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Gene · 7498

XDH: xanthine dehydrogenase

11 sourcesgene-search-2026-11-11-0.1.0

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ConductScience Library. XDH: xanthine dehydrogenase. Genes, record 7498. Release gene-search-2026-11-11-0.1.0, 11 Nov 2026. https://conductscience.org/library/genes/7498

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Gene

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

Symbol
XDH
HGNC
Name
xanthine dehydrogenase
HGNC
NCBI Gene ID
7498
NCBI Gene
HGNC ID
HGNC:12805
HGNC
Ensembl
ENSG00000158125
NCBI Gene
Aliases
XAN1, XDH/XO, XO, XOR
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P47989Xanthine dehydrogenase/oxidase1,3332Ensembl, GeneID, HGNC

Source UniProt

Patents39

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026067851 A2026-04-21364P47989Espacenet
JP 2026004568 A2026-01-1470008P47989Espacenet
EP 4650780 A22025-11-1910160P47989Espacenet
EP 4641201 A22025-10-2910457P47989Espacenet
JP 2025517969 A2025-06-1210457P47989Espacenet
JP 2025517970 A2025-06-1210160P47989Espacenet
JP 2023521663 A2023-05-25363P47989Espacenet
US 11446398 B22022-09-2097954P47989Espacenet
JP 2022524081 A2022-04-27200925P47989Espacenet
JP 2021530985 A2021-11-18471P47989Espacenet

1 to 10 of 39

See all 39 patents

Drugs6

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ALLOPURINOLCHEMBL1467Xanthine dehydrogenase inhibitorINHIBITORChEMBL
ALLOPURINOL SODIUMCHEMBL1200477Xanthine dehydrogenase inhibitorINHIBITORChEMBL
BENDAZACCHEMBL1089221Xanthine dehydrogenase inhibitorINHIBITORChEMBL
FEBUXOSTATCHEMBL1164729Xanthine dehydrogenase inhibitorINHIBITORChEMBL
OXYPURINOLCHEMBL859Xanthine dehydrogenase inhibitorINHIBITORChEMBL
TOPIROXOSTATCHEMBL1078685Xanthine dehydrogenase inhibitorINHIBITORChEMBL

Trials166

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

1 to 10 of 166

See all 166 trials

NIH grants1,726

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal year
ZIADK025104Clinical Applications of Nitrite and Nitrate162025
R01HL098032Omics, mice and men: Development of precision transfusion medicine132025
P30CA046934University of Colorado Cancer Center Support Grant72025
P30ES019776HERCULES: Exposome Research Center62025
P30CA016672Cancer Center Support Grant42025
P42ES004911Environmental, Microbial and Mammalian Biomolecular Responses to AhR Ligands42025
R01DK097253Glomerular Cell-Cell Crosstalk and Injury42025
R01GM057378Spectroscopic Studies of Molybdoenzymes & Models42025
R24AA019661CoPARC: Colorado Pulmonary-Alcohol Research Collaborative42025
K12HD052892Molecular Basis of Pediatric Disease32025

1 to 10 of 1,726Source NIH's project files

See all 1,726 nih grants

Papers4,562

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42805907PubTator, text miningPubMed
42741484PubTator, text miningPubMed
42736651PubTator, text miningPubMed
42735627PubTator, text miningPubMed
42724844PubTator, text miningPubMed
42723167PubTator, text miningPubMed
42712219PubTator, text miningPubMed
42684660PubTator, text miningPubMed
42650257PubTator, text miningPubMed
42628940PubTator, text miningPubMed

1 to 10 of 4,562

See all 4,562 papers

Sources 11

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNone stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GeneNone named. Public domain as US government information
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/7498

GET https://conductscience.org/api/genes/v1/7498/patents?page=2