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Gene · 8835

SOCS2: suppressor of cytokine signaling 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SOCS2: suppressor of cytokine signaling 2. Genes, record 8835. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8835

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Gene

Symbol
SOCS2
HGNC
Name
suppressor of cytokine signaling 2
HGNC
NCBI Gene ID
8835
NCBI Gene
HGNC ID
HGNC:19382
HGNC
Ensembl
ENSG00000120833
NCBI Gene
Aliases
CIS2, Cish2, SOCS-2, SSI-2, SSI2, STATI2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O14508Suppressor of cytokine signaling 219813Ensembl, GeneID, HGNC

Source UniProt

Patents112

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2025032204 A2025-03-1136224O14508Espacenet
JP 2025032204 A2025-03-1136225O14508Espacenet
JP 2025032204 A2025-03-1136226O14508Espacenet
JP 2025032204 A2025-03-1136228O14508Espacenet
JP 2025032204 A2025-03-1136231O14508Espacenet
JP 2025032204 A2025-03-1136235O14508Espacenet
EP 4461818 A22024-11-1336224O14508Espacenet
EP 4461818 A22024-11-1336225O14508Espacenet
EP 4461818 A22024-11-1336226O14508Espacenet
EP 4461818 A22024-11-1336228O14508Espacenet

1 to 10 of 112

See all 112 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,422

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSOCS2 papersNewest fiscal year
P30CA015704Cancer Center Support Grant42025
P30CA016058Cancer Center Support Grant42025
P30CA016086Cancer Center Support Grant42025
P30CA016672Cancer Center Support Grant42025
P30CA023074University of Arizona Cancer Center - Cancer Center Support Grant42025
P30CA051008Georgetown University Lombardi Comprehensive Cancer Center Support Grant42025
P30DK020572Michigan Diabetes Research Center (MDRC)42025
P30ES013508Center of Excellence in Environmental Toxicology42025
R01ES025530Role of AHR in Dendritic Cells in the Control of CNS Autoimmunity42025
P30AI027763UCSF-Bay Area Center for AIDS Research32025

1 to 10 of 1,422Source NIH's project files

See all 1,422 nih grants

Papers2,451

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
SOCS2 Downregulation Is Associated with a Ferro-Aging-Related Transcriptomic Signature in Proximal Tubular Cells in Chronic Kidney Disease.Biomedicines202642792788PubTator, text miningPubMed
Differential regulation of SOCS signalling and immunoproteasome pathways by JAK inhibitors and TNF inhibitors in rheumatoid arthritis.Arthritis Res Ther202642745343PubTator, text miningPubMed
Integrated Transcriptomic Analyses Identify Four Prognosis-Associated Genes in Hepatocellular Carcinoma.Int J Mol Sci202642737438PubTator, text miningPubMed
Extracellular Vesicles in Cardiovascular Disease: Intercellular Signaling, Liquid Biopsy Biomarkers, and Therapeutic Translation.Circ Res202642594169PubTator, text miningPubMed
Decoding the Complexity of Hepatocellular Carcinoma: Clinical Challenges and Targeting HuR as a Novel Therapeutic Strategy.Livers202642583674PubTator, text miningPubMed
SIRT6 Aggravates Psoriasiform Skin Inflammation Through Modulation of the SOCS2-STAT1/3 Pathway.J Inflamm Res202642577923PubTator, text miningPubMed
Single cell multi-omics enables high-resolution identification and functional purification of human acute myeloid leukemia stem cells.bioRxiv202642523402PubTator, text miningPubMed
Prognostic Relevance of Neddylation-Related Genes in Hepatocellular Carcinoma.J Hepatocell Carcinoma202642460258PubTator, text miningPubMed
Identification of circadian rhythm-associated key genes in metabolic dysfunction-associated fatty liver disease.Clin Exp Med202642329455PubTator, text miningPubMed
SOCS2 inhibits neutrophil N1 polarization to attenuate cardiomyocyte PANoptosis through HSPA8 ubiquitination in atrial fibrillation.Biochem Biophys Res Commun202642251819PubTator, text miningPubMed

1 to 10 of 2,451

See all 2,451 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/8835

GET https://conductscience.org/api/genes/v1/8835/patents?page=2