Gene · 8564
KMO: kynurenine 3-monooxygenase
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. KMO: kynurenine 3-monooxygenase. Genes, record 8564. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8564
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O15229 | Kynurenine 3-monooxygenase | 486 | 1 | Ensembl, GeneID, HGNC |
Source UniProt
Patents15
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 50998 | O15229 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 8206 | O15229 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 2323 | O15229 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 2323 | O15229 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 8206 | O15229 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 44698 | O15229 | Espacenet |
| US 11400116 B2 | 2022-08-02 | 2869 | O15229 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 147669 | O15229 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 5991 | O15229 | Espacenet |
| EP 3585909 A1 | 2020-01-01 | 273 | O15229 | Espacenet |
1 to 10 of 15
See all 15 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants707
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | KMO papers | Newest fiscal year |
|---|---|---|---|
| P20GM121312 | The Center for Neuroscience-based Mental Health Assessment and Prediction (NeuroMAP) | 6 | 2025 |
| I01BX003195 | Role of Brain-Derived Neurotrophic Factor in Regulating Neuroinflammation in Mental Health | 4 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 4 | 2025 |
| P30AG038070 | Nathan Shock Center for Excellence in Basic Biology of Aging | 3 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 3 | 2025 |
| P30EY011373 | CWRU NEI Vision Center Core Grant | 3 | 2025 |
| R01LM012806 | Predicting Phenotype by Deep Learning Heterogeneous Multi-Omics Data | 3 | 2025 |
| UL1TR001436 | Clinical and Translational Science Award | 3 | 2025 |
| P20GM103476 | Mississippi INBRE | 2 | 2025 |
| P20GM121334 | Mississippi Center of Excellence in Perinatal Research, Phase 2 | 2 | 2025 |
1 to 10 of 707Source NIH's project files
See all 707 nih grantsPapers1,472
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| A kynurenine immune-metabolic subtype of depression defined by childhood maltreatment and IDO2: Evidence from multi-omics profiling. | Psychol Med | 2026 | 42803521 | PubTator, text mining | PubMed |
| Biallelic Variants in KMO Cause a Novel Form of Congenital NAD Deficiency. | medRxiv | 2026 | 42798303 | PubTator, text mining | PubMed |
| Pharmacology-Informed Human Genetic Evaluation of Panax notoginseng Saponin-Related Candidate Genes for Functional Outcome After Ischemic Stroke Using Mendelian Randomization and Colocalization. | Genes (Basel) | 2026 | 42793049 | PubTator, text mining | PubMed |
| Kynurenine pathway dysregulation in attention-deficit hyperactivity disorder: Impact on N-methyl-D-aspartate receptors and phasic dopamine maturation. | World J Clin Pediatr | 2026 | 42625969 | PubTator, text mining | PubMed |
| The role of the kynurenine pathway in the pathogenesis of pain and affective disorders after traumatic brain injury. | Brain Behav Immun Health | 2026 | 42577036 | PubTator, text mining | PubMed |
| Integrative analysis of transcriptomics and metabolomics reveals mitochondria function genes and associated metabolite pathways in endometritis. | Gene | 2026 | 42457000 | PubTator, text mining | PubMed |
| Exploring the Microbiome-Kynurenine Axis in Mild Cognitive Impairment: From Gut to Brain. | J Integr Neurosci | 2026 | 42411439 | PubTator, text mining | PubMed |
| Domino Effect of the Kynurenine Pathway: Systemic Homeostasis, Metabolic Crosstalk, and Therapeutic Potential. | Compr Physiol | 2026 | 42381240 | PubTator, text mining | PubMed |
| Tryptophan Metabolism in Cardiometabolic Diseases: Focus on the Kynurenine Pathway. | Int J Mol Sci | 2026 | 42352946 | PubTator, text mining | PubMed |
| Kynurenine pathway at the crossroads of neurological and psychiatric disorders: Bridging metabolic dysregulation, therapeutic challenges, and emerging strategies. | Prog Neuropsychopharmacol Biol Psychiatry | 2026 | 42315009 | PubTator, text mining | PubMed |
1 to 10 of 1,472
See all 1,472 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
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The record and each of its lists are JSON, twenty rows a page. No key.
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