Gene · 80198
MUS81: MUS81 structure-specific endonuclease subunit
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. MUS81: MUS81 structure-specific endonuclease subunit. Genes, record 80198. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/80198
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q96NY9 | Structure-specific endonuclease subunit MUS81 | 551 | 15 | Ensembl, GeneID, HGNC |
Source UniProt
Patents31
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4464338 A2 | 2024-11-20 | 192 | Q96NY9 | Espacenet |
| JP 2024123008 A | 2024-09-10 | 7122 | Q96NY9 | Espacenet |
| JP 2024123008 A | 2024-09-10 | 7123 | Q96NY9 | Espacenet |
| JP 2024504002 A | 2024-01-30 | 75 | Q96NY9 | Espacenet |
| JP 2024502755 A | 2024-01-23 | 74 | Q96NY9 | Espacenet |
| JP 2024500874 A | 2024-01-10 | 75 | Q96NY9 | Espacenet |
| JP 2024500877 A | 2024-01-10 | 75 | Q96NY9 | Espacenet |
| US 11680268 B2 | 2023-06-20 | 192 | Q96NY9 | Espacenet |
| US 11597924 B2 | 2023-03-07 | 30 | Q96NY9 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 53483 | Q96NY9 | Espacenet |
1 to 10 of 31
See all 31 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,126
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | MUS81 papers | Newest fiscal year |
|---|---|---|---|
| P01CA092584 | Structural Cell Biology of DNA Repair Machines | 17 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 14 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 14 | 2025 |
| R01GM058015 | Recombinational Mechanisms of DNA Repair | 13 | 2025 |
| R01CA187052 | Studying the mechanisms underlying the protection of common fragile sites and structure-prone DNA sequences | 10 | 2025 |
| ZIABC006150 | DNA Repair, Cell Cycle Checkpoints and Apoptosis as Targets for Anticancer Drugs | 10 | 2025 |
| ZIAAG000741 | Roles Of DNA Helicases In Pathways Required For Maintenance Of Genomic Stability | 8 | 2025 |
| P30CA086862 | Cancer Center Support Grant | 7 | 2025 |
| R01CA232425 | The Role of Human RAD52 Protein in Genome Stability | 6 | 2025 |
| R01GM072551 | Synaptonemal Complex Assembly and Function in Meiosis | 6 | 2025 |
1 to 10 of 1,126Source NIH's project files
See all 1,126 nih grantsPapers1,460
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Correction: MUS81 participates in the progression of serous ovarian cancer associated with dysfunctional DNA repair system. | Front Oncol | 2026 | 42757248 | PubTator, text mining | PubMed |
| Scutellarin as a specific GEN1 inhibitor synergizes with olaparib to induce synthetic lethality in human tumor cells. | Bioorg Chem | 2026 | 42632200 | PubTator, text mining | PubMed |
| CHK2 regulates MUS81-dependent DSBs in response to replication stress and BRCA2 deficiency. | Nucleic Acids Res | 2026 | 42598853 | PubTator, text mining | PubMed |
| CRISPR Screening Identifies SMARCAL1 and MRN as Modulators of WRN Dependency in MSI-H Colorectal Cancer. | Cancer Res | 2026 | 42484294 | PubTator, text mining | PubMed |
| Author Correction: Epitranscriptomic RNA editing resolves Mus81 DNA repair tradeoffs in heat tolerance and meiosis. | Nat Commun | 2026 | 42425981 | PubTator, text mining | PubMed |
| CIP2A recruits SLX4-MUS81-XPF in mitosis and protects against replication stress. | EMBO Rep | 2026 | 42192029 | PubTator, text mining | PubMed |
| Phosphorylation by CDK1 switches the function of the human SLX4 SAP domain from DNA binding to MUS81 binding. | Nucleic Acids Res | 2026 | 42130070 | PubTator, text mining | PubMed |
| Genome-Scale CRISPR Screens Reveal DNA Repair Dependencies That Sensitize Hepatocellular Carcinoma to Oxaliplatin. | Cancers (Basel) | 2026 | 42122158 | PubTator, text mining | PubMed |
| COSA-1-SLX-4 interaction directly links crossover designation with Holliday junction resolution. | Sci Adv | 2026 | 42030394 | PubTator, text mining | PubMed |
| Distinct mechanisms of replication stress induced by oncogenic RAS and cyclin E1 converge on R-loop-dependent fork reversal. | Nat Commun | 2026 | 41932903 | PubTator, text mining | PubMed |
1 to 10 of 1,460
See all 1,460 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/80198
GET https://conductscience.org/api/genes/v1/80198/patents?page=2