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Gene · 79644

SRD5A3: steroid 5 alpha-reductase 3

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SRD5A3: steroid 5 alpha-reductase 3. Genes, record 79644. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/79644

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Gene

Symbol
SRD5A3
HGNC
Name
steroid 5 alpha-reductase 3
HGNC
NCBI Gene ID
79644
NCBI Gene
HGNC ID
HGNC:25812
HGNC
Ensembl
ENSG00000128039
NCBI Gene
Aliases
CDG1P, CDG1Q, FLJ13352, KRIZI, S5AR, S5AR 3, SRD5A2L, SRD5A2L1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9H8P0Polyprenal reductase3180Ensembl, GeneID, HGNC

Source UniProt

Patents43

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026067851 A2026-04-21238Q9H8P0Espacenet
JP 2026004568 A2026-01-1465595Q9H8P0Espacenet
EP 4650780 A22025-11-192324Q9H8P0Espacenet
JP 2025529142 A2025-09-044444Q9H8P0Espacenet
US 12371689 B22025-07-294444Q9H8P0Espacenet
JP 2025517970 A2025-06-122324Q9H8P0Espacenet
JP 2024507735 A2024-02-21142Q9H8P0Espacenet
JP 2023521663 A2023-05-25237Q9H8P0Espacenet
US 11446398 B22022-09-2084434Q9H8P0Espacenet
US 11400116 B22022-08-025053Q9H8P0Espacenet

1 to 10 of 43

See all 43 patents

Drugs2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ABIRATERONECHEMBL254328Steroid 5-alpha-reductase inhibitorINHIBITORChEMBL
DUTASTERIDECHEMBL1200969Steroid 5-alpha-reductase inhibitorINHIBITORChEMBL

Trials154

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07570979ABIRATERONEPHASE1ClinicalTrials.gov
NCT07553988ABIRATERONEPHASE2ClinicalTrials.gov
NCT07421804DUTASTERIDEClinicalTrials.gov
NCT07417449DUTASTERIDEClinicalTrials.gov
NCT07299292ABIRATERONEPHASE2ClinicalTrials.gov
NCT07237269ABIRATERONEPHASE2ClinicalTrials.gov
NCT07226986ABIRATERONEPHASE1/PHASE2ClinicalTrials.gov
NCT07190300ABIRATERONEPHASE1/PHASE2ClinicalTrials.gov
NCT07154914ABIRATERONEClinicalTrials.gov
NCT07140900ABIRATERONEPHASE1ClinicalTrials.gov

1 to 10 of 154

See all 154 trials

NIH grants242

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSRD5A3 papersNewest fiscal year
P30CA016056Roswell Park Cancer Center Support Grant72025
R01DK099551New Congenital Disorders of Glycosylation: Therapy and Models62025
P30ES013508Center of Excellence in Environmental Toxicology52025
P30CA016672Cancer Center Support Grant32025
P30CA068485Cancer Center Support Grant32025
P30DK020572Michigan Diabetes Research Center (MDRC)32025
P50CA097186The Pacific Northwest Prostate Cancer SPORE32025
P01CA163227Androgen Receptor Action in Castration Resistant Prostate Cancer22025
P30CA054174Mays Cancer Center at UT Health SA22025
P30CA093373Cancer Center Support Grant P3022025

1 to 10 of 242Source NIH's project files

See all 242 nih grants

Papers377

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
The lithium-magnesium-zinc axis under stress: regulation of N-glycosylation-linked proteostasis and Alzheimer's disease.Inflammopharmacology202642680959PubTator, text miningPubMed
Novel blood lncRNA biomarkers associated with clinical severity and specific cognitive dimensions in Alzheimer's disease.J Alzheimers Dis202642523149PubTator, text miningPubMed
Tissue-specific expression and regulation of congenital disorders of glycosylation genes: A GTEx-based in silico study.Mol Genet Metab Rep202642472049PubTator, text miningPubMed
SRD5A3-mediated aberrant N-glycosylation of SCARA5 promotes ferroptosis in lung adenocarcinoma.Oncogene202642401760PubTator, text miningPubMed
Endogenous oestrogens as neuroprotective modulators in the human retina: Evidence from transcriptomic profiling and aromatase inhibition.J Neuroendocrinol202641877439PubTator, text miningPubMed
Neuro-Ophthalmic Presentation of Steroid 5a-Reductase Type 3 Congenital Disorder of Glycosylation: A Case of Monozygotic Twins.Cureus202641769439PubTator, text miningPubMed
Extensive Hypoglycosylation of Serum N-Glycoproteins in SRD5A3 Deficiency.J Inherit Metab Dis202641732066PubTator, text miningPubMed
5α-Reductase Isoenzymes: From Neurosteroid Biosynthesis to Neuropsychiatric Outcomes.NeuroSci202641718149PubTator, text miningPubMed
Albumin as a glycoprotein biomarker in congenital disorders of glycosylation.Mol Genet Metab202641713138PubTator, text miningPubMed
Clinical, biochemical and genetic characterization of an Egyptian patient with SRD5A3-congenital glycosylation disorder.Ophthalmic Genet202641667393PubTator, text miningPubMed

1 to 10 of 377

See all 377 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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