Gene · 92140
MTDH: metadherin
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. MTDH: metadherin. Genes, record 92140. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/92140
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q86UE4 | Protein LYRIC | 582 | 1 | Ensembl, GeneID, HGNC |
Source UniProt
Patents35
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 6336 | Q86UE4 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 6099 | Q86UE4 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 2739 | Q86UE4 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 2739 | Q86UE4 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 6099 | Q86UE4 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 6336 | Q86UE4 | Espacenet |
| JP 2024123008 A | 2024-09-10 | 6961 | Q86UE4 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 50603 | Q86UE4 | Espacenet |
| US 11400116 B2 | 2022-08-02 | 6561 | Q86UE4 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 153574 | Q86UE4 | Espacenet |
1 to 10 of 35
See all 35 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants792
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | MTDH papers | Newest fiscal year |
|---|---|---|---|
| R01DK107451 | The role of AEG-1 in NASH and NASH-HCC | 16 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 9 | 2025 |
| P30CA016059 | Massey Cancer Center - Cancer Center Support Grant | 7 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 6 | 2025 |
| P30CA006973 | Regional Oncology Research Center | 5 | 2025 |
| P30CA072720 | Cancer Center Support Grant | 5 | 2025 |
| P30CA086862 | Cancer Center Support Grant | 5 | 2025 |
| P30CA051008 | Georgetown University Lombardi Comprehensive Cancer Center Support Grant | 3 | 2025 |
| P30ES005605 | Environmental Health Sciences Research Center | 3 | 2025 |
| P30CA016058 | Cancer Center Support Grant | 2 | 2025 |
1 to 10 of 792Source NIH's project files
See all 792 nih grantsPapers2,305
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Integrated roles of miR-125b, miR-375, and miR-451 in breast cancer chemoresistance: mechanistic insights and translational implications. | Mol Biol Rep | 2026 | 42684565 | PubTator, text mining | PubMed |
| USP14 competitively binds to FBXW7 to stabilize MTDH and promotes metastasis and drug resistance of head and neck squamous cell carcinoma. | Proc Natl Acad Sci U S A | 2026 | 42616774 | PubTator, text mining | PubMed |
| AEG-1/MTDH: A central regulator of tumor progression, metabolic adaptation, and therapeutic resistance in gliomas. | Tissue Cell | 2026 | 42570368 | PubTator, text mining | PubMed |
| Molecular Pathophysiology of Hepatocellular Carcinoma: From Metabolic Inflammation to Therapeutic Targets. | Cancers (Basel) | 2026 | 42512398 | PubTator, text mining | PubMed |
| Structure-guided identification of 2-arylbenzothiazoles as disruptors of the oncogenic MTDH-SND1 protein-protein interaction. | Arch Biochem Biophys | 2026 | 42498240 | PubTator, text mining | PubMed |
| Recent advances in immunotherapy for breast cancer: An updated review. | Crit Rev Oncol Hematol | 2026 | 42480964 | PubTator, text mining | PubMed |
| Beyond VEGF: AEG-1/MTDH as a Systems-Level Orchestrator of Angiogenesis in Hepatocellular Carcinoma. | Cells | 2026 | 42439688 | PubTator, text mining | PubMed |
| Structure-Based Discovery of N-Aryl-N'-Heteroaryl Ureas as Disruptors of the Oncogenic MTDH-SND1 Protein-Protein Interaction: In Silico Insights and Biochemical Validation. | Arch Pharm (Weinheim) | 2026 | 42397067 | PubTator, text mining | PubMed |
| CAF-derived extracellular vesicle-associated LINC02420 links stromal communication to HIF1A-dependent glycolytic regulation in head and neck cancer. | Cancer Lett | 2026 | 42296563 | PubTator, text mining | PubMed |
| Metadherin: A pivotal oncogene and therapeutic target in head and neck cancer - a systematic review. | Jpn Dent Sci Rev | 2026 | 42294496 | PubTator, text mining | PubMed |
1 to 10 of 2,305
See all 2,305 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/92140
GET https://conductscience.org/api/genes/v1/92140/patents?page=2