Gene · 8698
S1PR4: sphingosine-1-phosphate receptor 4
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. S1PR4: sphingosine-1-phosphate receptor 4. Genes, record 8698. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8698
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O95977 | Sphingosine 1-phosphate receptor 4 | 384 | 1 | Ensembl, GeneID, HGNC |
Source UniProt
Patents38
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 65288 | O95977 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 3813 | O95977 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 3813 | O95977 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 83473 | O95977 | Espacenet |
| US 11400116 B2 | 2022-08-02 | 2889 | O95977 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 186444 | O95977 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 9902 | O95977 | Espacenet |
| US 10772934 B2 | 2020-09-15 | 1003 | O95977 | Espacenet |
| US 10292374 B2 | 2019-05-21 | 396 | O95977 | Espacenet |
| JP 2019054813 A | 2019-04-11 | 245723 | O95977 | Espacenet |
1 to 10 of 38
See all 38 patentsDrugs8
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| AMISELIMOD | CHEMBL3707375 | Sphingosine 1-phosphate receptor modulator | MODULATOR | ChEMBL |
| AMISELIMOD HYDROCHLORIDE | CHEMBL3707374 | Sphingosine 1-phosphate receptor modulator | MODULATOR | ChEMBL |
| ETRASIMOD | CHEMBL3358920 | Sphingosine 1-phosphate receptor Edg-6 modulator | MODULATOR | ChEMBL |
| ETRASIMOD ARGININE | CHEMBL3989933 | Sphingosine 1-phosphate receptor Edg-6 modulator | MODULATOR | ChEMBL |
| FINGOLIMOD | CHEMBL314854 | Sphingosine 1-phosphate receptor agonist | AGONIST | ChEMBL |
| FINGOLIMOD | CHEMBL314854 | Sphingosine 1-phosphate receptor binding agent | BINDING AGENT | ChEMBL |
| FINGOLIMOD HYDROCHLORIDE | CHEMBL544665 | Sphingosine 1-phosphate receptor agonist | AGONIST | ChEMBL |
| FINGOLIMOD LAURYL SULFATE | CHEMBL5095050 | Sphingosine 1-phosphate receptor binding agent | BINDING AGENT | ChEMBL |
Trials106
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07483632 | FINGOLIMOD | PHASE3 | ClinicalTrials.gov | |
| NCT07470879 | ETRASIMOD | PHASE2 | ClinicalTrials.gov | |
| NCT07459686 | ETRASIMOD ARGININE | ClinicalTrials.gov | ||
| NCT07243639 | ETRASIMOD | ClinicalTrials.gov | ||
| NCT07220252 | FINGOLIMOD | PHASE2/PHASE3 | ClinicalTrials.gov | |
| NCT06424067 | FINGOLIMOD | PHASE2 | ClinicalTrials.gov | |
| NCT06408259 | FINGOLIMOD | PHASE3 | ClinicalTrials.gov | |
| NCT06398626 | ETRASIMOD | ClinicalTrials.gov | ||
| NCT06294925 | ETRASIMOD | ClinicalTrials.gov | ||
| NCT06087965 | FINGOLIMOD | PHASE1/PHASE2 | ClinicalTrials.gov |
1 to 10 of 106
See all 106 trialsNIH grants628
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | S1PR4 papers | Newest fiscal year |
|---|---|---|---|
| P01CA097132 | Sphingolipids in Cancer Biology and Therapy | 8 | 2025 |
| IK6BX004477 | BLR&D Research Career Scientist Award Application | 3 | 2025 |
| P30CA016056 | Roswell Park Cancer Center Support Grant | 3 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 3 | 2025 |
| ZIADK056014 | Mouse Models of Novel Sphingolipid Biology and Disease Mechanisms | 3 | 2025 |
| P30AI073961 | Miami Center for AIDS Research | 2 | 2025 |
| P30AI117970 | District of Columbia Center for AIDS Research | 2 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 2 | 2025 |
| P30CA016059 | Massey Cancer Center - Cancer Center Support Grant | 2 | 2025 |
| P30CA021765 | Cancer Center Support Grant (CCSG) | 2 | 2025 |
1 to 10 of 628Source NIH's project files
See all 628 nih grantsPapers982
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| [Pharmacological properties and clinical efficacy of sphingosine 1-phosphate (S1P) receptor modulator, Etrasimod (Velsipity® 2 mg tablets)]. | Nihon Yakurigaku Zasshi | 2026 | 42686559 | PubTator, text mining | PubMed |
| Fungal Infections Associated with Sphingosine 1-Phosphate Receptor Modulators: Immunological Mechanisms, Clinical Patterns, and Management Considerations. | Microorganisms | 2026 | 42655205 | PubTator, text mining | PubMed |
| Adenosine Pathway-Based Prognostic Signature for Predicting Clinical Outcomes and Immune Microenvironment Characteristics in Epithelial Ovarian Cancer. | J Clin Pract Res | 2026 | 42416131 | PubTator, text mining | PubMed |
| Circulating sphingosine-1-phosphate depletion is associated with endothelial activation and altered brain-endothelial S1P pathway expression in ischemic stroke. | Fluids Barriers CNS | 2026 | 42277837 | PubTator, text mining | PubMed |
| Glycolytic reprogramming in endometriosis: molecular mechanisms, immune modulation, and non-hormonal therapeutic opportunities. | BMC Womens Health | 2026 | 42186039 | PubTator, text mining | PubMed |
| Comprehensive bioinformatics analysis targeting sphingosine-related genes in head and neck cancer. | Discov Oncol | 2026 | 42168685 | PubTator, text mining | PubMed |
| In vitro metabolism and inhibitory effect of vonifimod on drug-metabolizing enzymes in human liver preparations. | Toxicol Res | 2026 | 42021864 | PubTator, text mining | PubMed |
| Structural insights into subtype-specific agonist recognition by sphingosine-1-phosphate receptors. | PLoS Biol | 2026 | 41961881 | PubTator, text mining | PubMed |
| In Vitro Modeling of Age-Associated Lipid Mediator's Impact on Vascular Biology Following Platelet Concentrate Transfusion. | Aging Cell | 2026 | 41922292 | PubTator, text mining | PubMed |
| Extracellular Vesicles Associated Metabolites as Intercellular Signalling Mediators in Disease and Therapy. | Metabolites | 2026 | 41893356 | PubTator, text mining | PubMed |
1 to 10 of 982
See all 982 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/8698
GET https://conductscience.org/api/genes/v1/8698/patents?page=2