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Gene · 9217

VAPB: VAMP associated protein B and C

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. VAPB: VAMP associated protein B and C. Genes, record 9217. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9217

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Gene

Symbol
VAPB
HGNC
Name
VAMP associated protein B and C
HGNC
NCBI Gene ID
9217
NCBI Gene
HGNC ID
HGNC:12649
HGNC
Ensembl
ENSG00000124164
NCBI Gene
Aliases
ALS8, VAMP-B, VAP-B, VAP-C
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O95292Vesicle-associated membrane protein-associated protein B/C2432Ensembl, GeneID, HGNC

Source UniProt

Patents182

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026090543 A2026-06-0230O95292Espacenet
JP 2026004568 A2026-01-1469563O95292Espacenet
EP 4650780 A22025-11-1914061O95292Espacenet
JP 2025529142 A2025-09-045223O95292Espacenet
US 12371689 B22025-07-295223O95292Espacenet
JP 2025517970 A2025-06-1214061O95292Espacenet
JP 2024523001 A2024-06-25525O95292Espacenet
US 11446398 B22022-09-2096395O95292Espacenet
US 11400116 B22022-08-023114O95292Espacenet
JP 2022524081 A2022-04-27199366O95292Espacenet

1 to 10 of 182

See all 182 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants969

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleVAPB papersNewest fiscal year
P30DA018343Yale/NIDA Neuroproteomics Center122025
P30DK045735Yale Diabetes Research Center102025
ZIAAG000933Genetic etiology of Amyotrophic Lateral Sclerosis62025
P40OD018537Bloomington Drosophila Stock Center at Indiana University42025
P01AG019724Frontotemporal Dementia: Genes, Images, and Emotions32025
P30CA091842Cancer Center Support Grant32025
P40OD010440Caenorhabditis Genetics Center32025
R01AG011085Ubiquitin‐mediated proteolysis and cell cycle control32025
U54NS092091Clinical Research in ALS and Related Disorders for Therapeutic Development (CReATe)32025
ZIAHD001607Protein Trafficking In The Endosomal-Lysosomal System32025

1 to 10 of 969Source NIH's project files

See all 969 nih grants

Papers1,571

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Neuro-glial lipid imbalance in a Drosophila model of amyotrophic lateral sclerosis 8.Acta Neuropathol Commun202642760536PubTator, text miningPubMed
Sigma-1 Receptor Stimulation Rescues FTD/ALS Mutant TDP43-Induced Disruption of the VAPB-PTPIP51 ER-Mitochondria Tethering Proteins via Inhibition of GSK3β.Cells202642738830PubTator, text miningPubMed
Phosphorylation-dependent interaction between VAP proteins and INF2 influences ER morphology.Curr Biol202642710492PubTator, text miningPubMed
Glial ceramide orchestrates lipid homeostasis and age-dependent motor function.Dis Model Mech202642634871PubTator, text miningPubMed
Genetic profile of motor neuron disease in a multiregional Brazilian cohort: an 18-year real-world experience in 1,911 patients.Front Neurol202642621206PubTator, text miningPubMed
Impaired Endothelial Cell Cholesterol Metabolism Promotes Vascular Inflammation in Sleep Apnea.Circ Res202642375116PubTator, text miningPubMed
VAPB confers selective neuroprotection by driving autophagic degradation of pathogenic aggregates in ALS.Acta Neuropathol Commun202642210413PubTator, text miningPubMed
Clinical characterization and natural history of ALS8/VAPB p.Pro56Ser: upper motor neurone signs, survival, and functional milestones in 78 patients.Amyotroph Lateral Scler Frontotemporal Degener202642166520PubTator, text miningPubMed
Kv2-VAP interactions enhance presynaptic ER and mitochondrial calcium influx and the mobilization of vesicles from the reserve pool.bioRxiv202642146497PubTator, text miningPubMed
Quantitative FRET FLIM imaging reveals multiple interactions between proteins of the ESYT, ORP, and VAP families at the endoplasmic reticulum membrane.J Biol Chem202642134546PubTator, text miningPubMed

1 to 10 of 1,571

See all 1,571 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/9217

GET https://conductscience.org/api/genes/v1/9217/patents?page=2