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Gene · 9113

LATS1: large tumor suppressor kinase 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. LATS1: large tumor suppressor kinase 1. Genes, record 9113. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9113

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Gene

Symbol
LATS1
HGNC
Name
large tumor suppressor kinase 1
HGNC
NCBI Gene ID
9113
NCBI Gene
HGNC ID
HGNC:6514
HGNC
Ensembl
ENSG00000131023
NCBI Gene
Aliases
WARTS, wts
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O95835Serine/threonine-protein kinase LATS11,1304Ensembl, GeneID, HGNC

Source UniProt

Patents52

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-191447O95835Espacenet
EP 4641201 A22025-10-291068O95835Espacenet
JP 2025532979 A2025-10-03106O95835Espacenet
EP 4593850 A22025-08-06106O95835Espacenet
JP 2025517969 A2025-06-121068O95835Espacenet
JP 2025517970 A2025-06-121447O95835Espacenet
US 12295971 B22025-05-13106O95835Espacenet
US 12268704 B22025-04-082O95835Espacenet
JP 2024123008 A2024-09-106796O95835Espacenet
JP 2024123008 A2024-09-106798O95835Espacenet

1 to 10 of 52

See all 52 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,633

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleLATS1 papersNewest fiscal year
P30CA016672Cancer Center Support Grant262025
P30CA008748Cancer Center Support Grant232025
R01EY015708Control of Cell Number in Developing Retina152025
R01GM126048Regulation and function of the Hippo pathway in growth control72025
P30CA016056Roswell Park Cancer Center Support Grant62025
P30CA051008Georgetown University Lombardi Comprehensive Cancer Center Support Grant62025
P01AG029531The Aging Pituitary/Gonadal Axis52025
P30CA014051Cancer Center Support (Core) Grant52025
R01HL118761Pitx2 in atrial fibrillation52025
R01NS034783Function of NF2/Merlin in regulation of the Hippo/Salvador/Warts growth control pathway52025

1 to 10 of 1,633Source NIH's project files

See all 1,633 nih grants

Papers3,081

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Melatonin ameliorates diabetic retinopathy by inhibiting PANoptosis via the LncSNHG5/miR-26a-5p/Hippo signaling axis.J Pharmacol Sci202642810779PubTator, text miningPubMed
Down-regulation of RhoA inhibits YAP by activating Hippo signaling to promote macrophage M1 polarization and enhance its phagocytosis, thereby inhibiting AML progression in preclinical models.Mol Cell Probes202642790655PubTator, text miningPubMed
Identification of candidate variants in plasma associated with early versus late disease progression under anti-PD-1 therapy in metastatic NSCLC.Transl Lung Cancer Res202642723788PubTator, text miningPubMed
Upstream Regulation of the Hippo Pathway.Cold Spring Harb Perspect Biol202642697693PubTator, text miningPubMed
Epitranscriptomic silencing of STK25 promotes ferroptosis evasion via the METTL3-YAP-GPX4 axis in osteosarcoma.Cancer Lett202642679917PubTator, text miningPubMed
LATS1/2 inactivation drives a distinct venous endothelial cell response that contributes to fibrotic remodeling of the lung.Sci Adv202642664350PubTator, text miningPubMed
Yorkie/YAP Interactors: Fine-Tuning the Hippo Pathway Output.Cold Spring Harb Perspect Biol202642575696PubTator, text miningPubMed
LINC00673-V4 Promotes Colorectal Cancer Cell Proliferation by Interacting With FUS and Restoring the Expression of Hippo-YAP Target Genes.Front Biosci (Landmark Ed)202642530263PubTator, text miningPubMed
Alteration in the Yap Signaling Pathway in Cataractous Human Lens Epithelium.Curr Eye Res202642494054PubTator, text miningPubMed
Targeting Sirtuins in Thyroid Cancer: Mechanisms, Drug Development, and Emerging Roles in Tumor Immunity and Ferroptosis.Cancers (Basel)202642449637PubTator, text miningPubMed

1 to 10 of 3,081

See all 3,081 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/9113

GET https://conductscience.org/api/genes/v1/9113/patents?page=2