Gene · 9113
LATS1: large tumor suppressor kinase 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. LATS1: large tumor suppressor kinase 1. Genes, record 9113. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9113
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O95835 | Serine/threonine-protein kinase LATS1 | 1,130 | 4 | Ensembl, GeneID, HGNC |
Source UniProt
Patents52
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 1447 | O95835 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 1068 | O95835 | Espacenet |
| JP 2025532979 A | 2025-10-03 | 106 | O95835 | Espacenet |
| EP 4593850 A2 | 2025-08-06 | 106 | O95835 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 1068 | O95835 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 1447 | O95835 | Espacenet |
| US 12295971 B2 | 2025-05-13 | 106 | O95835 | Espacenet |
| US 12268704 B2 | 2025-04-08 | 2 | O95835 | Espacenet |
| JP 2024123008 A | 2024-09-10 | 6796 | O95835 | Espacenet |
| JP 2024123008 A | 2024-09-10 | 6798 | O95835 | Espacenet |
1 to 10 of 52
See all 52 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,633
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | LATS1 papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 26 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 23 | 2025 |
| R01EY015708 | Control of Cell Number in Developing Retina | 15 | 2025 |
| R01GM126048 | Regulation and function of the Hippo pathway in growth control | 7 | 2025 |
| P30CA016056 | Roswell Park Cancer Center Support Grant | 6 | 2025 |
| P30CA051008 | Georgetown University Lombardi Comprehensive Cancer Center Support Grant | 6 | 2025 |
| P01AG029531 | The Aging Pituitary/Gonadal Axis | 5 | 2025 |
| P30CA014051 | Cancer Center Support (Core) Grant | 5 | 2025 |
| R01HL118761 | Pitx2 in atrial fibrillation | 5 | 2025 |
| R01NS034783 | Function of NF2/Merlin in regulation of the Hippo/Salvador/Warts growth control pathway | 5 | 2025 |
1 to 10 of 1,633Source NIH's project files
See all 1,633 nih grantsPapers3,081
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Melatonin ameliorates diabetic retinopathy by inhibiting PANoptosis via the LncSNHG5/miR-26a-5p/Hippo signaling axis. | J Pharmacol Sci | 2026 | 42810779 | PubTator, text mining | PubMed |
| Down-regulation of RhoA inhibits YAP by activating Hippo signaling to promote macrophage M1 polarization and enhance its phagocytosis, thereby inhibiting AML progression in preclinical models. | Mol Cell Probes | 2026 | 42790655 | PubTator, text mining | PubMed |
| Identification of candidate variants in plasma associated with early versus late disease progression under anti-PD-1 therapy in metastatic NSCLC. | Transl Lung Cancer Res | 2026 | 42723788 | PubTator, text mining | PubMed |
| Upstream Regulation of the Hippo Pathway. | Cold Spring Harb Perspect Biol | 2026 | 42697693 | PubTator, text mining | PubMed |
| Epitranscriptomic silencing of STK25 promotes ferroptosis evasion via the METTL3-YAP-GPX4 axis in osteosarcoma. | Cancer Lett | 2026 | 42679917 | PubTator, text mining | PubMed |
| LATS1/2 inactivation drives a distinct venous endothelial cell response that contributes to fibrotic remodeling of the lung. | Sci Adv | 2026 | 42664350 | PubTator, text mining | PubMed |
| Yorkie/YAP Interactors: Fine-Tuning the Hippo Pathway Output. | Cold Spring Harb Perspect Biol | 2026 | 42575696 | PubTator, text mining | PubMed |
| LINC00673-V4 Promotes Colorectal Cancer Cell Proliferation by Interacting With FUS and Restoring the Expression of Hippo-YAP Target Genes. | Front Biosci (Landmark Ed) | 2026 | 42530263 | PubTator, text mining | PubMed |
| Alteration in the Yap Signaling Pathway in Cataractous Human Lens Epithelium. | Curr Eye Res | 2026 | 42494054 | PubTator, text mining | PubMed |
| Targeting Sirtuins in Thyroid Cancer: Mechanisms, Drug Development, and Emerging Roles in Tumor Immunity and Ferroptosis. | Cancers (Basel) | 2026 | 42449637 | PubTator, text mining | PubMed |
1 to 10 of 3,081
See all 3,081 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/9113
GET https://conductscience.org/api/genes/v1/9113/patents?page=2