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Gene · 8174

MADCAM1: mucosal vascular addressin cell adhesion molecule 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. MADCAM1: mucosal vascular addressin cell adhesion molecule 1. Genes, record 8174. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8174

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Gene

Symbol
MADCAM1
HGNC
Name
mucosal vascular addressin cell adhesion molecule 1
HGNC
NCBI Gene ID
8174
NCBI Gene
HGNC ID
HGNC:6765
HGNC
Ensembl
ENSG00000099866
NCBI Gene
Aliases
MACAM1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q13477Mucosal addressin cell adhesion molecule 13827Ensembl, GeneID, HGNC

Source UniProt

Patents33

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
WO 2026019692 A22026-01-22581Q13477Espacenet
EP 4650780 A22025-11-19272Q13477Espacenet
JP 2025529142 A2025-09-042512Q13477Espacenet
US 12371689 B22025-07-292512Q13477Espacenet
JP 2025517970 A2025-06-12272Q13477Espacenet
JP 2024037932 A2024-03-195Q13477Espacenet
JP 2023535556 A2023-08-185Q13477Espacenet
US 11639390 B22023-05-025Q13477Espacenet
KR 1020230038728 A2023-03-215Q13477Espacenet
US 11446398 B22022-09-2053350Q13477Espacenet

1 to 10 of 33

See all 33 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
ONTAMALIMABCHEMBL2109511Mucosal addressin cell adhesion molecule-1 inhibitorINHIBITOR

Source ChEMBL

Trials14

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07052682ONTAMALIMABPHASE12025-08-19ClinicalTrials.gov
NCT03627091ONTAMALIMABPHASE32022-03-31ClinicalTrials.gov
NCT03566823ONTAMALIMABPHASE32021-05-11ClinicalTrials.gov
NCT03559517ONTAMALIMABPHASE32021-04-29ClinicalTrials.gov
NCT03290781ONTAMALIMABPHASE32022-01-14ClinicalTrials.gov
NCT03283085ONTAMALIMABPHASE32024-06-21ClinicalTrials.gov
NCT03259334ONTAMALIMABPHASE32021-05-07ClinicalTrials.gov
NCT03259308ONTAMALIMABPHASE32021-04-26ClinicalTrials.gov
NCT01771809ONTAMALIMABPHASE22019-04-18ClinicalTrials.gov
NCT01620255ONTAMALIMABPHASE22017-03-27ClinicalTrials.gov

1 to 10 of 14

See all 14 trials

NIH grants1,169

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMADCAM1 papersNewest fiscal year
ZIAAI000887Role of HIV Envelope Proteins In Viral Replication and HIV Pathogenesis112025
P51OD011104Tulane National Primate Research Center82025
P30CA008748Cancer Center Support Grant72025
P30CA044579University of Virginia Cancer Center Support Grant72025
P30DK120515San Diego Digestive Diseases Research Center62025
U24AI126683Nonhuman Primate Reagent Resource62025
T32AI007496Interdisciplinary Training Program in Immunology52025
P01CA039542Cellular and Molecular Studies of Bone Marrow Transplant42025
P30DK034854Integrated Epithelial and Muscosal Biology42025
P30DK042086Center for Interdisciplinary Study of Inflammatory Intestinal DIsorders (C-IID)42025

1 to 10 of 1,169Source NIH's project files

See all 1,169 nih grants

Papers1,829

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Tumor Vascular Features and Colorectal Cancer-Specific Mortality.JAMA Netw Open202642804694PubTator, text miningPubMed
Immunohistochemical Detection, In Situ Distribution, and Comparison of Tuft Cells and Other Selected Components of Mucosal Immunity in Nasal Turbinates of Piglets Challenged with Rotavirus from Sows Fed Vitamin A-Deficient Diets with or Without Vitamin A Supplementation.
Vet Sci202642798020PubTator, text miningPubMed
Kindlin-3 is a Regulator of Force-Regulated Activation of Integrin α4β7 by CCL25 During Lymphocyte Adhesion.Cell Mol Bioeng202642729615PubTator, text miningPubMed
MADCAM1 Gene Variants as Potential Pharmacogenomics Markers for Vedolizumab Response in Crohn's Disease Bio-Naïve Patients.Diagnostics (Basel)202642650926PubTator, text miningPubMed
Integrin α4β7: Pathogenic Roles in Metabolic and Inflammatory Diseases and Translational Therapeutics.J Inflamm Res202642572795PubTator, text miningPubMed
Circulating memory-phenotype CD4+ T cells rapidly accumulate in the ischemic gut to exacerbate tissue injury in an innate manner.Cell Rep202642531132PubTator, text miningPubMed
Subclinical cholestasis is a hallmark of gut dysbiosis causing resistance to cancer immunotherapy.Cancer Cell202642526445PubTator, text miningPubMed
A bioinformatics pipeline for identifying clinically relevant immune and adhesion biomarkers in thyroid risk stratification.Front Mol Biosci202642416487PubTator, text miningPubMed
Inflammatory bowel disease and primary sclerosing cholangitis: immunological links and clinical outlook.Expert Rev Clin Immunol202642017751PubTator, text miningPubMed
Inflammatory bowel disease and extracellular matrix: when victim becomes double agent.Inflamm Res202641843067PubTator, text miningPubMed

1 to 10 of 1,829

See all 1,829 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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