Gene · 9101
USP8: ubiquitin specific peptidase 8
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. USP8: ubiquitin specific peptidase 8. Genes, record 9101. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9101
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P40818 | Ubiquitin carboxyl-terminal hydrolase 8 | 1,118 | 9 | Ensembl, GeneID, HGNC |
Source UniProt
Patents32
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 4129 | P40818 | Espacenet |
| EP 4640849 A2 | 2025-10-29 | 537 | P40818 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 3682 | P40818 | Espacenet |
| JP 2025519096 A | 2025-06-24 | 537 | P40818 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 3682 | P40818 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 4129 | P40818 | Espacenet |
| JP 2023551068 A | 2023-12-06 | 46 | P40818 | Espacenet |
| JP 2023549761 A | 2023-11-29 | 46 | P40818 | Espacenet |
| JP 2023549167 A | 2023-11-22 | 46 | P40818 | Espacenet |
| JP 2023548973 A | 2023-11-21 | 46 | P40818 | Espacenet |
1 to 10 of 32
See all 32 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants759
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | USP8 papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 6 | 2025 |
| P30DK020572 | Michigan Diabetes Research Center (MDRC) | 6 | 2025 |
| ZIANS003150 | Improved Diagnosis and Treatment of Cushing's Disease | 6 | 2025 |
| R35GM118063 | Cell signaling in development and regeneration | 5 | 2025 |
| P50CA211015 | UCLA SPORE in Brain Cancer | 4 | 2025 |
| R01GM058202 | Ubiquitin-dependent sorting in endosomes and the TGN | 4 | 2025 |
| ZIEHD008944 | Pediatric Endocrinology Training Program | 4 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 3 | 2025 |
| R01CA251930 | Development of 3-dimensional human pituitary corticotroph tumor cultures as a preclinical model for drug discovery | 3 | 2025 |
| R01GM147696 | Systematic stabilization of specific protein-protein interactions | 3 | 2025 |
1 to 10 of 759Source NIH's project files
See all 759 nih grantsPapers1,448
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Deubiquitinase USP8 inhibits HIV-1 replication by suppressing Tat-mediated viral transactivation. | J Virol | 2026 | 42803586 | PubTator, text mining | PubMed |
| Proteome-wide Mendelian randomization and transcriptome analysis of a novel osteoarthritis blood-targeting USP8, single-cell model and experimental validation. | Int Immunopharmacol | 2026 | 42772042 | PubTator, text mining | PubMed |
| Somatic genetic alterations in pituitary neuroendocrine tumors. | Endocr Relat Cancer | 2026 | 42565462 | PubTator, text mining | PubMed |
| USP8 promotes the progression of sepsis-induced acute lung injury by interacting with the USP24 to suppress PGC-1α deubiquitination and expression. | Redox Biol | 2026 | 42537474 | PubTator, text mining | PubMed |
| Targeting USP8 with odoroside A regulates LXRβ-mediated fatty acid metabolic reprogramming against colorectal cancer. | Acta Pharmacol Sin | 2026 | 42420594 | PubTator, text mining | PubMed |
| Targeting SLK protects against cerebral ischemia-reperfusion injury by regulating USP8-mediated HIF-1α stabilization and RhoA/ROCK activation. | Cell Mol Biol Lett | 2026 | 42387373 | PubTator, text mining | PubMed |
| Sbno1 and Usp8 Cooperate to Enhance Notch Signaling in Regulating Neural Stem Cells. | Dev Growth Differ | 2026 | 42323189 | PubTator, text mining | PubMed |
| Distinct genetic alterations drive Cushing disease vs silent corticotroph adenomas. | J Clin Endocrinol Metab | 2026 | 42273717 | PubTator, text mining | PubMed |
| Molecular profile of Cushing's syndrome. | Vitam Horm | 2026 | 42236012 | PubTator, text mining | PubMed |
| Real-time PCR-based intraoperative molecular boundary diagnosis of corticotroph pituitary neuroendocrine tumors. | J Neurosci Methods | 2026 | 42214473 | PubTator, text mining | PubMed |
1 to 10 of 1,448
See all 1,448 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/9101
GET https://conductscience.org/api/genes/v1/9101/patents?page=2