Gene · 9217
VAPB: VAMP associated protein B and C
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. VAPB: VAMP associated protein B and C. Genes, record 9217. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9217
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O95292 | Vesicle-associated membrane protein-associated protein B/C | 243 | 2 | Ensembl, GeneID, HGNC |
Source UniProt
Patents182
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026090543 A | 2026-06-02 | 30 | O95292 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 69563 | O95292 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 14061 | O95292 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 5223 | O95292 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 5223 | O95292 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 14061 | O95292 | Espacenet |
| JP 2024523001 A | 2024-06-25 | 525 | O95292 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 96395 | O95292 | Espacenet |
| US 11400116 B2 | 2022-08-02 | 3114 | O95292 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 199366 | O95292 | Espacenet |
1 to 10 of 182
See all 182 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants969
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | VAPB papers | Newest fiscal year |
|---|---|---|---|
| P30DA018343 | Yale/NIDA Neuroproteomics Center | 12 | 2025 |
| P30DK045735 | Yale Diabetes Research Center | 10 | 2025 |
| ZIAAG000933 | Genetic etiology of Amyotrophic Lateral Sclerosis | 6 | 2025 |
| P40OD018537 | Bloomington Drosophila Stock Center at Indiana University | 4 | 2025 |
| P01AG019724 | Frontotemporal Dementia: Genes, Images, and Emotions | 3 | 2025 |
| P30CA091842 | Cancer Center Support Grant | 3 | 2025 |
| P40OD010440 | Caenorhabditis Genetics Center | 3 | 2025 |
| R01AG011085 | Ubiquitin‐mediated proteolysis and cell cycle control | 3 | 2025 |
| U54NS092091 | Clinical Research in ALS and Related Disorders for Therapeutic Development (CReATe) | 3 | 2025 |
| ZIAHD001607 | Protein Trafficking In The Endosomal-Lysosomal System | 3 | 2025 |
1 to 10 of 969Source NIH's project files
See all 969 nih grantsPapers1,571
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Neuro-glial lipid imbalance in a Drosophila model of amyotrophic lateral sclerosis 8. | Acta Neuropathol Commun | 2026 | 42760536 | PubTator, text mining | PubMed |
| Sigma-1 Receptor Stimulation Rescues FTD/ALS Mutant TDP43-Induced Disruption of the VAPB-PTPIP51 ER-Mitochondria Tethering Proteins via Inhibition of GSK3β. | Cells | 2026 | 42738830 | PubTator, text mining | PubMed |
| Phosphorylation-dependent interaction between VAP proteins and INF2 influences ER morphology. | Curr Biol | 2026 | 42710492 | PubTator, text mining | PubMed |
| Glial ceramide orchestrates lipid homeostasis and age-dependent motor function. | Dis Model Mech | 2026 | 42634871 | PubTator, text mining | PubMed |
| Genetic profile of motor neuron disease in a multiregional Brazilian cohort: an 18-year real-world experience in 1,911 patients. | Front Neurol | 2026 | 42621206 | PubTator, text mining | PubMed |
| Impaired Endothelial Cell Cholesterol Metabolism Promotes Vascular Inflammation in Sleep Apnea. | Circ Res | 2026 | 42375116 | PubTator, text mining | PubMed |
| VAPB confers selective neuroprotection by driving autophagic degradation of pathogenic aggregates in ALS. | Acta Neuropathol Commun | 2026 | 42210413 | PubTator, text mining | PubMed |
| Clinical characterization and natural history of ALS8/VAPB p.Pro56Ser: upper motor neurone signs, survival, and functional milestones in 78 patients. | Amyotroph Lateral Scler Frontotemporal Degener | 2026 | 42166520 | PubTator, text mining | PubMed |
| Kv2-VAP interactions enhance presynaptic ER and mitochondrial calcium influx and the mobilization of vesicles from the reserve pool. | bioRxiv | 2026 | 42146497 | PubTator, text mining | PubMed |
| Quantitative FRET FLIM imaging reveals multiple interactions between proteins of the ESYT, ORP, and VAP families at the endoplasmic reticulum membrane. | J Biol Chem | 2026 | 42134546 | PubTator, text mining | PubMed |
1 to 10 of 1,571
See all 1,571 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/9217
GET https://conductscience.org/api/genes/v1/9217/patents?page=2