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Gene · 92140

MTDH: metadherin

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. MTDH: metadherin. Genes, record 92140. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/92140

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Gene

Symbol
MTDH
HGNC
Name
metadherin
HGNC
NCBI Gene ID
92140
NCBI Gene
HGNC ID
HGNC:29608
HGNC
Ensembl
ENSG00000147649
NCBI Gene
Aliases
3D3, AEG-1, AEG1, LYRIC, LYRIC/3D3
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q86UE4Protein LYRIC5821Ensembl, GeneID, HGNC

Source UniProt

Patents35

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-196336Q86UE4Espacenet
EP 4641201 A22025-10-296099Q86UE4Espacenet
JP 2025529142 A2025-09-042739Q86UE4Espacenet
US 12371689 B22025-07-292739Q86UE4Espacenet
JP 2025517969 A2025-06-126099Q86UE4Espacenet
JP 2025517970 A2025-06-126336Q86UE4Espacenet
JP 2024123008 A2024-09-106961Q86UE4Espacenet
US 11446398 B22022-09-2050603Q86UE4Espacenet
US 11400116 B22022-08-026561Q86UE4Espacenet
JP 2022524081 A2022-04-27153574Q86UE4Espacenet

1 to 10 of 35

See all 35 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants792

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMTDH papersNewest fiscal year
R01DK107451The role of AEG-1 in NASH and NASH-HCC162025
P30CA016672Cancer Center Support Grant92025
P30CA016059Massey Cancer Center - Cancer Center Support Grant72025
P30CA008748Cancer Center Support Grant62025
P30CA006973Regional Oncology Research Center52025
P30CA072720Cancer Center Support Grant52025
P30CA086862Cancer Center Support Grant52025
P30CA051008Georgetown University Lombardi Comprehensive Cancer Center Support Grant32025
P30ES005605Environmental Health Sciences Research Center32025
P30CA016058Cancer Center Support Grant22025

1 to 10 of 792Source NIH's project files

See all 792 nih grants

Papers2,305

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Integrated roles of miR-125b, miR-375, and miR-451 in breast cancer chemoresistance: mechanistic insights and translational implications.Mol Biol Rep202642684565PubTator, text miningPubMed
USP14 competitively binds to FBXW7 to stabilize MTDH and promotes metastasis and drug resistance of head and neck squamous cell carcinoma.Proc Natl Acad Sci U S A202642616774PubTator, text miningPubMed
AEG-1/MTDH: A central regulator of tumor progression, metabolic adaptation, and therapeutic resistance in gliomas.Tissue Cell202642570368PubTator, text miningPubMed
Molecular Pathophysiology of Hepatocellular Carcinoma: From Metabolic Inflammation to Therapeutic Targets.Cancers (Basel)202642512398PubTator, text miningPubMed
Structure-guided identification of 2-arylbenzothiazoles as disruptors of the oncogenic MTDH-SND1 protein-protein interaction.Arch Biochem Biophys202642498240PubTator, text miningPubMed
Recent advances in immunotherapy for breast cancer: An updated review.Crit Rev Oncol Hematol202642480964PubTator, text miningPubMed
Beyond VEGF: AEG-1/MTDH as a Systems-Level Orchestrator of Angiogenesis in Hepatocellular Carcinoma.Cells202642439688PubTator, text miningPubMed
Structure-Based Discovery of N-Aryl-N'-Heteroaryl Ureas as Disruptors of the Oncogenic MTDH-SND1 Protein-Protein Interaction: In Silico Insights and Biochemical Validation.Arch Pharm (Weinheim)202642397067PubTator, text miningPubMed
CAF-derived extracellular vesicle-associated LINC02420 links stromal communication to HIF1A-dependent glycolytic regulation in head and neck cancer.Cancer Lett202642296563PubTator, text miningPubMed
Metadherin: A pivotal oncogene and therapeutic target in head and neck cancer - a systematic review.Jpn Dent Sci Rev202642294496PubTator, text miningPubMed

1 to 10 of 2,305

See all 2,305 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/92140

GET https://conductscience.org/api/genes/v1/92140/patents?page=2