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Gene · 7468

NSD2: nuclear receptor binding SET domain protein 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. NSD2: nuclear receptor binding SET domain protein 2. Genes, record 7468. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7468

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Gene

Symbol
NSD2
HGNC
Name
nuclear receptor binding SET domain protein 2
HGNC
NCBI Gene ID
7468
NCBI Gene
HGNC ID
HGNC:12766
HGNC
Ensembl
ENSG00000109685
NCBI Gene
Aliases
KMT3F, KMT3G, MMSET, RAUST, REIIBP, TRX5, WHS, WHSC1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O96028Histone-lysine N-methyltransferase NSD21,36522Ensembl, GeneID, HGNC

Source UniProt

Patents70

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1469943O96028Espacenet
JP 2026004568 A2026-01-1469944O96028Espacenet
JP 2026004568 A2026-01-1469945O96028Espacenet
JP 2026004568 A2026-01-1469951O96028Espacenet
EP 4650780 A22025-11-1910588O96028Espacenet
EP 4641201 A22025-10-2910946O96028Espacenet
JP 2025147176 A2025-10-0615837O96028Espacenet
JP 2025517969 A2025-06-1210946O96028Espacenet
JP 2025517970 A2025-06-1210588O96028Espacenet
JP 2025028160 A2025-02-2815837O96028Espacenet

1 to 10 of 70

See all 70 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,474

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleNSD2 papersNewest fiscal year
P30CA008748Cancer Center Support Grant372025
P50CA186781Mayo Clinic Multiple Myeloma SPORE232025
P01CA155258Integrative Oncogenomics of Multiple Myeloma152025
P30CA016672Cancer Center Support Grant132025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center122025
I01BX001584Molecular Manipulation to Enhance Anti-Myeloma Response82025
P30CA016087Cancer Center Support Grant82025
P30CA021765Cancer Center Support Grant (CCSG)82025
P30CA086862Cancer Center Support Grant82025
R01AI118891Viral modulation of epitranscriptomic mechanisms82025

1 to 10 of 1,474Source NIH's project files

See all 1,474 nih grants

Papers2,351

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
NSD2 drives triple-negative breast cancer progression via ATAD3A-dependent senescence.Cell Signal202642822681PubTator, text miningPubMed
NSD Histone Methyltransferases in Solid Tumors: Biological Functions, Oncogenic Mechanisms and Therapeutic Targeting.Int J Mol Sci202642794546PubTator, text miningPubMed
Degrading NSD2 rewires the myeloma niche.Blood202642783363PubTator, text miningPubMed
Rauch-Steindl syndrome: intrauterine phenotype and diagnostic utility of prenatal exome sequencing.BMJ Case Rep202642754354PubTator, text miningPubMed
Genomic Characterization of ETV6::RUNX1-Positive Childhood B-ALL in a Chinese Cohort: Novel Fusion Partners, Co-Occurring Mutations, and Risk-Stratifying Biomarkers.Pediatr Blood Cancer202642720515PubTator, text miningPubMed
Phenotypes of Hereditary Diseases Associated With Rauch-Steindl Syndrome.Hum Mutat202642694379PubTator, text miningPubMed
Expanding the Molecular Spectrum of Papillary Renal Neoplasm With Reverse Polarity: A Report of Two Cases and a Literature Review.Cureus202642602752PubTator, text miningPubMed
Alternative Splicing in Cyclin-Dependent Kinase 4/6 Inhibitor Resistance in Estrogen Receptor-Positive Breast Cancer.Drug Dev Res202642574086PubTator, text miningPubMed
Degraders of histone lysine methyltransferases: Progress, challenges, and opportunities.Drug Discov Today202642542162PubTator, text miningPubMed
NSD2 is a critical regulator of Erastin-induced ferroptosis in keratinocytes.Free Radic Biol Med202642462913PubTator, text miningPubMed

1 to 10 of 2,351

See all 2,351 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/7468

GET https://conductscience.org/api/genes/v1/7468/patents?page=2