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Gene · 9101

USP8: ubiquitin specific peptidase 8

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. USP8: ubiquitin specific peptidase 8. Genes, record 9101. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9101

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Gene

Symbol
USP8
HGNC
Name
ubiquitin specific peptidase 8
HGNC
NCBI Gene ID
9101
NCBI Gene
HGNC ID
HGNC:12631
HGNC
Ensembl
ENSG00000138592
NCBI Gene
Aliases
HumORF8, KIAA0055, PITA4, SPG59, UBPY
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P40818Ubiquitin carboxyl-terminal hydrolase 81,1189Ensembl, GeneID, HGNC

Source UniProt

Patents32

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-194129P40818Espacenet
EP 4640849 A22025-10-29537P40818Espacenet
EP 4641201 A22025-10-293682P40818Espacenet
JP 2025519096 A2025-06-24537P40818Espacenet
JP 2025517969 A2025-06-123682P40818Espacenet
JP 2025517970 A2025-06-124129P40818Espacenet
JP 2023551068 A2023-12-0646P40818Espacenet
JP 2023549761 A2023-11-2946P40818Espacenet
JP 2023549167 A2023-11-2246P40818Espacenet
JP 2023548973 A2023-11-2146P40818Espacenet

1 to 10 of 32

See all 32 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants759

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleUSP8 papersNewest fiscal year
P30CA016672Cancer Center Support Grant62025
P30DK020572Michigan Diabetes Research Center (MDRC)62025
ZIANS003150Improved Diagnosis and Treatment of Cushing's Disease62025
R35GM118063Cell signaling in development and regeneration52025
P50CA211015UCLA SPORE in Brain Cancer42025
R01GM058202Ubiquitin-dependent sorting in endosomes and the TGN42025
ZIEHD008944Pediatric Endocrinology Training Program42025
P30CA008748Cancer Center Support Grant32025
R01CA251930Development of 3-dimensional human pituitary corticotroph tumor cultures as a preclinical model for drug discovery32025
R01GM147696Systematic stabilization of specific protein-protein interactions32025

1 to 10 of 759Source NIH's project files

See all 759 nih grants

Papers1,448

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Deubiquitinase USP8 inhibits HIV-1 replication by suppressing Tat-mediated viral transactivation.J Virol202642803586PubTator, text miningPubMed
Proteome-wide Mendelian randomization and transcriptome analysis of a novel osteoarthritis blood-targeting USP8, single-cell model and experimental validation.Int Immunopharmacol202642772042PubTator, text miningPubMed
Somatic genetic alterations in pituitary neuroendocrine tumors.Endocr Relat Cancer202642565462PubTator, text miningPubMed
USP8 promotes the progression of sepsis-induced acute lung injury by interacting with the USP24 to suppress PGC-1α deubiquitination and expression.Redox Biol202642537474PubTator, text miningPubMed
Targeting USP8 with odoroside A regulates LXRβ-mediated fatty acid metabolic reprogramming against colorectal cancer.Acta Pharmacol Sin202642420594PubTator, text miningPubMed
Targeting SLK protects against cerebral ischemia-reperfusion injury by regulating USP8-mediated HIF-1α stabilization and RhoA/ROCK activation.Cell Mol Biol Lett202642387373PubTator, text miningPubMed
Sbno1 and Usp8 Cooperate to Enhance Notch Signaling in Regulating Neural Stem Cells.Dev Growth Differ202642323189PubTator, text miningPubMed
Distinct genetic alterations drive Cushing disease vs silent corticotroph adenomas.J Clin Endocrinol Metab202642273717PubTator, text miningPubMed
Molecular profile of Cushing's syndrome.Vitam Horm202642236012PubTator, text miningPubMed
Real-time PCR-based intraoperative molecular boundary diagnosis of corticotroph pituitary neuroendocrine tumors.J Neurosci Methods202642214473PubTator, text miningPubMed

1 to 10 of 1,448

See all 1,448 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/9101

GET https://conductscience.org/api/genes/v1/9101/patents?page=2