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Gene · 780

DDR1: discoidin domain receptor tyrosine kinase 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. DDR1: discoidin domain receptor tyrosine kinase 1. Genes, record 780. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/780

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Gene

Symbol
DDR1
HGNC
Name
discoidin domain receptor tyrosine kinase 1
HGNC
NCBI Gene ID
780
NCBI Gene
HGNC ID
HGNC:2730
HGNC
Ensembl
ENSG00000204580
NCBI Gene
Aliases
CAK, CD167, DDR, EDDR1, HGK2, MCK10, NEP, NTRK4, PTK3, PTK3A, RTK6, TRKE
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q08345Epithelial discoidin domain-containing receptor 191334Ensembl, GeneID, HGNC

Source UniProt

Patents220

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-195171Q08345Espacenet
EP 4641201 A22025-10-294760Q08345Espacenet
JP 2025147176 A2025-10-064048Q08345Espacenet
JP 2025147176 A2025-10-064051Q08345Espacenet
JP 2025147176 A2025-10-064059Q08345Espacenet
JP 2025138725 A2025-09-252128Q08345Espacenet
JP 2025138725 A2025-09-252498Q08345Espacenet
JP 2025138725 A2025-09-252598Q08345Espacenet
JP 2025138725 A2025-09-252744Q08345Espacenet
JP 2025138725 A2025-09-252749Q08345Espacenet

1 to 10 of 220

See all 220 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,553

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleDDR1 papersNewest fiscal year
P30CA016672Cancer Center Support Grant132025
P30CA008748Cancer Center Support Grant122025
P30CA076292Moffitt Cancer Center Support Grant102025
I01BX002025Molecular Mechanisms of Kidney Fibrosis92025
P50CA058223SPORE in Breast Cancer82025
P30CA016086Cancer Center Support Grant72025
P30CA196521The Tisch Cancer Institute - Cancer Center Support Grant62025
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant52025
P40OD010440Caenorhabditis Genetics Center52025
I01BX002196lntegrin binding proteins and the kidney42025

1 to 10 of 1,553Source NIH's project files

See all 1,553 nih grants

Papers2,465

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Epigenome-Wide Association Study of Abdominal Aortic Aneurysm Identifies Central Role for Inflammatory Pathways.Circulation202642808173PubTator, text miningPubMed
Anlotinib enhances the sensitivity to docetaxel in lung cancer through inhibiting DDR1-mediated glycolytic pathway.Int J Biol Sci202642807855PubTator, text miningPubMed
DDR1 sustains ferroptosis resistance in pancreatic ductal adenocarcinoma via SLC40A1-mediated iron homeostasis.Oncogene202642778663PubTator, text miningPubMed
Inflammatory memory inactivates AMPK-stimulated DDR1 degradation to enable pancreatic cancer growth.Proc Natl Acad Sci U S A202642771502PubTator, text miningPubMed
Supermeres Containing the Discoidin Domain Receptor 1 Extracellular Domain Promote Collagen Alignment and Immune Exclusion in Microsatellite-Stable Colorectal Cancer.Cancer Res Commun202642673563PubTator, text miningPubMed
Type I collagen matrix signaling in cancer: receptor sensing and mechanotransduction.Cell Signal202642660397PubTator, text miningPubMed
Beyond Physical Proximity and "Tool Cells": The Missing Catalytic Evidence in the DDR1-STAT3 Axis of Keloids.Br J Dermatol202642640734PubTator, text miningPubMed
Reply to 'Beyond physical proximity and "tool cells": the missing catalytic evidence in the DDR1-STAT3 axis of keloids'.Br J Dermatol202642631507PubTator, text miningPubMed
HSP27 regulates force-coordinated DDR1 condensate disassembly and liquid-to-gel phase transition.Sci Adv202642599996PubTator, text miningPubMed
Integrating genomic structural equation modeling and experimental validation to unravel the genetic basis of male genital lichen sclerosus.Front Immunol202642553536PubTator, text miningPubMed

1 to 10 of 2,465

See all 2,465 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/780

GET https://conductscience.org/api/genes/v1/780/patents?page=2