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Gene · 92

ACVR2A: activin A receptor type 2A

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ACVR2A: activin A receptor type 2A. Genes, record 92. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/92

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Gene

Symbol
ACVR2A
HGNC
Name
activin A receptor type 2A
HGNC
NCBI Gene ID
92
NCBI Gene
HGNC ID
HGNC:173
HGNC
Ensembl
ENSG00000121989
NCBI Gene
Aliases
ACTRII, ACVR2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P27037Activin receptor type-2A5135Ensembl, GeneID, HGNC

Source UniProt

Patents302

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4825976 A22026-10-2175P27037Espacenet
EP 4820042 A12026-10-149P27037Espacenet
EP 4820043 A12026-10-1475P27037Espacenet
JP 2026123100 A2026-07-291P27037Espacenet
JP 2026120676 A2026-07-221P27037Espacenet
JP 2026068014 A2026-04-2175P27037Espacenet
JP 2026026172 A2026-02-169P27037Espacenet
EP 4676515 A12026-01-149P27037Espacenet
JP 2026004568 A2026-01-1436242P27037Espacenet
JP 2026004568 A2026-01-1436243P27037Espacenet

1 to 10 of 302

See all 302 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
DIBOTERMIN ALFACHEMBL2109171Activin receptor type-2A agonistAGONIST

Source ChEMBL

Trials1

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first posted
NCT05911477DIBOTERMIN ALFA

NIH grants1,210

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleACVR2A papersNewest fiscal year
P30CA008748Cancer Center Support Grant102025
P30CA016672Cancer Center Support Grant102025
P30CA054174Mays Cancer Center at UT Health SA62025
P30CA014089University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)52025
P30CA068485Cancer Center Support Grant52025
R01HD032067Transforming growth factor β family signaling pathways in ovarian and uterine biology52025
R01AA023146Role of Beta Spectrin and Smad in Alcohol-Induced Liver and GI Cell Proliferation42025
P30CA006927Comprehensive Cancer Center Program at Fox Chase32025
P30CA015704Cancer Center Support Grant32025
P30CA016056Roswell Park Cancer Center Support Grant32025

1 to 10 of 1,210Source NIH's project files

See all 1,210 nih grants

Papers1,751

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Discovery of Fisetin as a potent and cell-active ACVR2A inhibitor.Bioorg Med Chem Lett202742801961PubTator, text miningPubMed
Activins and BMPs: The yin and yang of diffuse midline gliomas.Cell Stem Cell202642822433PubTator, text miningPubMed
Physiological Aging and Cardiovascular Disease Distinctly Remodel the Human Cardiac Lymphatic Endothelium.bioRxiv202642818248PubTator, text miningPubMed
GDF3 is an endogenous antagonist of the ActE-ALK7/ACVR2 pathway in adipocytes.bioRxiv202642818110PubTator, text miningPubMed
Whole-Exome Sequencing Identifies Candidate Genomic Features Associated with Response to Platinum-Based Chemotherapy and Ixabepilone-Based Treatment in Ovarian Cancer.Int J Mol Sci202642737428PubTator, text miningPubMed
Activin Signaling Inhibitors in Pulmonary Hypertension: A State-of-the-Art Review.Pulm Circ202642516684PubTator, text miningPubMed
Etiology-Driven Mouse Models of Hepatocellular Carcinoma: Paving the Way for Precision Oncology.J Hepatocell Carcinoma202642438783PubTator, text miningPubMed
Myostatin Signaling in Skeletal Muscle: Implications for Athletic Performance.Compr Physiol202642322019PubTator, text miningPubMed
Evaluation of Droplet Digital PCR Assay for the Detection of Microsatellite Instability in Colorectal, Gastric, and Endometrial Cancers.Diagnostics (Basel)202642196916PubTator, text miningPubMed
Molecular landscape and biomarker associations of functional NTRK fusions: a real-world retrospective cohort study across solid tumors.Transl Cancer Res202641969448PubTator, text miningPubMed

1 to 10 of 1,751

See all 1,751 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/92

GET https://conductscience.org/api/genes/v1/92/patents?page=2