Gene · 92
ACVR2A: activin A receptor type 2A
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. ACVR2A: activin A receptor type 2A. Genes, record 92. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/92
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P27037 | Activin receptor type-2A | 513 | 5 | Ensembl, GeneID, HGNC |
Source UniProt
Patents302
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4825976 A2 | 2026-10-21 | 75 | P27037 | Espacenet |
| EP 4820042 A1 | 2026-10-14 | 9 | P27037 | Espacenet |
| EP 4820043 A1 | 2026-10-14 | 75 | P27037 | Espacenet |
| JP 2026123100 A | 2026-07-29 | 1 | P27037 | Espacenet |
| JP 2026120676 A | 2026-07-22 | 1 | P27037 | Espacenet |
| JP 2026068014 A | 2026-04-21 | 75 | P27037 | Espacenet |
| JP 2026026172 A | 2026-02-16 | 9 | P27037 | Espacenet |
| EP 4676515 A1 | 2026-01-14 | 9 | P27037 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 36242 | P27037 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 36243 | P27037 | Espacenet |
1 to 10 of 302
See all 302 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| DIBOTERMIN ALFA | CHEMBL2109171 | Activin receptor type-2A agonist | AGONIST |
Source ChEMBL
Trials1
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted |
|---|---|---|---|
| NCT05911477 | DIBOTERMIN ALFA |
Source ClinicalTrials.gov
NIH grants1,210
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | ACVR2A papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 10 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 10 | 2025 |
| P30CA054174 | Mays Cancer Center at UT Health SA | 6 | 2025 |
| P30CA014089 | University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG) | 5 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 5 | 2025 |
| R01HD032067 | Transforming growth factor β family signaling pathways in ovarian and uterine biology | 5 | 2025 |
| R01AA023146 | Role of Beta Spectrin and Smad in Alcohol-Induced Liver and GI Cell Proliferation | 4 | 2025 |
| P30CA006927 | Comprehensive Cancer Center Program at Fox Chase | 3 | 2025 |
| P30CA015704 | Cancer Center Support Grant | 3 | 2025 |
| P30CA016056 | Roswell Park Cancer Center Support Grant | 3 | 2025 |
1 to 10 of 1,210Source NIH's project files
See all 1,210 nih grantsPapers1,751
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Discovery of Fisetin as a potent and cell-active ACVR2A inhibitor. | Bioorg Med Chem Lett | 2027 | 42801961 | PubTator, text mining | PubMed |
| Activins and BMPs: The yin and yang of diffuse midline gliomas. | Cell Stem Cell | 2026 | 42822433 | PubTator, text mining | PubMed |
| Physiological Aging and Cardiovascular Disease Distinctly Remodel the Human Cardiac Lymphatic Endothelium. | bioRxiv | 2026 | 42818248 | PubTator, text mining | PubMed |
| GDF3 is an endogenous antagonist of the ActE-ALK7/ACVR2 pathway in adipocytes. | bioRxiv | 2026 | 42818110 | PubTator, text mining | PubMed |
| Whole-Exome Sequencing Identifies Candidate Genomic Features Associated with Response to Platinum-Based Chemotherapy and Ixabepilone-Based Treatment in Ovarian Cancer. | Int J Mol Sci | 2026 | 42737428 | PubTator, text mining | PubMed |
| Activin Signaling Inhibitors in Pulmonary Hypertension: A State-of-the-Art Review. | Pulm Circ | 2026 | 42516684 | PubTator, text mining | PubMed |
| Etiology-Driven Mouse Models of Hepatocellular Carcinoma: Paving the Way for Precision Oncology. | J Hepatocell Carcinoma | 2026 | 42438783 | PubTator, text mining | PubMed |
| Myostatin Signaling in Skeletal Muscle: Implications for Athletic Performance. | Compr Physiol | 2026 | 42322019 | PubTator, text mining | PubMed |
| Evaluation of Droplet Digital PCR Assay for the Detection of Microsatellite Instability in Colorectal, Gastric, and Endometrial Cancers. | Diagnostics (Basel) | 2026 | 42196916 | PubTator, text mining | PubMed |
| Molecular landscape and biomarker associations of functional NTRK fusions: a real-world retrospective cohort study across solid tumors. | Transl Cancer Res | 2026 | 41969448 | PubTator, text mining | PubMed |
1 to 10 of 1,751
See all 1,751 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/92
GET https://conductscience.org/api/genes/v1/92/patents?page=2