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Gene · 9180

OSMR: oncostatin M receptor

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. OSMR: oncostatin M receptor. Genes, record 9180. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9180

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Gene

Symbol
OSMR
HGNC
Name
oncostatin M receptor
HGNC
NCBI Gene ID
9180
NCBI Gene
HGNC ID
HGNC:8507
HGNC
Ensembl
ENSG00000145623
NCBI Gene
Aliases
IL-31R-beta, IL-31RB, OSMRB, OSMRbeta, PLCA1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q99650Oncostatin-M-specific receptor subunit beta9790Ensembl, GeneID, HGNC

Source UniProt

Patents157

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1456531Q99650Espacenet
EP 4650780 A22025-11-192896Q99650Espacenet
EP 4640849 A22025-10-29358Q99650Espacenet
EP 4641201 A22025-10-292461Q99650Espacenet
JP 2025147176 A2025-10-069857Q99650Espacenet
JP 2025147176 A2025-10-0616772Q99650Espacenet
JP 2025529142 A2025-09-043300Q99650Espacenet
JP 2025529142 A2025-09-047241Q99650Espacenet
JP 2025114801 A2025-08-051Q99650Espacenet
US 12371689 B22025-07-293300Q99650Espacenet

1 to 10 of 157

See all 157 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
VIXARELIMABCHEMBL4594341Oncostatin-M-specific receptor subunit beta inhibitorINHIBITOR

Source ChEMBL

Trials5

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06693908VIXARELIMABPHASE1/PHASE2ClinicalTrials.gov
NCT06137183VIXARELIMABPHASE22026-02-24ClinicalTrials.gov
NCT05785624VIXARELIMABPHASE2ClinicalTrials.gov
NCT03858634VIXARELIMABPHASE22021-12-28ClinicalTrials.gov
NCT03816891VIXARELIMABPHASE22026-01-13ClinicalTrials.gov

NIH grants973

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleOSMR papersNewest fiscal year
P20GM103408Idaho INBRE Program122025
P30CA016056Roswell Park Cancer Center Support Grant72025
P30CA016672Cancer Center Support Grant72025
T32CA059366Cancer Biology Training Grant62025
P30CA034196Cancer Center Support (CORE) Grant32025
P30CA043703Case Comprehensive Cancer Center Support Grant32025
P30DK043351Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital32025
R01AI051321Structure-based engineering of immune cytokine signaling32025
U01DK062422Mount Sinai NYC Genetics Research Center: Multi-omic integration across data-types, cell niches and populations32025
UL1TR001863Yale Clinical and Translational Science Award32025

1 to 10 of 973Source NIH's project files

See all 973 nih grants

Papers1,423

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Lipid Metabolic Dysregulation Driven by OSMR Mutations Underlies Amyloidogenesis in Primary Localized Cutaneous Amyloidosis.Adv Sci (Weinh)202642811488PubTator, text miningPubMed
The Role of the OSM/OSMRβ Axis in Chronic Liver Disease Progression and Hepatocellular Carcinoma Development: A Focus on MASLD/MASH.Int J Mol Sci202642794644PubTator, text miningPubMed
Oncostatin M as a Multifunctional Regulator of Breast Cancer Progression: Current Insights and Future Therapeutic Avenues.IUBMB Life202642746957PubTator, text miningPubMed
: Interleukin-31 in Atopic Dermatitis and Prurigo Nodularis: Pathophysiology, Neuroimmune Mechanisms, and Clinical Efficacy of Nemolizumab.J Drugs Dermatol202642696343PubTator, text miningPubMed
Identification of Glioblastoma Cell Surface Proteins and Assessment of Their Expression Across Patient-Derived Stem-Like Cell Cultures.J Proteome Res202642695909PubTator, text miningPubMed
Tape Strip Transcriptomics Reveal Nemolizumab Effects on Pruritus, Hyperplasia, Inflammation, and Extracellular Matrix Markers in Patients With Moderate-to-Severe Atopic Dermatitis.Allergy202642693785PubTator, text miningPubMed
Autosomal recessive OSMRβ deficiency: Connecting OSM and/or IL-31 with atopy.J Hum Immun202642639505PubTator, text miningPubMed
Cryo-EM structure of the interleukin-31 receptor complex defines non-canonical interactions that confer receptor specificity.J Biol Chem202642637078PubTator, text miningPubMed
KLF4 in Smooth Muscle Cell-Derived Progenitor Cells Is Essential for Angiotensin II-Induced Cardiac Inflammation and Fibrosis.Arterioscler Thromb Vasc Biol202642619593PubTator, text miningPubMed
Longitudinal transcriptomic analysis of mucosa in ulcerative colitis after anti-tumor necrosis factor withdrawal compared to continued treatment.J Crohns Colitis202642586604PubTator, text miningPubMed

1 to 10 of 1,423

See all 1,423 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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