Gene · 8553
BHLHE40: basic helix-loop-helix family member e40
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. BHLHE40: basic helix-loop-helix family member e40. Genes, record 8553. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8553
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O14503 | Class E basic helix-loop-helix protein 40 | 412 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents74
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| WO 2026180466 A1 | 2026-09-03 | 2 | O14503 | Espacenet |
| WO 2026034527 A | 2026-02-12 | 3 | O14503 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 38627 | O14503 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 1584 | O14503 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 14801 | O14503 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 1584 | O14503 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 8334 | O14503 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 25187 | O14503 | Espacenet |
| JP 2025028160 A | 2025-02-28 | 14801 | O14503 | Espacenet |
| KR 1020250010750 A | 2025-01-21 | 14801 | O14503 | Espacenet |
1 to 10 of 74
See all 74 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,378
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | BHLHE40 papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 8 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 7 | 2025 |
| P30CA016520 | Abramson Cancer Center Support Grant | 5 | 2025 |
| P01AI039671 | Costimulatory Mechanisms of Autoimmunity | 3 | 2025 |
| P01CA214278 | Enhancing Chimeric Antigen Receptor T Cell Therapies for HematologicMalignancies: Beyond CART 19 | 3 | 2025 |
| P30CA010815 | Consolidated Basic Cancer Research Program | 3 | 2025 |
| P30CA014051 | Cancer Center Support (Core) Grant | 3 | 2025 |
| P30CA016086 | Cancer Center Support Grant | 3 | 2025 |
| P30CA016087 | Cancer Center Support Grant | 3 | 2025 |
| R01AI147394 | Host cellular network governing the development of post SARS-CoV-2 tissue sequelae | 3 | 2025 |
1 to 10 of 1,378Source NIH's project files
See all 1,378 nih grantsPapers1,588
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| When Neutrophils Do Not Die: Senescence as a New Axis of Tumor Immunosuppression. | Cancer Discov | 2026 | 42817716 | PubTator, text mining | PubMed |
| Clock-Related Genes Mark a Developmental Cortical Maturation Program Associated with Stage-Resolved Responses to Prenatal Immune Activation. | Genes (Basel) | 2026 | 42793001 | PubTator, text mining | PubMed |
| Trimester-specific associations of methyl-donor nutrients and prenatal dietary patterns with adolescent blood leukocyte circadian gene DNA methylation. | J Dev Orig Health Dis | 2026 | 42788273 | PubTator, text mining | PubMed |
| Single-cell RNA-seq analysis revealed that BHLHE40 and its binding protein THBS1 are involved in diabetic corneal epitheliopathy. | Exp Eye Res | 2026 | 42697405 | PubTator, text mining | PubMed |
| BHLHE40 and ChREBP associate with hepatic enhancer clusters containing PPARα, RXRα, and HNF4 nuclear receptors. | Endocrinology | 2026 | 42626966 | PubTator, text mining | PubMed |
| Modulation of neuronal excitability and plasticity by BHLHE41 conveys lithium non-responsiveness. | Mol Psychiatry | 2026 | 42613416 | PubTator, text mining | PubMed |
| Integrative Transcriptomics Links Dapagliflozin-Opposed Macrophage Programs to BHLHE40-Associated Regulation and NFKB1-Associated Signaling in HFpEF. | OMICS | 2026 | 42605950 | PubTator, text mining | PubMed |
| A machine learning-derived and functionally validated circadian rhythm signature predicts clinical outcomes and in silico drug sensitivity in colorectal cancer. | Transl Oncol | 2026 | 42520477 | PubTator, text mining | PubMed |
| Intratumoral Hypoxia Triggers Mitochondrial BHLHE40 ROS Sensing Pathway to Promote Radioresistance in Triple-Negative Breast Cancer. | Adv Sci (Weinh) | 2026 | 42505118 | PubTator, text mining | PubMed |
| BHLHE40/DEC1 programs epidermal Langerhans cell identity. | J Invest Dermatol | 2026 | 42492657 | PubTator, text mining | PubMed |
1 to 10 of 1,588
See all 1,588 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/8553
GET https://conductscience.org/api/genes/v1/8553/patents?page=2