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Gene · 7226

TRPM2: transient receptor potential cation channel subfamily M member 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TRPM2: transient receptor potential cation channel subfamily M member 2. Genes, record 7226. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7226

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Gene

Symbol
TRPM2
HGNC
Name
transient receptor potential cation channel subfamily M member 2
HGNC
NCBI Gene ID
7226
NCBI Gene
HGNC ID
HGNC:12339
HGNC
Ensembl
ENSG00000142185
NCBI Gene
Aliases
EREG1, KNP3, LTRPC2, LTrpC-2, NUDT9H, NUDT9L1, TRPC7
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O94759Transient receptor potential cation channel subfamily M member 21,50315Ensembl, GeneID, HGNC

Source UniProt

Patents32

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1467613O94759Espacenet
JP 2026004568 A2026-01-1467614O94759Espacenet
EP 4640849 A22025-10-29520O94759Espacenet
EP 4641201 A22025-10-293586O94759Espacenet
EP 4641202 A22025-10-29206O94759Espacenet
JP 2025529142 A2025-09-045069O94759Espacenet
US 12371689 B22025-07-295069O94759Espacenet
JP 2025519096 A2025-06-24520O94759Espacenet
JP 2025517969 A2025-06-123586O94759Espacenet
JP 2025032204 A2025-03-1137730O94759Espacenet

1 to 10 of 32

See all 32 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants859

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTRPM2 papersNewest fiscal year
R01DE017102TRPC1, Calcium, and Saliva Secretion62025
R01CA206573Structure and function of Transient Receptor Potential Channels52025
ZIADE000438Molecular Mechanisms Regulating Calcium Flux In Salivary Glands52025
P20GM103466HAWAII INBRE V PROGRAM42025
R01GM088790Functional architecture of intracellular Ca2+ signals42025
R01HL045638Programming of PMN host-defense function during transendothelial migration42025
R01NS107253Single-Particle Cryo-EM Characterization of AMPA Receptor Functional States42025
T32HL007829Training Program in Lung Biology and Pathobiology42025
P30ES005605Environmental Health Sciences Research Center32025
P30ES006694Southwest Environmental Health Sciences Center32025

1 to 10 of 859Source NIH's project files

See all 859 nih grants

Papers2,111

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Ginkgolide B Attenuates 6-Hydroxydopamine-Induced Cellular Damage and Modulates Oxidant-Evoked Ca2+ Signalling in SH-SY5Y Cells.Curr Issues Mol Biol202642793302PubTator, text miningPubMed
Brain-derived neurotrophic factor via TRPM2 inhibition reduces amyloid-beta-mediated increases of apoptosis and mitochondrial oxidative neurotoxicity in neuronal cells.Metab Brain Dis202642720842PubTator, text miningPubMed
Planned Ethanol Consumption in Pregnancy: Impact on Offspring Cardiac Autophagic Pathway via TRPM2 Channels-Implications for Fetal Alcohol Syndrome-Linked Cardiological Disorders.J Appl Toxicol202642656179PubTator, text miningPubMed
Psalmotoxin-1, a novel TRPM2 channel antagonist, reduces age-related macular degeneration-caused mitochondrial oxidative damage and apoptosis in human retinal pigment epithelial (ARPE-19) cells.Graefes Arch Clin Exp Ophthalmol202642560501PubTator, text miningPubMed
Neuroinflammation- molecular target based therapeutic approach.Adv Protein Chem Struct Biol202642448410PubTator, text miningPubMed
TRPM2 Deficiency Attenuates Allergic Rhinitis-Like Inflammation With Altered Ca2+-NFAT Signaling, Treg Responses, and sIgE Production.Immun Inflamm Dis202642438241PubTator, text miningPubMed
Integrative single-cell and multi-omics analysis of ZBTB21-mediated serine metabolism in colorectal cancer: from metabolic reprogramming to immune microenvironment modulation.Cancer Immunol Immunother202642400616PubTator, text miningPubMed
Sinapic Acid Reduces Hypoxia-Induced Cell Damage in Hep-2 Cells by Regulating TRPM2 Channel Activation.J Biochem Mol Toxicol202642345509PubTator, text miningPubMed
Liver-brain axis mechanism underlying central immune remodeling triggered by peripheral hepatic damage.Cell Signal202642242572PubTator, text miningPubMed
Corrigendum to " Knockdown of TRPM2 promotes osteogenic differentiation of Human Periodontal Ligament Stem Cells by modulating NF-κB /NLRP3 pathway", Tissue Cell, 2023, 84: 102184.Tissue Cell202642236400PubTator, text miningPubMed

1 to 10 of 2,111

See all 2,111 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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