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Gene · 8622

PDE8B: phosphodiesterase 8B

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PDE8B: phosphodiesterase 8B. Genes, record 8622. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8622

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Gene

Symbol
PDE8B
HGNC
Name
phosphodiesterase 8B
HGNC
NCBI Gene ID
8622
NCBI Gene
HGNC ID
HGNC:8794
HGNC
Ensembl
ENSG00000113231
NCBI Gene
Aliases
ADSD, PPNAD3
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O95263High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B8850Ensembl, GeneID, HGNC

Source UniProt

Patents33

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1457770O95263Espacenet
EP 4641201 A22025-10-291992O95263Espacenet
JP 2025517969 A2025-06-121992O95263Espacenet
JP 2025032204 A2025-03-1133197O95263Espacenet
JP 2025004127 A2025-01-1419O95263Espacenet
EP 4461818 A22024-11-1333197O95263Espacenet
EP 4373841 A12024-05-2929O95263Espacenet
EP 4374872 A12024-05-29112O95263Espacenet
JP 2023144094 A2023-10-06139O95263Espacenet
US 11666642 B22023-06-06139O95263Espacenet

1 to 10 of 33

See all 33 patents

Drugs4

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
DIPYRIDAMOLECHEMBL9323',5'-cyclic phosphodiesterase inhibitorINHIBITORChEMBL
FLAVOXATECHEMBL1493Phosphodiesterase 8 inhibitorINHIBITORChEMBL
FLAVOXATE HYDROCHLORIDECHEMBL1200875Phosphodiesterase 8 inhibitorINHIBITORChEMBL
PENTOXIFYLLINECHEMBL6283',5'-cyclic phosphodiesterase inhibitorINHIBITORChEMBL

Trials135

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07349472PENTOXIFYLLINEPHASE2ClinicalTrials.gov
NCT07315139PENTOXIFYLLINEClinicalTrials.gov
NCT07252518PENTOXIFYLLINEClinicalTrials.gov
NCT07199504DIPYRIDAMOLEPHASE2/PHASE3ClinicalTrials.gov
NCT07088328PENTOXIFYLLINEClinicalTrials.gov
NCT07086794PENTOXIFYLLINEEARLY_PHASE1ClinicalTrials.gov
NCT07085806PENTOXIFYLLINEClinicalTrials.gov
NCT06998628PENTOXIFYLLINEPHASE2ClinicalTrials.gov
NCT06986031PENTOXIFYLLINEPHASE2ClinicalTrials.gov
NCT06912763PENTOXIFYLLINEPHASE2ClinicalTrials.gov

1 to 10 of 135

See all 135 trials

NIH grants346

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePDE8B papersNewest fiscal year
R01DK062027Mechanisms of Adrenal Differentiation52025
P30DK020572Michigan Diabetes Research Center (MDRC)32025
P30ES005605Environmental Health Sciences Research Center22025
R01DK062370Identifying Genes for Type 2 Diabetes: FUSION22025
ZIAAG000965The Aging Genome Association Study "AGE-GAIN"22025
ZIAHG000024Genetic analysis of type II diabetes22025
ZICES102445Gene Expression and Microarrays22025
ZIEHD008944Pediatric Endocrinology Training Program22025
P01CA163227Androgen Receptor Action in Castration Resistant Prostate Cancer12025
P30AG066515Stanford Alzheimer's Disease Research Center12025

1 to 10 of 346Source NIH's project files

See all 346 nih grants

Papers459

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Roles of External Factors and Polygenic Susceptibility in Thyroid Nodules and Goiter Among Children Aged 8-10 Years in Iodine-adequate Areas of Northern China.Biol Trace Elem Res202642599577PubTator, text miningPubMed
Phosphodiesterase 8 (PDE8), a novel target for neurodegenerative diseases.Cell Signal202642251942PubTator, text miningPubMed
Bilateral macronodular and micronodular hyperplasia: Biochemical, radiological and genetic diagnosis.Vitam Horm202642236017PubTator, text miningPubMed
cAMP/PKA signaling in endocrine hypertension: genetic mechanisms and pathophysiological insights.Front Endocrinol (Lausanne)202641816209PubTator, text miningPubMed
Molecular pathology of primary aldosteronism and hypercortisolism: Impact on adrenal surgery.iScience202641736857PubTator, text miningPubMed
A Multimodal Single-Cell Epigenomic and 3D Genome Atlas of the Human Basal Ganglia.bioRxiv202641726865PubTator, text miningPubMed
Family-Wide Dysregulation of Phosphodiesterases Alters cAMP/cGMP Microdomains in Thoracic Aortic Aneurysm.J Cardiovasc Dev Dis202641590850PubTator, text miningPubMed
Integrative multi-omics analyses identify key genes and elucidate bidirectional regulatory mechanisms in thyroid dysfunction.PLoS One202641570039PubTator, text miningPubMed
Effects of nucleic acid metabolism on prognosis and immune invasion of triple-negative breast cancer.Genes Immun202641198929PubTator, text miningPubMed
Pan-Cancer Analysis of Cyclic Nucleotide Phosphodiesterases (PDEs) Expression, Variation, and Prognostic Significance.ACS Omega202541476499PubTator, text miningPubMed

1 to 10 of 459

See all 459 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/8622

GET https://conductscience.org/api/genes/v1/8622/patents?page=2