Gene · 8742
TNFSF12: TNF superfamily member 12
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. TNFSF12: TNF superfamily member 12. Genes, record 8742. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8742
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O43508 | Tumor necrosis factor ligand superfamily member 12 | 249 | 1 | Ensembl, GeneID, HGNC |
Source UniProt
Patents247
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026086743 A | 2026-05-26 | 188 | O43508 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 68635 | O43508 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 3541 | O43508 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 13611 | O43508 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 16535 | O43508 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 16793 | O43508 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 7945 | O43508 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 7945 | O43508 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 3541 | O43508 | Espacenet |
| JP 2025028160 A | 2025-02-28 | 13611 | O43508 | Espacenet |
1 to 10 of 247
See all 247 patentsDrugs2
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
Trials4
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT01943513 | BIIB-023 | PHASE1 | ClinicalTrials.gov | |
| NCT01930890 | BIIB-023 | PHASE2 | 2017-01-18 | ClinicalTrials.gov |
| NCT01499355 | BIIB-023 | PHASE2 | 2017-01-18 | ClinicalTrials.gov |
| NCT00771329 | BIIB-023 | PHASE1 | ClinicalTrials.gov |
NIH grants1,546
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | TNFSF12 papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 9 | 2025 |
| P30CA015083 | Mayo Clinic Comprehensive Cancer Center Support Grant | 5 | 2025 |
| R01AR074096 | Monitoring Disease in Lupus | 5 | 2025 |
| T32HL007698 | Interdisciplinary Training Program in Cardiovascular Disease | 5 | 2025 |
| U54GM104938 | Oklahoma Shared Clinical and Translational Resources | 5 | 2025 |
| P30CA134274 | UNIVERSITY OF MARYLAND GREENEBAUM CANCER CENTERSUPPORT GRANT | 4 | 2025 |
| P30DK084567 | Mayo Center for Cell Signaling in Gastroenterology | 4 | 2025 |
| T32CA154274 | Training Grant in Cancer Biology | 4 | 2025 |
| ZIABC011176 | Functions of KSHV microRNAs and circular RNAs | 4 | 2025 |
| P30AR075043 | University of Michigan Skin Biology and Diseases Resource-based Center | 3 | 2025 |
1 to 10 of 1,546Source NIH's project files
See all 1,546 nih grantsPapers2,943
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Circulating Inflammatory Markers and Mammographic Density Phenotypes: a Mendelian Randomization Analysis. | medRxiv | 2026 | 42818447 | PubTator, text mining | PubMed |
| Inflammatory Cytokines as Mediators of the Association between Obesity and Chronic Apical Periodontitis. | J Endod | 2026 | 42810676 | PubTator, text mining | PubMed |
| Network of interactions between the tumor necrosis factor superfamily members and small S100 proteins. | PLoS One | 2026 | 42809589 | PubTator, text mining | PubMed |
| The Polycystic Kidney Disease Cyst Transcriptome Defined by Integrating Spatial, Single Nuclear, and Bulk Transcriptomics. | Kidney360 | 2026 | 42804341 | PubTator, text mining | PubMed |
| Genetically Predicted Gut Microbial Taxa and Inflammatory Proteins Associated With Atrial Fibrillation: A Bidirectional Mendelian Randomization and Colocalization Study. | J Arrhythm | 2026 | 42798960 | PubTator, text mining | PubMed |
Bevacizumab plus nab-paclitaxel and platinum as second-line therapy for driver-gene-negative non-squamous non-small cell lung cancer after immunochemotherapy: A prospective single-arm single-centre study. | Clin Transl Med | 2026 | 42723577 | PubTator, text mining | PubMed |
| TRANCE is a unique marker of chronic pancreatitis in children. | JCI Insight | 2026 | 42635043 | PubTator, text mining | PubMed |
| Distinct Inflammatory Immune Signature in Acute Mpox Associated With Proctitis. | Open Forum Infect Dis | 2026 | 42568779 | PubTator, text mining | PubMed |
| [Bidirectional two-sample MR analysis of causal relationships between human inflammatory proteins and HS and keloids]. | Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi | 2026 | 42547441 | PubTator, text mining | PubMed |
| Elevated FN14 expression promotes proliferation, chemoresistance, and impairment of differentiation in rhabdomyosarcoma. | Cancer Lett | 2026 | 42521076 | PubTator, text mining | PubMed |
1 to 10 of 2,943
See all 2,943 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/8742
GET https://conductscience.org/api/genes/v1/8742/patents?page=2