Gene · 83667
SESN2: sestrin 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. SESN2: sestrin 2. Genes, record 83667. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/83667
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P58004 | Sestrin-2 | 480 | 7 | Ensembl, GeneID, HGNC |
Source UniProt
Patents27
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 1428 | P58004 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 1428 | P58004 | Espacenet |
| JP 2025503500 A | 2025-02-04 | 4 | P58004 | Espacenet |
| KR 1020240144153 A | 2024-10-02 | 4 | P58004 | Espacenet |
| US 11564998 B2 | 2023-01-31 | 4827 | P58004 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 78290 | P58004 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 181261 | P58004 | Espacenet |
| US 10463751 B2 | 2019-11-05 | 4827 | P58004 | Espacenet |
| US 10168338 B2 | 2019-01-01 | 2 | P58004 | Espacenet |
| WO 2018100410 A1 | 2018-06-07 | 2 | P58004 | Espacenet |
1 to 10 of 27
See all 27 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants913
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | SESN2 papers | Newest fiscal year |
|---|---|---|---|
| P30DK020572 | Michigan Diabetes Research Center (MDRC) | 12 | 2025 |
| P30AG024824 | Claude D. Pepper Older Americans Independence Center at the University of Michigan (UM Pepper Center) | 11 | 2025 |
| P30CA046592 | University of Michigan Rogel Cancer Center Support Grant 2023-2028 | 10 | 2025 |
| P30DK089503 | Michigan Nutrition Obesity Research Center | 9 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 8 | 2025 |
| P30CA014051 | Cancer Center Support (Core) Grant | 6 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 6 | 2025 |
| R01CA090764 | PI3K/PTEN/Akt signaling and the genesis of cancer | 5 | 2025 |
| T32AG000114 | Career Training in the Biology of Aging | 5 | 2025 |
| P30CA014599 | Cancer Center Support Grant | 4 | 2025 |
1 to 10 of 913Source NIH's project files
See all 913 nih grantsPapers1,838
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| An immune-adaptive 3D-printed scaffold promotes endogenous osteogenesis by engineered macrophage capture traps. | Biomaterials | 2027 | 42607641 | PubTator, text mining | PubMed |
| Evaluation of Clusterin, Sestrin-2, Oxidative Stress, and Inflammatory Indices in Patients with Alzheimer's Disease Dementia. | Brain Sci | 2026 | 42793402 | PubTator, text mining | PubMed |
| Correlation analysis of serum FGF9, Sestrin2 and HBDH with the severity of sepsis. | J Med Biochem | 2026 | 42780906 | PubTator, text mining | PubMed |
| CBX3 aggravates nucleus pulposus cell apoptosis and extracellular matrix degradation in vitro via repressing SESN2-mediated mitophagy in an H3K9me3-dependent manner. | Mol Biol Rep | 2026 | 42776360 | PubTator, text mining | PubMed |
| D-amino acid prodrug DLMEH activates mTORC1 via Sestrin2 to restore muscle protein synthesis in sarcopenia. | Mol Ther | 2026 | 42723280 | PubTator, text mining | PubMed |
| CD84 expression stratifies venetoclax response and reveals a targetable vulnerability in resistant acute myeloid leukemia. | Exp Hematol Oncol | 2026 | 42706583 | PubTator, text mining | PubMed |
| Age and sex modify the association between plasma Sestrin2 and bone mineral density: a cross-sectional study. | JBMR Plus | 2026 | 42689222 | PubTator, text mining | PubMed |
| Evaluation of the Nrf2-Keap1 and Sestrin-2 Pathways in the Serum of Patients with Hidradenitis Suppurativa. | Medicina (Kaunas) | 2026 | 42654508 | PubTator, text mining | PubMed |
| SIRT2 deacylase modulators control B cell metabolic reprogramming in EBV infection and mitogenic activation. | Proc Natl Acad Sci U S A | 2026 | 42636358 | PubTator, text mining | PubMed |
| CqSESN2 suppresses WSSV infection via the CqNrf2 antioxidant pathway in Cherax quadricarinatus. | Fish Shellfish Immunol | 2026 | 42628590 | PubTator, text mining | PubMed |
1 to 10 of 1,838
See all 1,838 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/83667
GET https://conductscience.org/api/genes/v1/83667/patents?page=2