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Gene · 8553

BHLHE40: basic helix-loop-helix family member e40

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. BHLHE40: basic helix-loop-helix family member e40. Genes, record 8553. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8553

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Gene

Symbol
BHLHE40
HGNC
Name
basic helix-loop-helix family member e40
HGNC
NCBI Gene ID
8553
NCBI Gene
HGNC ID
HGNC:1046
HGNC
Ensembl
ENSG00000134107
NCBI Gene
Aliases
BHLHB2, Clast5, DEC1, HLHB2, SHARP-2, SHARP2, STRA13, Stra14
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O14503Class E basic helix-loop-helix protein 404120Ensembl, GeneID, HGNC

Source UniProt

Patents74

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
WO 2026180466 A12026-09-032O14503Espacenet
WO 2026034527 A2026-02-123O14503Espacenet
JP 2026004568 A2026-01-1438627O14503Espacenet
EP 4650780 A22025-11-191584O14503Espacenet
JP 2025147176 A2025-10-0614801O14503Espacenet
JP 2025517970 A2025-06-121584O14503Espacenet
JP 2025062604 A2025-04-148334O14503Espacenet
JP 2025032204 A2025-03-1125187O14503Espacenet
JP 2025028160 A2025-02-2814801O14503Espacenet
KR 1020250010750 A2025-01-2114801O14503Espacenet

1 to 10 of 74

See all 74 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,378

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleBHLHE40 papersNewest fiscal year
P30CA016672Cancer Center Support Grant82025
P30CA008748Cancer Center Support Grant72025
P30CA016520Abramson Cancer Center Support Grant52025
P01AI039671Costimulatory Mechanisms of Autoimmunity32025
P01CA214278Enhancing Chimeric Antigen Receptor T Cell Therapies for HematologicMalignancies: Beyond CART 1932025
P30CA010815Consolidated Basic Cancer Research Program32025
P30CA014051Cancer Center Support (Core) Grant32025
P30CA016086Cancer Center Support Grant32025
P30CA016087Cancer Center Support Grant32025
R01AI147394Host cellular network governing the development of post SARS-CoV-2 tissue sequelae32025

1 to 10 of 1,378Source NIH's project files

See all 1,378 nih grants

Papers1,588

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
When Neutrophils Do Not Die: Senescence as a New Axis of Tumor Immunosuppression.Cancer Discov202642817716PubTator, text miningPubMed
Clock-Related Genes Mark a Developmental Cortical Maturation Program Associated with Stage-Resolved Responses to Prenatal Immune Activation.Genes (Basel)202642793001PubTator, text miningPubMed
Trimester-specific associations of methyl-donor nutrients and prenatal dietary patterns with adolescent blood leukocyte circadian gene DNA methylation.J Dev Orig Health Dis202642788273PubTator, text miningPubMed
Single-cell RNA-seq analysis revealed that BHLHE40 and its binding protein THBS1 are involved in diabetic corneal epitheliopathy.Exp Eye Res202642697405PubTator, text miningPubMed
BHLHE40 and ChREBP associate with hepatic enhancer clusters containing PPARα, RXRα, and HNF4 nuclear receptors.Endocrinology202642626966PubTator, text miningPubMed
Modulation of neuronal excitability and plasticity by BHLHE41 conveys lithium non-responsiveness.Mol Psychiatry202642613416PubTator, text miningPubMed
Integrative Transcriptomics Links Dapagliflozin-Opposed Macrophage Programs to BHLHE40-Associated Regulation and NFKB1-Associated Signaling in HFpEF.OMICS202642605950PubTator, text miningPubMed
A machine learning-derived and functionally validated circadian rhythm signature predicts clinical outcomes and in silico drug sensitivity in colorectal cancer.Transl Oncol202642520477PubTator, text miningPubMed
Intratumoral Hypoxia Triggers Mitochondrial BHLHE40 ROS Sensing Pathway to Promote Radioresistance in Triple-Negative Breast Cancer.Adv Sci (Weinh)202642505118PubTator, text miningPubMed
BHLHE40/DEC1 programs epidermal Langerhans cell identity.J Invest Dermatol202642492657PubTator, text miningPubMed

1 to 10 of 1,588

See all 1,588 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/8553

GET https://conductscience.org/api/genes/v1/8553/patents?page=2