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Gene · 8698

S1PR4: sphingosine-1-phosphate receptor 4

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. S1PR4: sphingosine-1-phosphate receptor 4. Genes, record 8698. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8698

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Gene

Symbol
S1PR4
HGNC
Name
sphingosine-1-phosphate receptor 4
HGNC
NCBI Gene ID
8698
NCBI Gene
HGNC ID
HGNC:3170
HGNC
Ensembl
ENSG00000125910
NCBI Gene
Aliases
EDG6, LPC1, S1P4, SLP4
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O95977Sphingosine 1-phosphate receptor 43841Ensembl, GeneID, HGNC

Source UniProt

Patents38

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1465288O95977Espacenet
JP 2025529142 A2025-09-043813O95977Espacenet
US 12371689 B22025-07-293813O95977Espacenet
US 11446398 B22022-09-2083473O95977Espacenet
US 11400116 B22022-08-022889O95977Espacenet
JP 2022524081 A2022-04-27186444O95977Espacenet
US 11078247 B22021-08-039902O95977Espacenet
US 10772934 B22020-09-151003O95977Espacenet
US 10292374 B22019-05-21396O95977Espacenet
JP 2019054813 A2019-04-11245723O95977Espacenet

1 to 10 of 38

See all 38 patents

Drugs8

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AMISELIMODCHEMBL3707375Sphingosine 1-phosphate receptor modulatorMODULATORChEMBL
AMISELIMOD HYDROCHLORIDECHEMBL3707374Sphingosine 1-phosphate receptor modulatorMODULATORChEMBL
ETRASIMODCHEMBL3358920Sphingosine 1-phosphate receptor Edg-6 modulatorMODULATORChEMBL
ETRASIMOD ARGININECHEMBL3989933Sphingosine 1-phosphate receptor Edg-6 modulatorMODULATORChEMBL
FINGOLIMODCHEMBL314854Sphingosine 1-phosphate receptor agonistAGONISTChEMBL
FINGOLIMODCHEMBL314854Sphingosine 1-phosphate receptor binding agentBINDING AGENTChEMBL
FINGOLIMOD HYDROCHLORIDECHEMBL544665Sphingosine 1-phosphate receptor agonistAGONISTChEMBL
FINGOLIMOD LAURYL SULFATECHEMBL5095050Sphingosine 1-phosphate receptor binding agentBINDING AGENTChEMBL

Trials106

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07483632FINGOLIMODPHASE3ClinicalTrials.gov
NCT07470879ETRASIMODPHASE2ClinicalTrials.gov
NCT07459686ETRASIMOD ARGININEClinicalTrials.gov
NCT07243639ETRASIMODClinicalTrials.gov
NCT07220252FINGOLIMODPHASE2/PHASE3ClinicalTrials.gov
NCT06424067FINGOLIMODPHASE2ClinicalTrials.gov
NCT06408259FINGOLIMODPHASE3ClinicalTrials.gov
NCT06398626ETRASIMODClinicalTrials.gov
NCT06294925ETRASIMODClinicalTrials.gov
NCT06087965FINGOLIMODPHASE1/PHASE2ClinicalTrials.gov

1 to 10 of 106

See all 106 trials

NIH grants628

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleS1PR4 papersNewest fiscal year
P01CA097132Sphingolipids in Cancer Biology and Therapy82025
IK6BX004477BLR&D Research Career Scientist Award Application32025
P30CA016056Roswell Park Cancer Center Support Grant32025
UL1TR001863Yale Clinical and Translational Science Award32025
ZIADK056014Mouse Models of Novel Sphingolipid Biology and Disease Mechanisms32025
P30AI073961Miami Center for AIDS Research22025
P30AI117970District of Columbia Center for AIDS Research22025
P30CA008748Cancer Center Support Grant22025
P30CA016059Massey Cancer Center - Cancer Center Support Grant22025
P30CA021765Cancer Center Support Grant (CCSG)22025

1 to 10 of 628Source NIH's project files

See all 628 nih grants

Papers982

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
[Pharmacological properties and clinical efficacy of sphingosine 1-phosphate (S1P) receptor modulator, Etrasimod (Velsipity® 2 mg tablets)].Nihon Yakurigaku Zasshi202642686559PubTator, text miningPubMed
Fungal Infections Associated with Sphingosine 1-Phosphate Receptor Modulators: Immunological Mechanisms, Clinical Patterns, and Management Considerations.Microorganisms202642655205PubTator, text miningPubMed
Adenosine Pathway-Based Prognostic Signature for Predicting Clinical Outcomes and Immune Microenvironment Characteristics in Epithelial Ovarian Cancer.J Clin Pract Res202642416131PubTator, text miningPubMed
Circulating sphingosine-1-phosphate depletion is associated with endothelial activation and altered brain-endothelial S1P pathway expression in ischemic stroke.Fluids Barriers CNS202642277837PubTator, text miningPubMed
Glycolytic reprogramming in endometriosis: molecular mechanisms, immune modulation, and non-hormonal therapeutic opportunities.BMC Womens Health202642186039PubTator, text miningPubMed
Comprehensive bioinformatics analysis targeting sphingosine-related genes in head and neck cancer.Discov Oncol202642168685PubTator, text miningPubMed
In vitro metabolism and inhibitory effect of vonifimod on drug-metabolizing enzymes in human liver preparations.Toxicol Res202642021864PubTator, text miningPubMed
Structural insights into subtype-specific agonist recognition by sphingosine-1-phosphate receptors.PLoS Biol202641961881PubTator, text miningPubMed
In Vitro Modeling of Age-Associated Lipid Mediator's Impact on Vascular Biology Following Platelet Concentrate Transfusion.Aging Cell202641922292PubTator, text miningPubMed
Extracellular Vesicles Associated Metabolites as Intercellular Signalling Mediators in Disease and Therapy.Metabolites202641893356PubTator, text miningPubMed

1 to 10 of 982

See all 982 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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