Gene · 771
CA12: carbonic anhydrase 12
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. CA12: carbonic anhydrase 12. Genes, record 771. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/771
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O43570 | Carbonic anhydrase 12 | 354 | 40 | Ensembl, GeneID, HGNC |
Source UniProt
Patents63
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 40030 | O43570 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 159 | O43570 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 159 | O43570 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 11753 | O43570 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 25793 | O43570 | Espacenet |
| JP 2025503451 A | 2025-02-04 | 6 | O43570 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 25793 | O43570 | Espacenet |
| KR 1020240133798 A | 2024-09-04 | 6 | O43570 | Espacenet |
| US 11820831 B2 | 2023-11-21 | 5 | O43570 | Espacenet |
| JP 2023058610 A | 2023-04-25 | 25793 | O43570 | Espacenet |
1 to 10 of 63
See all 63 patentsDrugs5
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| ACETAZOLAMIDE | CHEMBL20 | Carbonic anhydrase XII inhibitor | INHIBITOR | ChEMBL |
| ACETAZOLAMIDE SODIUM | CHEMBL1200814 | Carbonic anhydrase XII inhibitor | INHIBITOR | ChEMBL |
| DICHLORPHENAMIDE | CHEMBL17 | Carbonic anhydrase XII inhibitor | INHIBITOR | ChEMBL |
| ETHOXZOLAMIDE | CHEMBL18 | Carbonic anhydrase inhibitor | INHIBITOR | ChEMBL |
| SULTHIAME | CHEMBL328560 | Carbonic anhydrase inhibitor | INHIBITOR | ChEMBL |
Trials75
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07517068 | ACETAZOLAMIDE | EARLY_PHASE1 | ClinicalTrials.gov | |
| NCT07469722 | ACETAZOLAMIDE | PHASE2/PHASE3 | ClinicalTrials.gov | |
| NCT07372040 | ACETAZOLAMIDE | PHASE2 | ClinicalTrials.gov | |
| NCT06981234 | ACETAZOLAMIDE | PHASE2 | ClinicalTrials.gov | |
| NCT06945848 | ACETAZOLAMIDE | ClinicalTrials.gov | ||
| NCT06919744 | ACETAZOLAMIDE | ClinicalTrials.gov | ||
| NCT06783166 | ACETAZOLAMIDE | PHASE2/PHASE3 | ClinicalTrials.gov | |
| NCT06776432 | ACETAZOLAMIDE | PHASE2 | ClinicalTrials.gov | |
| NCT06535529 | ACETAZOLAMIDE | PHASE3 | ClinicalTrials.gov | |
| NCT06521476 | ACETAZOLAMIDE | PHASE2 | ClinicalTrials.gov |
1 to 10 of 75
See all 75 trialsNIH grants802
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | CA12 papers | Newest fiscal year |
|---|---|---|---|
| P30CA076292 | Moffitt Cancer Center Support Grant | 7 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 6 | 2025 |
| P30CA006973 | Regional Oncology Research Center | 4 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 4 | 2025 |
| P30DK054759 | Precision Medicine Center for Cystic Fibrosis | 3 | 2025 |
| P30ES005605 | Environmental Health Sciences Research Center | 3 | 2025 |
| R01MH107512 | Development of Memory Networks in Children | 3 | 2025 |
| P30AG066515 | Stanford Alzheimer's Disease Research Center | 2 | 2025 |
| P30CA006927 | Comprehensive Cancer Center Program at Fox Chase | 2 | 2025 |
| P30CA014520 | UW Comprehensive Cancer Center Support | 2 | 2025 |
1 to 10 of 802Source NIH's project files
See all 802 nih grantsPapers1,772
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Evaluation of S100A4, CA-12, CA-9, Annexin A1/A2, and Galectin-3 in Prostate Cancer: Diagnostic and Prognostic Implications. | Asian Pac J Cancer Prev | 2026 | 42808395 | PubTator, text mining | PubMed |
| Enthalpy-entropy compensation in inhibitor binding to carbonic anhydrase isozymes. | Biophys J | 2026 | 42802557 | PubTator, text mining | PubMed |
| Multiscale Transcriptomic and Molecular Modeling Analyses Suggest DCPMU-Associated Epithelial Remodeling and Tumor Microenvironment Perturbation in Prostate Cancer. | Curr Issues Mol Biol | 2026 | 42793291 | PubTator, text mining | PubMed |
| My Love Story With HIFs in the Disc: A Journey to the Humboldt Research Award. | JOR Spine | 2026 | 42694344 | PubTator, text mining | PubMed |
| Explainable Multi-Isoform QSAR, PubChem Concordance, and Applicability-Domain-Guided Prioritization of Selective Human Carbonic Anhydrase I, II, IX, and XII Inhibitors. | Pharmaceuticals (Basel) | 2026 | 42653817 | PubTator, text mining | PubMed |
| Human Nasal and Bronchial Epithelium in Cystic Fibrosis: Differences in Expression of Airway pH Regulatory Proteins. | Pediatr Pulmonol | 2026 | 42591023 | PubTator, text mining | PubMed |
| Clone-By-Clone Therapy Guidance in Luminal Breast Cancer Via Spatial Proteomics and Patient-Derived Tumoroid. | Mol Cell Proteomics | 2026 | 42586237 | PubTator, text mining | PubMed |
| Hedgehog Signaling Regulates Hypoxia-Associated Metabolic Adaptation in Myeloid Leukemia In Vitro Cell Models. | Int J Mol Sci | 2026 | 42511667 | PubTator, text mining | PubMed |
| 1-Aryl-6,7-Dimethoxy-3,4-Dihydroisoquinoline-2(1H)-Sulfonamides as hCA XII Selective Inhibitors: Experimental and Theoretical Studies to Interrogate the Isoform Selectivity. | ChemMedChem | 2026 | 42493249 | PubTator, text mining | PubMed |
| Carbonic anhydrase IX and XII. | Enzymes | 2026 | 42486548 | PubTator, text mining | PubMed |
1 to 10 of 1,772
See all 1,772 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/771
GET https://conductscience.org/api/genes/v1/771/patents?page=2