Gene · 8835
SOCS2: suppressor of cytokine signaling 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. SOCS2: suppressor of cytokine signaling 2. Genes, record 8835. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8835
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O14508 | Suppressor of cytokine signaling 2 | 198 | 13 | Ensembl, GeneID, HGNC |
Source UniProt
Patents112
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2025032204 A | 2025-03-11 | 36224 | O14508 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 36225 | O14508 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 36226 | O14508 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 36228 | O14508 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 36231 | O14508 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 36235 | O14508 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 36224 | O14508 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 36225 | O14508 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 36226 | O14508 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 36228 | O14508 | Espacenet |
1 to 10 of 112
See all 112 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,422
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | SOCS2 papers | Newest fiscal year |
|---|---|---|---|
| P30CA015704 | Cancer Center Support Grant | 4 | 2025 |
| P30CA016058 | Cancer Center Support Grant | 4 | 2025 |
| P30CA016086 | Cancer Center Support Grant | 4 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 4 | 2025 |
| P30CA023074 | University of Arizona Cancer Center - Cancer Center Support Grant | 4 | 2025 |
| P30CA051008 | Georgetown University Lombardi Comprehensive Cancer Center Support Grant | 4 | 2025 |
| P30DK020572 | Michigan Diabetes Research Center (MDRC) | 4 | 2025 |
| P30ES013508 | Center of Excellence in Environmental Toxicology | 4 | 2025 |
| R01ES025530 | Role of AHR in Dendritic Cells in the Control of CNS Autoimmunity | 4 | 2025 |
| P30AI027763 | UCSF-Bay Area Center for AIDS Research | 3 | 2025 |
1 to 10 of 1,422Source NIH's project files
See all 1,422 nih grantsPapers2,451
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| SOCS2 Downregulation Is Associated with a Ferro-Aging-Related Transcriptomic Signature in Proximal Tubular Cells in Chronic Kidney Disease. | Biomedicines | 2026 | 42792788 | PubTator, text mining | PubMed |
| Differential regulation of SOCS signalling and immunoproteasome pathways by JAK inhibitors and TNF inhibitors in rheumatoid arthritis. | Arthritis Res Ther | 2026 | 42745343 | PubTator, text mining | PubMed |
| Integrated Transcriptomic Analyses Identify Four Prognosis-Associated Genes in Hepatocellular Carcinoma. | Int J Mol Sci | 2026 | 42737438 | PubTator, text mining | PubMed |
| Extracellular Vesicles in Cardiovascular Disease: Intercellular Signaling, Liquid Biopsy Biomarkers, and Therapeutic Translation. | Circ Res | 2026 | 42594169 | PubTator, text mining | PubMed |
| Decoding the Complexity of Hepatocellular Carcinoma: Clinical Challenges and Targeting HuR as a Novel Therapeutic Strategy. | Livers | 2026 | 42583674 | PubTator, text mining | PubMed |
| SIRT6 Aggravates Psoriasiform Skin Inflammation Through Modulation of the SOCS2-STAT1/3 Pathway. | J Inflamm Res | 2026 | 42577923 | PubTator, text mining | PubMed |
| Single cell multi-omics enables high-resolution identification and functional purification of human acute myeloid leukemia stem cells. | bioRxiv | 2026 | 42523402 | PubTator, text mining | PubMed |
| Prognostic Relevance of Neddylation-Related Genes in Hepatocellular Carcinoma. | J Hepatocell Carcinoma | 2026 | 42460258 | PubTator, text mining | PubMed |
| Identification of circadian rhythm-associated key genes in metabolic dysfunction-associated fatty liver disease. | Clin Exp Med | 2026 | 42329455 | PubTator, text mining | PubMed |
| SOCS2 inhibits neutrophil N1 polarization to attenuate cardiomyocyte PANoptosis through HSPA8 ubiquitination in atrial fibrillation. | Biochem Biophys Res Commun | 2026 | 42251819 | PubTator, text mining | PubMed |
1 to 10 of 2,451
See all 2,451 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/8835
GET https://conductscience.org/api/genes/v1/8835/patents?page=2