Gene · 7518
XRCC4: X-ray repair cross complementing 4
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. XRCC4: X-ray repair cross complementing 4. Genes, record 7518. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7518
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q13426 | DNA repair protein XRCC4 | 336 | 36 | Ensembl, GeneID, HGNC |
Source UniProt
Patents46
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 6696 | Q13426 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 6696 | Q13426 | Espacenet |
| JP 2025011252 A | 2025-01-23 | 6 | Q13426 | Espacenet |
| EP 4464338 A2 | 2024-11-20 | 286 | Q13426 | Espacenet |
| JP 2024123008 A | 2024-09-10 | 9139 | Q13426 | Espacenet |
| JP 2024123008 A | 2024-09-10 | 9141 | Q13426 | Espacenet |
| US 11976334 B2 | 2024-05-07 | 221 | Q13426 | Espacenet |
| US 11680268 B2 | 2023-06-20 | 286 | Q13426 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 98055 | Q13426 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 98057 | Q13426 | Espacenet |
1 to 10 of 46
See all 46 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,847
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | XRCC4 papers | Newest fiscal year |
|---|---|---|---|
| P01CA092584 | Structural Cell Biology of DNA Repair Machines | 76 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 25 | 2025 |
| R35GM118009 | Site-Specific Recombination in Human Health & Disease | 17 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 16 | 2025 |
| P30CA118100 | University of New Mexico Cancer Center Support Grant | 13 | 2025 |
| R01ES012512 | Roles of Lig3 and XRCC1 Genes in Genome Stability | 12 | 2025 |
| R01CA097096 | DNA Polymerases in Nonhomologous End Joining | 9 | 2025 |
| R01AI020047 | Mechanisms That Control Antigen Receptor Variable Region Exon Assembly | 8 | 2025 |
| ZIAES065070 | Structure-Function Studies Of DNA Replication Fidelity | 8 | 2025 |
| P30CA033572 | Cancer Center Support Grant | 7 | 2025 |
1 to 10 of 1,847Source NIH's project files
See all 1,847 nih grantsPapers3,098
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Cellular effects of silver diamine fluoride in oral cells. | J Oral Biosci | 2026 | 42822289 | PubTator, text mining | PubMed |
| Non-syndromic premature ovarian insufficiency associated with monoallelic LIG4 mutation via haploinsufficiency. | J Ovarian Res | 2026 | 42343416 | PubTator, text mining | PubMed |
| Systematic discovery of UFM1 receptors reveals a regulatory module in DNA repair directing non-homologous end-joining. | Nat Commun | 2026 | 42297806 | PubTator, text mining | PubMed |
| Evaluation of XRCC4 and VEGF Gene Variants in Relation to Breast Cancer Risk in a Jordanian Cohort. | Cancer Manag Res | 2026 | 42255530 | PubTator, text mining | PubMed |
| Lesions initiating spontaneous mitotic crossover are minimally subject to non-homologous end joining. | bioRxiv | 2026 | 42182344 | PubTator, text mining | PubMed |
| Genome-wide mapping of Cas9-induced sister chromatid exchange across single and over 200 genomic targets. | bioRxiv | 2026 | 42182287 | PubTator, text mining | PubMed |
| Protein arginine methyltransferases in cancer: mechanisms, functions, and therapeutic opportunities. | J Biomed Sci | 2026 | 41928257 | PubTator, text mining | PubMed |
| TDP-43 related amyotrophic lateral sclerosis-frontotemporal dementia and links to the DNA damage response: a systematic review and narrative synthesis. | Front Mol Neurosci | 2026 | 41924615 | PubTator, text mining | PubMed |
| An Update on Inborn Errors of V(D)J Recombination. | Physiology (Bethesda) | 2026 | 41902554 | PubTator, text mining | PubMed |
| Nonhomologous end joining-the importance of end tethering and beyond. | Genes Dev | 2026 | 41871908 | PubTator, text mining | PubMed |
1 to 10 of 3,098
See all 3,098 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/7518
GET https://conductscience.org/api/genes/v1/7518/patents?page=2