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Gene · 8564

KMO: kynurenine 3-monooxygenase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. KMO: kynurenine 3-monooxygenase. Genes, record 8564. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8564

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Gene

Symbol
KMO
HGNC
Name
kynurenine 3-monooxygenase
HGNC
NCBI Gene ID
8564
NCBI Gene
HGNC ID
HGNC:6381
HGNC
Ensembl
ENSG00000117009
NCBI Gene
Aliases
dJ317G22.1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O15229Kynurenine 3-monooxygenase4861Ensembl, GeneID, HGNC

Source UniProt

Patents15

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1450998O15229Espacenet
EP 4641201 A22025-10-298206O15229Espacenet
JP 2025529142 A2025-09-042323O15229Espacenet
US 12371689 B22025-07-292323O15229Espacenet
JP 2025517969 A2025-06-128206O15229Espacenet
US 11446398 B22022-09-2044698O15229Espacenet
US 11400116 B22022-08-022869O15229Espacenet
JP 2022524081 A2022-04-27147669O15229Espacenet
US 11078247 B22021-08-035991O15229Espacenet
EP 3585909 A12020-01-01273O15229Espacenet

1 to 10 of 15

See all 15 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants707

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleKMO papersNewest fiscal year
P20GM121312The Center for Neuroscience-based Mental Health Assessment and Prediction (NeuroMAP)62025
I01BX003195Role of Brain-Derived Neurotrophic Factor in Regulating Neuroinflammation in Mental Health42025
P30CA016672Cancer Center Support Grant42025
P30AG038070Nathan Shock Center for Excellence in Basic Biology of Aging32025
P30CA008748Cancer Center Support Grant32025
P30EY011373CWRU NEI Vision Center Core Grant32025
R01LM012806Predicting Phenotype by Deep Learning Heterogeneous Multi-Omics Data32025
UL1TR001436Clinical and Translational Science Award32025
P20GM103476Mississippi INBRE22025
P20GM121334Mississippi Center of Excellence in Perinatal Research, Phase 222025

1 to 10 of 707Source NIH's project files

See all 707 nih grants

Papers1,472

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
A kynurenine immune-metabolic subtype of depression defined by childhood maltreatment and IDO2: Evidence from multi-omics profiling.Psychol Med202642803521PubTator, text miningPubMed
Biallelic Variants in KMO Cause a Novel Form of Congenital NAD Deficiency.medRxiv202642798303PubTator, text miningPubMed
Pharmacology-Informed Human Genetic Evaluation of Panax notoginseng Saponin-Related Candidate Genes for Functional Outcome After Ischemic Stroke Using Mendelian Randomization and Colocalization.Genes (Basel)202642793049PubTator, text miningPubMed
Kynurenine pathway dysregulation in attention-deficit hyperactivity disorder: Impact on N-methyl-D-aspartate receptors and phasic dopamine maturation.World J Clin Pediatr202642625969PubTator, text miningPubMed
The role of the kynurenine pathway in the pathogenesis of pain and affective disorders after traumatic brain injury.Brain Behav Immun Health202642577036PubTator, text miningPubMed
Integrative analysis of transcriptomics and metabolomics reveals mitochondria function genes and associated metabolite pathways in endometritis.Gene202642457000PubTator, text miningPubMed
Exploring the Microbiome-Kynurenine Axis in Mild Cognitive Impairment: From Gut to Brain.J Integr Neurosci202642411439PubTator, text miningPubMed
Domino Effect of the Kynurenine Pathway: Systemic Homeostasis, Metabolic Crosstalk, and Therapeutic Potential.Compr Physiol202642381240PubTator, text miningPubMed
Tryptophan Metabolism in Cardiometabolic Diseases: Focus on the Kynurenine Pathway.Int J Mol Sci202642352946PubTator, text miningPubMed
Kynurenine pathway at the crossroads of neurological and psychiatric disorders: Bridging metabolic dysregulation, therapeutic challenges, and emerging strategies.Prog Neuropsychopharmacol Biol Psychiatry202642315009PubTator, text miningPubMed

1 to 10 of 1,472

See all 1,472 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/8564

GET https://conductscience.org/api/genes/v1/8564/patents