ConductScience.org, home

Gene · 771

CA12: carbonic anhydrase 12

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. CA12: carbonic anhydrase 12. Genes, record 771. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/771

On this page

Gene

Symbol
CA12
HGNC
Name
carbonic anhydrase 12
HGNC
NCBI Gene ID
771
NCBI Gene
HGNC ID
HGNC:1371
HGNC
Ensembl
ENSG00000074410
NCBI Gene
Aliases
CA-XII, CAXII, HsT18816, T18816
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O43570Carbonic anhydrase 1235440Ensembl, GeneID, HGNC

Source UniProt

Patents63

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1440030O43570Espacenet
EP 4650780 A22025-11-19159O43570Espacenet
JP 2025517970 A2025-06-12159O43570Espacenet
JP 2025062604 A2025-04-1411753O43570Espacenet
JP 2025032204 A2025-03-1125793O43570Espacenet
JP 2025503451 A2025-02-046O43570Espacenet
EP 4461818 A22024-11-1325793O43570Espacenet
KR 1020240133798 A2024-09-046O43570Espacenet
US 11820831 B22023-11-215O43570Espacenet
JP 2023058610 A2023-04-2525793O43570Espacenet

1 to 10 of 63

See all 63 patents

Drugs5

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ACETAZOLAMIDECHEMBL20Carbonic anhydrase XII inhibitorINHIBITORChEMBL
ACETAZOLAMIDE SODIUMCHEMBL1200814Carbonic anhydrase XII inhibitorINHIBITORChEMBL
DICHLORPHENAMIDECHEMBL17Carbonic anhydrase XII inhibitorINHIBITORChEMBL
ETHOXZOLAMIDECHEMBL18Carbonic anhydrase inhibitorINHIBITORChEMBL
SULTHIAMECHEMBL328560Carbonic anhydrase inhibitorINHIBITORChEMBL

Trials75

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07517068ACETAZOLAMIDEEARLY_PHASE1ClinicalTrials.gov
NCT07469722ACETAZOLAMIDEPHASE2/PHASE3ClinicalTrials.gov
NCT07372040ACETAZOLAMIDEPHASE2ClinicalTrials.gov
NCT06981234ACETAZOLAMIDEPHASE2ClinicalTrials.gov
NCT06945848ACETAZOLAMIDEClinicalTrials.gov
NCT06919744ACETAZOLAMIDEClinicalTrials.gov
NCT06783166ACETAZOLAMIDEPHASE2/PHASE3ClinicalTrials.gov
NCT06776432ACETAZOLAMIDEPHASE2ClinicalTrials.gov
NCT06535529ACETAZOLAMIDEPHASE3ClinicalTrials.gov
NCT06521476ACETAZOLAMIDEPHASE2ClinicalTrials.gov

1 to 10 of 75

See all 75 trials

NIH grants802

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCA12 papersNewest fiscal year
P30CA076292Moffitt Cancer Center Support Grant72025
P30CA008748Cancer Center Support Grant62025
P30CA006973Regional Oncology Research Center42025
P30CA016672Cancer Center Support Grant42025
P30DK054759Precision Medicine Center for Cystic Fibrosis32025
P30ES005605Environmental Health Sciences Research Center32025
R01MH107512Development of Memory Networks in Children32025
P30AG066515Stanford Alzheimer's Disease Research Center22025
P30CA006927Comprehensive Cancer Center Program at Fox Chase22025
P30CA014520UW Comprehensive Cancer Center Support22025

1 to 10 of 802Source NIH's project files

See all 802 nih grants

Papers1,772

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Evaluation of S100A4, CA-12, CA-9, Annexin A1/A2, and Galectin-3 in Prostate Cancer: Diagnostic and Prognostic Implications.Asian Pac J Cancer Prev202642808395PubTator, text miningPubMed
Enthalpy-entropy compensation in inhibitor binding to carbonic anhydrase isozymes.Biophys J202642802557PubTator, text miningPubMed
Multiscale Transcriptomic and Molecular Modeling Analyses Suggest DCPMU-Associated Epithelial Remodeling and Tumor Microenvironment Perturbation in Prostate Cancer.Curr Issues Mol Biol202642793291PubTator, text miningPubMed
My Love Story With HIFs in the Disc: A Journey to the Humboldt Research Award.JOR Spine202642694344PubTator, text miningPubMed
Explainable Multi-Isoform QSAR, PubChem Concordance, and Applicability-Domain-Guided Prioritization of Selective Human Carbonic Anhydrase I, II, IX, and XII Inhibitors.Pharmaceuticals (Basel)202642653817PubTator, text miningPubMed
Human Nasal and Bronchial Epithelium in Cystic Fibrosis: Differences in Expression of Airway pH Regulatory Proteins.Pediatr Pulmonol202642591023PubTator, text miningPubMed
Clone-By-Clone Therapy Guidance in Luminal Breast Cancer Via Spatial Proteomics and Patient-Derived Tumoroid.Mol Cell Proteomics202642586237PubTator, text miningPubMed
Hedgehog Signaling Regulates Hypoxia-Associated Metabolic Adaptation in Myeloid Leukemia In Vitro Cell Models.Int J Mol Sci202642511667PubTator, text miningPubMed
1-Aryl-6,7-Dimethoxy-3,4-Dihydroisoquinoline-2(1H)-Sulfonamides as hCA XII Selective Inhibitors: Experimental and Theoretical Studies to Interrogate the Isoform Selectivity.ChemMedChem202642493249PubTator, text miningPubMed
Carbonic anhydrase IX and XII.Enzymes202642486548PubTator, text miningPubMed

1 to 10 of 1,772

See all 1,772 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/771

GET https://conductscience.org/api/genes/v1/771/patents?page=2