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Gene · 762

CA4: carbonic anhydrase 4

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CA4: carbonic anhydrase 4. Genes, record 762. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/762

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Gene

Symbol
CA4
HGNC
Name
carbonic anhydrase 4
HGNC
NCBI Gene ID
762
NCBI Gene
HGNC ID
HGNC:1375
HGNC
Ensembl
ENSG00000167434
NCBI Gene
Aliases
CAIV, Car4, RP17
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P22748Carbonic anhydrase 431210Ensembl, GeneID, HGNC

Source UniProt

Patents48

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026517404 A2026-05-291P22748Espacenet
JP 2026515744 A2026-05-19264P22748Espacenet
EP 4719460 A12026-04-081P22748Espacenet
EP 4713339 A22026-03-251P22748Espacenet
EP 4650780 A22025-11-194029P22748Espacenet
JP 2025529142 A2025-09-04681P22748Espacenet
US 12371689 B22025-07-29681P22748Espacenet
JP 2025517970 A2025-06-124029P22748Espacenet
JP 2025062604 A2025-04-1411722P22748Espacenet
JP 2025508968 A2025-04-10180P22748Espacenet

1 to 10 of 48

See all 48 patents

Drugs7

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ACETAZOLAMIDECHEMBL20Carbonic anhydrase IV inhibitorINHIBITORChEMBL
ACETAZOLAMIDE SODIUMCHEMBL1200814Carbonic anhydrase IV inhibitorINHIBITORChEMBL
DICHLORPHENAMIDECHEMBL17Carbonic anhydrase IV inhibitorINHIBITORChEMBL
ETHOXZOLAMIDECHEMBL18Carbonic anhydrase inhibitorINHIBITORChEMBL
METHAZOLAMIDECHEMBL19Carbonic anhydrase IV inhibitorINHIBITORChEMBL
SULTHIAMECHEMBL328560Carbonic anhydrase inhibitorINHIBITORChEMBL
TOPIRAMATECHEMBL220492Carbonic anhydrase IV inhibitorINHIBITORChEMBL

Trials230

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07588750TOPIRAMATEClinicalTrials.gov
NCT07517068ACETAZOLAMIDEEARLY_PHASE1ClinicalTrials.gov
NCT07469722ACETAZOLAMIDEPHASE2/PHASE3ClinicalTrials.gov
NCT07384624TOPIRAMATEPHASE1/PHASE2ClinicalTrials.gov
NCT07372040ACETAZOLAMIDEPHASE2ClinicalTrials.gov
NCT06981234ACETAZOLAMIDEPHASE2ClinicalTrials.gov
NCT06945848ACETAZOLAMIDEClinicalTrials.gov
NCT06919744ACETAZOLAMIDEClinicalTrials.gov
NCT06783166ACETAZOLAMIDEPHASE2/PHASE3ClinicalTrials.gov
NCT06776432ACETAZOLAMIDEPHASE2ClinicalTrials.gov

1 to 10 of 230

See all 230 trials

NIH grants1,287

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCA4 papersNewest fiscal year
P30CA054174Mays Cancer Center at UT Health SA92025
P30CA008748Cancer Center Support Grant72025
P30EY025580Multidisciplinary Investigations in Visual Science72025
R01EY024605Choriocapillaris Protection and Replacement in AMD72025
P30CA016672Cancer Center Support Grant62025
R01CA148706Targeting the colchicine binding site in tubulin for cancer therapy52025
P01AG026276Antecedent Biomarkers for Alzheimer Disease: The Adult Children Study42025
P30CA068485Cancer Center Support Grant32025
P30CA142543UT Southwestern Medical Center Simmons Comprehensive Cancer Center32025
P30DK034987Center for Gastrointestinal Biology and Disease32025

1 to 10 of 1,287Source NIH's project files

See all 1,287 nih grants

Papers2,162

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Genetic architecture of externalizing and internalizing traits in the general population and its link to psychiatric conditions and well-being: a multivariate approach.Eur Neuropsychopharmacol202642679763PubTator, text miningPubMed
Transcriptome-Based Six-Gene Fatty Acid Metabolism Signature for Prognosis and Predicted Immunotherapy Response in Lung Adenocarcinoma: Cross-Population Validation.Genes (Basel)202642650107PubTator, text miningPubMed
CA-IV-directed small-molecule shuttle enables targeted brain delivery of biologics.Nat Chem Biol202642649418PubTator, text miningPubMed
Structural Heterogeneity of TDP-43 Fragments in Alzheimer's Disease and Primary Age-Related Tauopathy by Artificial Intelligence (AI)-Based 3D Segmentation.Neuropathol Appl Neurobiol202642576167PubTator, text miningPubMed
SARS-CoV-2 nucleocapsid protein drives pulmonary injury by enhancing GRP75-dependent ER-mitochondria tethering and reprogramming of alveolar macrophages.Life Sci202642570816PubTator, text miningPubMed
Long-Term Blood Pressure Variability, Hippocampal Subfield Volume and Cognitive Decline: A Population-Based Prospective MRI Study.J Magn Reson Imaging202642561035PubTator, text miningPubMed
Identification of a Duplication in the RP17 Locus in an Individual With Pathogenic CEP290 Variants: Implications for RP17 Variant Classification.Invest Ophthalmol Vis Sci202642545071PubTator, text miningPubMed
Hippocampal volume and white matter impairments in patients with congenital adrenal hyperplasia.J Clin Endocrinol Metab202642535568PubTator, text miningPubMed
Carbonic anhydrases IV and XV.Enzymes202642486554PubTator, text miningPubMed
Comprehensive Spatial Transcriptomic Profiling of Cribriform, Intraductal, Atypical Intraductal Proliferation, and Ductal Adenocarcinoma of the Prostate.Lab Invest202642468875PubTator, text miningPubMed

1 to 10 of 2,162

See all 2,162 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/762

GET https://conductscience.org/api/genes/v1/762/patents?page=2