ConductScience.org, home

Gene · 80198

MUS81: MUS81 structure-specific endonuclease subunit

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. MUS81: MUS81 structure-specific endonuclease subunit. Genes, record 80198. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/80198

On this page

Gene

Symbol
MUS81
HGNC
Name
MUS81 structure-specific endonuclease subunit
HGNC
NCBI Gene ID
80198
NCBI Gene
HGNC ID
HGNC:29814
HGNC
Ensembl
ENSG00000172732
NCBI Gene
Aliases
FLJ44872, SLX3
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q96NY9Structure-specific endonuclease subunit MUS8155115Ensembl, GeneID, HGNC

Source UniProt

Patents31

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4464338 A22024-11-20192Q96NY9Espacenet
JP 2024123008 A2024-09-107122Q96NY9Espacenet
JP 2024123008 A2024-09-107123Q96NY9Espacenet
JP 2024504002 A2024-01-3075Q96NY9Espacenet
JP 2024502755 A2024-01-2374Q96NY9Espacenet
JP 2024500874 A2024-01-1075Q96NY9Espacenet
JP 2024500877 A2024-01-1075Q96NY9Espacenet
US 11680268 B22023-06-20192Q96NY9Espacenet
US 11597924 B22023-03-0730Q96NY9Espacenet
US 11446398 B22022-09-2053483Q96NY9Espacenet

1 to 10 of 31

See all 31 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,126

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMUS81 papersNewest fiscal year
P01CA092584Structural Cell Biology of DNA Repair Machines172025
P30CA008748Cancer Center Support Grant142025
P30CA016672Cancer Center Support Grant142025
R01GM058015Recombinational Mechanisms of DNA Repair132025
R01CA187052Studying the mechanisms underlying the protection of common fragile sites and structure-prone DNA sequences102025
ZIABC006150DNA Repair, Cell Cycle Checkpoints and Apoptosis as Targets for Anticancer Drugs102025
ZIAAG000741Roles Of DNA Helicases In Pathways Required For Maintenance Of Genomic Stability82025
P30CA086862Cancer Center Support Grant72025
R01CA232425The Role of Human RAD52 Protein in Genome Stability62025
R01GM072551Synaptonemal Complex Assembly and Function in Meiosis62025

1 to 10 of 1,126Source NIH's project files

See all 1,126 nih grants

Papers1,460

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Correction: MUS81 participates in the progression of serous ovarian cancer associated with dysfunctional DNA repair system.Front Oncol202642757248PubTator, text miningPubMed
Scutellarin as a specific GEN1 inhibitor synergizes with olaparib to induce synthetic lethality in human tumor cells.Bioorg Chem202642632200PubTator, text miningPubMed
CHK2 regulates MUS81-dependent DSBs in response to replication stress and BRCA2 deficiency.Nucleic Acids Res202642598853PubTator, text miningPubMed
CRISPR Screening Identifies SMARCAL1 and MRN as Modulators of WRN Dependency in MSI-H Colorectal Cancer.Cancer Res202642484294PubTator, text miningPubMed
Author Correction: Epitranscriptomic RNA editing resolves Mus81 DNA repair tradeoffs in heat tolerance and meiosis.Nat Commun202642425981PubTator, text miningPubMed
CIP2A recruits SLX4-MUS81-XPF in mitosis and protects against replication stress.EMBO Rep202642192029PubTator, text miningPubMed
Phosphorylation by CDK1 switches the function of the human SLX4 SAP domain from DNA binding to MUS81 binding.Nucleic Acids Res202642130070PubTator, text miningPubMed
Genome-Scale CRISPR Screens Reveal DNA Repair Dependencies That Sensitize Hepatocellular Carcinoma to Oxaliplatin.Cancers (Basel)202642122158PubTator, text miningPubMed
COSA-1-SLX-4 interaction directly links crossover designation with Holliday junction resolution.Sci Adv202642030394PubTator, text miningPubMed
Distinct mechanisms of replication stress induced by oncogenic RAS and cyclin E1 converge on R-loop-dependent fork reversal.Nat Commun202641932903PubTator, text miningPubMed

1 to 10 of 1,460

See all 1,460 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/80198

GET https://conductscience.org/api/genes/v1/80198/patents?page=2