 2025 |
| P30ES006694 | Southwest Environmental Health Sciences Center | 3 | 2025 |
1 to 10 of 859Source NIH's project files
See all 859 nih grantsPapers2,111
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Ginkgolide B Attenuates 6-Hydroxydopamine-Induced Cellular Damage and Modulates Oxidant-Evoked Ca2+ Signalling in SH-SY5Y Cells. | Curr Issues Mol Biol | 2026 | 42793302 | PubTator, text mining | PubMed |
| Brain-derived neurotrophic factor via TRPM2 inhibition reduces amyloid-beta-mediated increases of apoptosis and mitochondrial oxidative neurotoxicity in neuronal cells. | Metab Brain Dis | 2026 | 42720842 | PubTator, text mining | PubMed |
| Planned Ethanol Consumption in Pregnancy: Impact on Offspring Cardiac Autophagic Pathway via TRPM2 Channels-Implications for Fetal Alcohol Syndrome-Linked Cardiological Disorders. | J Appl Toxicol | 2026 | 42656179 | PubTator, text mining | PubMed |
| Psalmotoxin-1, a novel TRPM2 channel antagonist, reduces age-related macular degeneration-caused mitochondrial oxidative damage and apoptosis in human retinal pigment epithelial (ARPE-19) cells. | Graefes Arch Clin Exp Ophthalmol | 2026 | 42560501 | PubTator, text mining | PubMed |
| Neuroinflammation- molecular target based therapeutic approach. | Adv Protein Chem Struct Biol | 2026 | 42448410 | PubTator, text mining | PubMed |
| TRPM2 Deficiency Attenuates Allergic Rhinitis-Like Inflammation With Altered Ca2+-NFAT Signaling, Treg Responses, and sIgE Production. | Immun Inflamm Dis | 2026 | 42438241 | PubTator, text mining | PubMed |
| Integrative single-cell and multi-omics analysis of ZBTB21-mediated serine metabolism in colorectal cancer: from metabolic reprogramming to immune microenvironment modulation. | Cancer Immunol Immunother | 2026 | 42400616 | PubTator, text mining | PubMed |
| Sinapic Acid Reduces Hypoxia-Induced Cell Damage in Hep-2 Cells by Regulating TRPM2 Channel Activation. | J Biochem Mol Toxicol | 2026 | 42345509 | PubTator, text mining | PubMed |
| Liver-brain axis mechanism underlying central immune remodeling triggered by peripheral hepatic damage. | Cell Signal | 2026 | 42242572 | PubTator, text mining | PubMed |
| Corrigendum to " Knockdown of TRPM2 promotes osteogenic differentiation of Human Periodontal Ligament Stem Cells by modulating NF-κB /NLRP3 pathway", Tissue Cell, 2023, 84: 102184. | Tissue Cell | 2026 | 42236400 | PubTator, text mining | PubMed |
1 to 10 of 2,111
See all 2,111 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/7226
GET https://conductscience.org/api/genes/v1/7226/patents?page=2