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Gene · 7518

XRCC4: X-ray repair cross complementing 4

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. XRCC4: X-ray repair cross complementing 4. Genes, record 7518. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7518

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Gene

Symbol
XRCC4
HGNC
Name
X-ray repair cross complementing 4
HGNC
NCBI Gene ID
7518
NCBI Gene
HGNC ID
HGNC:12831
HGNC
Ensembl
ENSG00000152422
NCBI Gene
Aliases
SSMED, hXRCC4
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q13426DNA repair protein XRCC433636Ensembl, GeneID, HGNC

Source UniProt

Patents46

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-196696Q13426Espacenet
JP 2025517970 A2025-06-126696Q13426Espacenet
JP 2025011252 A2025-01-236Q13426Espacenet
EP 4464338 A22024-11-20286Q13426Espacenet
JP 2024123008 A2024-09-109139Q13426Espacenet
JP 2024123008 A2024-09-109141Q13426Espacenet
US 11976334 B22024-05-07221Q13426Espacenet
US 11680268 B22023-06-20286Q13426Espacenet
US 11446398 B22022-09-2098055Q13426Espacenet
US 11446398 B22022-09-2098057Q13426Espacenet

1 to 10 of 46

See all 46 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,847

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleXRCC4 papersNewest fiscal year
P01CA092584Structural Cell Biology of DNA Repair Machines762025
P30CA016672Cancer Center Support Grant252025
R35GM118009Site-Specific Recombination in Human Health & Disease172025
P30CA008748Cancer Center Support Grant162025
P30CA118100University of New Mexico Cancer Center Support Grant132025
R01ES012512Roles of Lig3 and XRCC1 Genes in Genome Stability122025
R01CA097096DNA Polymerases in Nonhomologous End Joining92025
R01AI020047Mechanisms That Control Antigen Receptor Variable Region Exon Assembly82025
ZIAES065070Structure-Function Studies Of DNA Replication Fidelity82025
P30CA033572Cancer Center Support Grant72025

1 to 10 of 1,847Source NIH's project files

See all 1,847 nih grants

Papers3,098

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Cellular effects of silver diamine fluoride in oral cells.J Oral Biosci202642822289PubTator, text miningPubMed
Non-syndromic premature ovarian insufficiency associated with monoallelic LIG4 mutation via haploinsufficiency.J Ovarian Res202642343416PubTator, text miningPubMed
Systematic discovery of UFM1 receptors reveals a regulatory module in DNA repair directing non-homologous end-joining.Nat Commun202642297806PubTator, text miningPubMed
Evaluation of XRCC4 and VEGF Gene Variants in Relation to Breast Cancer Risk in a Jordanian Cohort.Cancer Manag Res202642255530PubTator, text miningPubMed
Lesions initiating spontaneous mitotic crossover are minimally subject to non-homologous end joining.bioRxiv202642182344PubTator, text miningPubMed
Genome-wide mapping of Cas9-induced sister chromatid exchange across single and over 200 genomic targets.bioRxiv202642182287PubTator, text miningPubMed
Protein arginine methyltransferases in cancer: mechanisms, functions, and therapeutic opportunities.J Biomed Sci202641928257PubTator, text miningPubMed
TDP-43 related amyotrophic lateral sclerosis-frontotemporal dementia and links to the DNA damage response: a systematic review and narrative synthesis.Front Mol Neurosci202641924615PubTator, text miningPubMed
An Update on Inborn Errors of V(D)J Recombination.Physiology (Bethesda)202641902554PubTator, text miningPubMed
Nonhomologous end joining-the importance of end tethering and beyond.Genes Dev202641871908PubTator, text miningPubMed

1 to 10 of 3,098

See all 3,098 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/7518

GET https://conductscience.org/api/genes/v1/7518/patents?page=2