Gene · 79644
SRD5A3: steroid 5 alpha-reductase 3
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. SRD5A3: steroid 5 alpha-reductase 3. Genes, record 79644. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/79644
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9H8P0 | Polyprenal reductase | 318 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents43
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026067851 A | 2026-04-21 | 238 | Q9H8P0 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 65595 | Q9H8P0 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 2324 | Q9H8P0 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 4444 | Q9H8P0 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 4444 | Q9H8P0 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 2324 | Q9H8P0 | Espacenet |
| JP 2024507735 A | 2024-02-21 | 142 | Q9H8P0 | Espacenet |
| JP 2023521663 A | 2023-05-25 | 237 | Q9H8P0 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 84434 | Q9H8P0 | Espacenet |
| US 11400116 B2 | 2022-08-02 | 5053 | Q9H8P0 | Espacenet |
1 to 10 of 43
See all 43 patentsDrugs2
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
Trials154
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07570979 | ABIRATERONE | PHASE1 | ClinicalTrials.gov | |
| NCT07553988 | ABIRATERONE | PHASE2 | ClinicalTrials.gov | |
| NCT07421804 | DUTASTERIDE | ClinicalTrials.gov | ||
| NCT07417449 | DUTASTERIDE | ClinicalTrials.gov | ||
| NCT07299292 | ABIRATERONE | PHASE2 | ClinicalTrials.gov | |
| NCT07237269 | ABIRATERONE | PHASE2 | ClinicalTrials.gov | |
| NCT07226986 | ABIRATERONE | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT07190300 | ABIRATERONE | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT07154914 | ABIRATERONE | ClinicalTrials.gov | ||
| NCT07140900 | ABIRATERONE | PHASE1 | ClinicalTrials.gov |
1 to 10 of 154
See all 154 trialsNIH grants242
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | SRD5A3 papers | Newest fiscal year |
|---|---|---|---|
| P30CA016056 | Roswell Park Cancer Center Support Grant | 7 | 2025 |
| R01DK099551 | New Congenital Disorders of Glycosylation: Therapy and Models | 6 | 2025 |
| P30ES013508 | Center of Excellence in Environmental Toxicology | 5 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 3 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 3 | 2025 |
| P30DK020572 | Michigan Diabetes Research Center (MDRC) | 3 | 2025 |
| P50CA097186 | The Pacific Northwest Prostate Cancer SPORE | 3 | 2025 |
| P01CA163227 | Androgen Receptor Action in Castration Resistant Prostate Cancer | 2 | 2025 |
| P30CA054174 | Mays Cancer Center at UT Health SA | 2 | 2025 |
| P30CA093373 | Cancer Center Support Grant P30 | 2 | 2025 |
1 to 10 of 242Source NIH's project files
See all 242 nih grantsPapers377
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| The lithium-magnesium-zinc axis under stress: regulation of N-glycosylation-linked proteostasis and Alzheimer's disease. | Inflammopharmacology | 2026 | 42680959 | PubTator, text mining | PubMed |
| Novel blood lncRNA biomarkers associated with clinical severity and specific cognitive dimensions in Alzheimer's disease. | J Alzheimers Dis | 2026 | 42523149 | PubTator, text mining | PubMed |
| Tissue-specific expression and regulation of congenital disorders of glycosylation genes: A GTEx-based in silico study. | Mol Genet Metab Rep | 2026 | 42472049 | PubTator, text mining | PubMed |
| SRD5A3-mediated aberrant N-glycosylation of SCARA5 promotes ferroptosis in lung adenocarcinoma. | Oncogene | 2026 | 42401760 | PubTator, text mining | PubMed |
| Endogenous oestrogens as neuroprotective modulators in the human retina: Evidence from transcriptomic profiling and aromatase inhibition. | J Neuroendocrinol | 2026 | 41877439 | PubTator, text mining | PubMed |
| Neuro-Ophthalmic Presentation of Steroid 5a-Reductase Type 3 Congenital Disorder of Glycosylation: A Case of Monozygotic Twins. | Cureus | 2026 | 41769439 | PubTator, text mining | PubMed |
| Extensive Hypoglycosylation of Serum N-Glycoproteins in SRD5A3 Deficiency. | J Inherit Metab Dis | 2026 | 41732066 | PubTator, text mining | PubMed |
| 5α-Reductase Isoenzymes: From Neurosteroid Biosynthesis to Neuropsychiatric Outcomes. | NeuroSci | 2026 | 41718149 | PubTator, text mining | PubMed |
| Albumin as a glycoprotein biomarker in congenital disorders of glycosylation. | Mol Genet Metab | 2026 | 41713138 | PubTator, text mining | PubMed |
| Clinical, biochemical and genetic characterization of an Egyptian patient with SRD5A3-congenital glycosylation disorder. | Ophthalmic Genet | 2026 | 41667393 | PubTator, text mining | PubMed |
1 to 10 of 377
See all 377 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/79644
GET https://conductscience.org/api/genes/v1/79644/patents?page=2