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Gene · 83667

SESN2: sestrin 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SESN2: sestrin 2. Genes, record 83667. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/83667

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Gene

Symbol
SESN2
HGNC
Name
sestrin 2
HGNC
NCBI Gene ID
83667
NCBI Gene
HGNC ID
HGNC:20746
HGNC
Ensembl
ENSG00000130766
NCBI Gene
Aliases
DKFZp761M0212, HI95, SES2, SEST2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P58004Sestrin-24807Ensembl, GeneID, HGNC

Source UniProt

Patents27

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-191428P58004Espacenet
JP 2025517970 A2025-06-121428P58004Espacenet
JP 2025503500 A2025-02-044P58004Espacenet
KR 1020240144153 A2024-10-024P58004Espacenet
US 11564998 B22023-01-314827P58004Espacenet
US 11446398 B22022-09-2078290P58004Espacenet
JP 2022524081 A2022-04-27181261P58004Espacenet
US 10463751 B22019-11-054827P58004Espacenet
US 10168338 B22019-01-012P58004Espacenet
WO 2018100410 A12018-06-072P58004Espacenet

1 to 10 of 27

See all 27 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants913

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSESN2 papersNewest fiscal year
P30DK020572Michigan Diabetes Research Center (MDRC)122025
P30AG024824Claude D. Pepper Older Americans Independence Center at the University of Michigan (UM Pepper Center)112025
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-2028102025
P30DK089503Michigan Nutrition Obesity Research Center92025
P30CA008748Cancer Center Support Grant82025
P30CA014051Cancer Center Support (Core) Grant62025
P30CA016672Cancer Center Support Grant62025
R01CA090764PI3K/PTEN/Akt signaling and the genesis of cancer52025
T32AG000114Career Training in the Biology of Aging52025
P30CA014599Cancer Center Support Grant42025

1 to 10 of 913Source NIH's project files

See all 913 nih grants

Papers1,838

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
An immune-adaptive 3D-printed scaffold promotes endogenous osteogenesis by engineered macrophage capture traps.Biomaterials202742607641PubTator, text miningPubMed
Evaluation of Clusterin, Sestrin-2, Oxidative Stress, and Inflammatory Indices in Patients with Alzheimer's Disease Dementia.Brain Sci202642793402PubTator, text miningPubMed
Correlation analysis of serum FGF9, Sestrin2 and HBDH with the severity of sepsis.J Med Biochem202642780906PubTator, text miningPubMed
CBX3 aggravates nucleus pulposus cell apoptosis and extracellular matrix degradation in vitro via repressing SESN2-mediated mitophagy in an H3K9me3-dependent manner.Mol Biol Rep202642776360PubTator, text miningPubMed
D-amino acid prodrug DLMEH activates mTORC1 via Sestrin2 to restore muscle protein synthesis in sarcopenia.Mol Ther202642723280PubTator, text miningPubMed
CD84 expression stratifies venetoclax response and reveals a targetable vulnerability in resistant acute myeloid leukemia.Exp Hematol Oncol202642706583PubTator, text miningPubMed
Age and sex modify the association between plasma Sestrin2 and bone mineral density: a cross-sectional study.JBMR Plus202642689222PubTator, text miningPubMed
Evaluation of the Nrf2-Keap1 and Sestrin-2 Pathways in the Serum of Patients with Hidradenitis Suppurativa.Medicina (Kaunas)202642654508PubTator, text miningPubMed
SIRT2 deacylase modulators control B cell metabolic reprogramming in EBV infection and mitogenic activation.Proc Natl Acad Sci U S A202642636358PubTator, text miningPubMed
CqSESN2 suppresses WSSV infection via the CqNrf2 antioxidant pathway in Cherax quadricarinatus.Fish Shellfish Immunol202642628590PubTator, text miningPubMed

1 to 10 of 1,838

See all 1,838 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/83667

GET https://conductscience.org/api/genes/v1/83667/patents?page=2