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Gene · 8742

TNFSF12: TNF superfamily member 12

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TNFSF12: TNF superfamily member 12. Genes, record 8742. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8742

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Gene

Symbol
TNFSF12
HGNC
Name
TNF superfamily member 12
HGNC
NCBI Gene ID
8742
NCBI Gene
HGNC ID
HGNC:11927
HGNC
Ensembl
ENSG00000239697
NCBI Gene
Aliases
APO3L, DR3LG, TNF12, TNLG4A, TWEAK
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O43508Tumor necrosis factor ligand superfamily member 122491Ensembl, GeneID, HGNC

Source UniProt

Patents247

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026086743 A2026-05-26188O43508Espacenet
JP 2026004568 A2026-01-1468635O43508Espacenet
EP 4650780 A22025-11-193541O43508Espacenet
JP 2025147176 A2025-10-0613611O43508Espacenet
JP 2025147176 A2025-10-0616535O43508Espacenet
JP 2025147176 A2025-10-0616793O43508Espacenet
JP 2025529142 A2025-09-047945O43508Espacenet
US 12371689 B22025-07-297945O43508Espacenet
JP 2025517970 A2025-06-123541O43508Espacenet
JP 2025028160 A2025-02-2813611O43508Espacenet

1 to 10 of 247

See all 247 patents

Drugs2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
BIIB-023CHEMBL2109598Tumor necrosis factor ligand superfamily member 12 inhibitorINHIBITORChEMBL
RO-5458640CHEMBL2109600Tumor necrosis factor ligand superfamily member 12 inhibitorINHIBITORChEMBL

Trials4

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT01943513BIIB-023PHASE1ClinicalTrials.gov
NCT01930890BIIB-023PHASE22017-01-18ClinicalTrials.gov
NCT01499355BIIB-023PHASE22017-01-18ClinicalTrials.gov
NCT00771329BIIB-023PHASE1ClinicalTrials.gov

NIH grants1,546

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTNFSF12 papersNewest fiscal year
P30CA016672Cancer Center Support Grant92025
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant52025
R01AR074096Monitoring Disease in Lupus52025
T32HL007698Interdisciplinary Training Program in Cardiovascular Disease52025
U54GM104938Oklahoma Shared Clinical and Translational Resources52025
P30CA134274UNIVERSITY OF MARYLAND GREENEBAUM CANCER CENTERSUPPORT GRANT42025
P30DK084567Mayo Center for Cell Signaling in Gastroenterology42025
T32CA154274Training Grant in Cancer Biology42025
ZIABC011176Functions of KSHV microRNAs and circular RNAs42025
P30AR075043University of Michigan Skin Biology and Diseases Resource-based Center32025

1 to 10 of 1,546Source NIH's project files

See all 1,546 nih grants

Papers2,943

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Circulating Inflammatory Markers and Mammographic Density Phenotypes: a Mendelian Randomization Analysis.medRxiv202642818447PubTator, text miningPubMed
Inflammatory Cytokines as Mediators of the Association between Obesity and Chronic Apical Periodontitis.J Endod202642810676PubTator, text miningPubMed
Network of interactions between the tumor necrosis factor superfamily members and small S100 proteins.PLoS One202642809589PubTator, text miningPubMed
The Polycystic Kidney Disease Cyst Transcriptome Defined by Integrating Spatial, Single Nuclear, and Bulk Transcriptomics.Kidney360202642804341PubTator, text miningPubMed
Genetically Predicted Gut Microbial Taxa and Inflammatory Proteins Associated With Atrial Fibrillation: A Bidirectional Mendelian Randomization and Colocalization Study.J Arrhythm202642798960PubTator, text miningPubMed
Bevacizumab plus nab-paclitaxel and platinum as second-line therapy for driver-gene-negative non-squamous non-small cell lung cancer after immunochemotherapy: A prospective single-arm single-centre study.
Clin Transl Med202642723577PubTator, text miningPubMed
TRANCE is a unique marker of chronic pancreatitis in children.JCI Insight202642635043PubTator, text miningPubMed
Distinct Inflammatory Immune Signature in Acute Mpox Associated With Proctitis.Open Forum Infect Dis202642568779PubTator, text miningPubMed
[Bidirectional two-sample MR analysis of causal relationships between human inflammatory proteins and HS and keloids].Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi202642547441PubTator, text miningPubMed
Elevated FN14 expression promotes proliferation, chemoresistance, and impairment of differentiation in rhabdomyosarcoma.Cancer Lett202642521076PubTator, text miningPubMed

1 to 10 of 2,943

See all 2,943 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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