Gene · 8622
PDE8B: phosphodiesterase 8B
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. PDE8B: phosphodiesterase 8B. Genes, record 8622. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8622
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O95263 | High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B | 885 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents33
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 57770 | O95263 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 1992 | O95263 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 1992 | O95263 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 33197 | O95263 | Espacenet |
| JP 2025004127 A | 2025-01-14 | 19 | O95263 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 33197 | O95263 | Espacenet |
| EP 4373841 A1 | 2024-05-29 | 29 | O95263 | Espacenet |
| EP 4374872 A1 | 2024-05-29 | 112 | O95263 | Espacenet |
| JP 2023144094 A | 2023-10-06 | 139 | O95263 | Espacenet |
| US 11666642 B2 | 2023-06-06 | 139 | O95263 | Espacenet |
1 to 10 of 33
See all 33 patentsDrugs4
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| DIPYRIDAMOLE | CHEMBL932 | 3',5'-cyclic phosphodiesterase inhibitor | INHIBITOR | ChEMBL |
| FLAVOXATE | CHEMBL1493 | Phosphodiesterase 8 inhibitor | INHIBITOR | ChEMBL |
| FLAVOXATE HYDROCHLORIDE | CHEMBL1200875 | Phosphodiesterase 8 inhibitor | INHIBITOR | ChEMBL |
| PENTOXIFYLLINE | CHEMBL628 | 3',5'-cyclic phosphodiesterase inhibitor | INHIBITOR | ChEMBL |
Trials135
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07349472 | PENTOXIFYLLINE | PHASE2 | ClinicalTrials.gov | |
| NCT07315139 | PENTOXIFYLLINE | ClinicalTrials.gov | ||
| NCT07252518 | PENTOXIFYLLINE | ClinicalTrials.gov | ||
| NCT07199504 | DIPYRIDAMOLE | PHASE2/PHASE3 | ClinicalTrials.gov | |
| NCT07088328 | PENTOXIFYLLINE | ClinicalTrials.gov | ||
| NCT07086794 | PENTOXIFYLLINE | EARLY_PHASE1 | ClinicalTrials.gov | |
| NCT07085806 | PENTOXIFYLLINE | ClinicalTrials.gov | ||
| NCT06998628 | PENTOXIFYLLINE | PHASE2 | ClinicalTrials.gov | |
| NCT06986031 | PENTOXIFYLLINE | PHASE2 | ClinicalTrials.gov | |
| NCT06912763 | PENTOXIFYLLINE | PHASE2 | ClinicalTrials.gov |
1 to 10 of 135
See all 135 trialsNIH grants346
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | PDE8B papers | Newest fiscal year |
|---|---|---|---|
| R01DK062027 | Mechanisms of Adrenal Differentiation | 5 | 2025 |
| P30DK020572 | Michigan Diabetes Research Center (MDRC) | 3 | 2025 |
| P30ES005605 | Environmental Health Sciences Research Center | 2 | 2025 |
| R01DK062370 | Identifying Genes for Type 2 Diabetes: FUSION | 2 | 2025 |
| ZIAAG000965 | The Aging Genome Association Study "AGE-GAIN" | 2 | 2025 |
| ZIAHG000024 | Genetic analysis of type II diabetes | 2 | 2025 |
| ZICES102445 | Gene Expression and Microarrays | 2 | 2025 |
| ZIEHD008944 | Pediatric Endocrinology Training Program | 2 | 2025 |
| P01CA163227 | Androgen Receptor Action in Castration Resistant Prostate Cancer | 1 | 2025 |
| P30AG066515 | Stanford Alzheimer's Disease Research Center | 1 | 2025 |
1 to 10 of 346Source NIH's project files
See all 346 nih grantsPapers459
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Roles of External Factors and Polygenic Susceptibility in Thyroid Nodules and Goiter Among Children Aged 8-10 Years in Iodine-adequate Areas of Northern China. | Biol Trace Elem Res | 2026 | 42599577 | PubTator, text mining | PubMed |
| Phosphodiesterase 8 (PDE8), a novel target for neurodegenerative diseases. | Cell Signal | 2026 | 42251942 | PubTator, text mining | PubMed |
| Bilateral macronodular and micronodular hyperplasia: Biochemical, radiological and genetic diagnosis. | Vitam Horm | 2026 | 42236017 | PubTator, text mining | PubMed |
| cAMP/PKA signaling in endocrine hypertension: genetic mechanisms and pathophysiological insights. | Front Endocrinol (Lausanne) | 2026 | 41816209 | PubTator, text mining | PubMed |
| Molecular pathology of primary aldosteronism and hypercortisolism: Impact on adrenal surgery. | iScience | 2026 | 41736857 | PubTator, text mining | PubMed |
| A Multimodal Single-Cell Epigenomic and 3D Genome Atlas of the Human Basal Ganglia. | bioRxiv | 2026 | 41726865 | PubTator, text mining | PubMed |
| Family-Wide Dysregulation of Phosphodiesterases Alters cAMP/cGMP Microdomains in Thoracic Aortic Aneurysm. | J Cardiovasc Dev Dis | 2026 | 41590850 | PubTator, text mining | PubMed |
| Integrative multi-omics analyses identify key genes and elucidate bidirectional regulatory mechanisms in thyroid dysfunction. | PLoS One | 2026 | 41570039 | PubTator, text mining | PubMed |
| Effects of nucleic acid metabolism on prognosis and immune invasion of triple-negative breast cancer. | Genes Immun | 2026 | 41198929 | PubTator, text mining | PubMed |
| Pan-Cancer Analysis of Cyclic Nucleotide Phosphodiesterases (PDEs) Expression, Variation, and Prognostic Significance. | ACS Omega | 2025 | 41476499 | PubTator, text mining | PubMed |
1 to 10 of 459
See all 459 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/8622
GET https://conductscience.org/api/genes/v1/8622/patents?page=2