ConductScience.org, home

Gene · 85301

COL27A1: collagen type XXVII alpha 1 chain

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. COL27A1: collagen type XXVII alpha 1 chain. Genes, record 85301. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/85301

On this page

Gene

Symbol
COL27A1
HGNC
Name
collagen type XXVII alpha 1 chain
HGNC
NCBI Gene ID
85301
NCBI Gene
HGNC ID
HGNC:22986
HGNC
Ensembl
ENSG00000196739
NCBI Gene
Aliases
FLJ11895, KIAA1870, MGC11337, STLS
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q8IZC6Collagen alpha-1(XXVII) chain1,8600Ensembl, GeneID, HGNC

Source UniProt

Patents29

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4641201 A22025-10-297182Q8IZC6Espacenet
JP 2025147176 A2025-10-063278Q8IZC6Espacenet
JP 2025529142 A2025-09-045948Q8IZC6Espacenet
US 12371689 B22025-07-295948Q8IZC6Espacenet
JP 2025517969 A2025-06-127182Q8IZC6Espacenet
JP 2025028160 A2025-02-283278Q8IZC6Espacenet
KR 1020250010750 A2025-01-213278Q8IZC6Espacenet
JP 2024109657 A2024-08-143285Q8IZC6Espacenet
US 11446398 B22022-09-2019175Q8IZC6Espacenet
JP 2022524081 A2022-04-27122146Q8IZC6Espacenet

1 to 10 of 29

See all 29 patents

Drugs2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
COLLAGENASE CLOSTRIDIUM HISTOLYTICUMCHEMBL2108709Collagen hydrolytic enzymeHYDROLYTIC ENZYMEChEMBL
OCRIPLASMINCHEMBL2095222Collagen hydrolytic enzymeHYDROLYTIC ENZYMEChEMBL

Trials66

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06169319COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE2ClinicalTrials.gov
NCT06151197COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE3ClinicalTrials.gov
NCT06065436COLLAGENASE CLOSTRIDIUM HISTOLYTICUMClinicalTrials.gov
NCT05646602COLLAGENASE CLOSTRIDIUM HISTOLYTICUMClinicalTrials.gov
NCT05254457COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE3ClinicalTrials.gov
NCT05152173COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE2ClinicalTrials.gov
NCT04874870COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE3ClinicalTrials.gov
NCT04680156COLLAGENASE CLOSTRIDIUM HISTOLYTICUMClinicalTrials.gov
NCT04496167COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE22023-09-13ClinicalTrials.gov
NCT04236635COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE22022-04-12ClinicalTrials.gov

1 to 10 of 66

See all 66 trials

NIH grants383

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCOL27A1 papersNewest fiscal year
P20GM103408Idaho INBRE Program32025
P30CA016087Cancer Center Support Grant32025
P30CA014051Cancer Center Support (Core) Grant22025
P30CA016672Cancer Center Support Grant22025
R01HG012869Empowering gene discovery and accelerating clinical translation for admixed populations22025
R24HD000836Laboratory of Developmental Biology22025
R25MH077823Research Education for Future Physician-Scientists in Child Psychiatry22025
R35NS105078STRUCTURAL VARIATION IN NEUROLOGICAL DISEASE22025
T32GM136554The Clinical Translational Research Certificate of Added Qualification Program22025
T32GM139534Genetics & Genomics Training Program22025

1 to 10 of 383Source NIH's project files

See all 383 nih grants

Papers402

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Whole Genome Sequencing of Discordant Monozygotic Twins Reveals Regulatory Variants Associated With Nonsyndromic Orofacial Clefts.Hum Mutat202642787608PubTator, text miningPubMed
Transcriptomic profiling of collagen gene expression in lung fibroblasts from patients with idiopathic pulmonary fibrosis.Sarcoidosis Vasc Diffuse Lung Dis202642329017PubTator, text miningPubMed
A Scoping Review on Genetic Mutations and Single-Nucleotide Polymorphisms Associated with Pectus Excavatum.J Multidiscip Healthc202641890568PubTator, text miningPubMed
3D pentaculture model unveils malignant cell-driven macrophage polarization in high-grade serous ovarian cancer.Nat Commun202641881987PubTator, text miningPubMed
Exploring the clinical and genetic spectrum of Steel syndrome: two case reports and review of the literature.Front Med (Lausanne)202641788698PubTator, text miningPubMed
Cis-regulatory evolution reveals sensory trade-offs as a genetic basis for temporal niche evolution in tapirs.Sci Adv202641779860PubTator, text miningPubMed
Redox-Related Genetic and Biological Ageing Signals in Rapid Pain Progression of Knee Osteoarthritis: A Hypothesis-Generating Analysis in the Osteoarthritis Initiative.Antioxidants (Basel)202641750646PubTator, text miningPubMed
Injury-Induced Epithelial Spp1 Engages Cd44 to Promote Neutrophil Recruitment and Exacerbate Acute Kidney Injury.J Inflamm Res202641737246PubTator, text miningPubMed
PGVDA: a pathway-aggregated genetic dosage framework for interpretable disease classification using machine learning.Brief Bioinform202641632594PubTator, text miningPubMed
Exploring socio-economic, biochemical, and genetic factors influencing thyroid status in Indian school-going adolescents.J Hum Genet202641249461PubTator, text miningPubMed

1 to 10 of 402

See all 402 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/85301

GET https://conductscience.org/api/genes/v1/85301/patents?page=2