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Gene · 9294

S1PR2: sphingosine-1-phosphate receptor 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. S1PR2: sphingosine-1-phosphate receptor 2. Genes, record 9294. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9294

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Gene

Symbol
S1PR2
HGNC
Name
sphingosine-1-phosphate receptor 2
HGNC
NCBI Gene ID
9294
NCBI Gene
HGNC ID
HGNC:3169
HGNC
Ensembl
ENSG00000267534
NCBI Gene
Aliases
AGR16, DFNB68, EDG-5, EDG5, Gpcr13, H218, LPB2, S1P2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O95136Sphingosine 1-phosphate receptor 23532Ensembl, GeneID, HGNC

Source UniProt

Patents31

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1465285O95136Espacenet
EP 4650780 A22025-11-1919527O95136Espacenet
EP 4640849 A22025-10-294037O95136Espacenet
EP 4641201 A22025-10-2925134O95136Espacenet
JP 2025529142 A2025-09-043811O95136Espacenet
US 12371689 B22025-07-293811O95136Espacenet
JP 2025519096 A2025-06-244037O95136Espacenet
JP 2025517969 A2025-06-1225134O95136Espacenet
JP 2025517970 A2025-06-1219527O95136Espacenet
JP 2025024198 A2025-02-1916056O95136Espacenet

1 to 10 of 31

See all 31 patents

Drugs6

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AMISELIMODCHEMBL3707375Sphingosine 1-phosphate receptor modulatorMODULATORChEMBL
AMISELIMOD HYDROCHLORIDECHEMBL3707374Sphingosine 1-phosphate receptor modulatorMODULATORChEMBL
FINGOLIMODCHEMBL314854Sphingosine 1-phosphate receptor agonistAGONISTChEMBL
FINGOLIMODCHEMBL314854Sphingosine 1-phosphate receptor binding agentBINDING AGENTChEMBL
FINGOLIMOD HYDROCHLORIDECHEMBL544665Sphingosine 1-phosphate receptor agonistAGONISTChEMBL
FINGOLIMOD LAURYL SULFATECHEMBL5095050Sphingosine 1-phosphate receptor binding agentBINDING AGENTChEMBL

Trials83

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07483632FINGOLIMODPHASE3ClinicalTrials.gov
NCT07220252FINGOLIMODPHASE2/PHASE3ClinicalTrials.gov
NCT06424067FINGOLIMODPHASE2ClinicalTrials.gov
NCT06408259FINGOLIMODPHASE3ClinicalTrials.gov
NCT06087965FINGOLIMODPHASE1/PHASE2ClinicalTrials.gov
NCT05762003FINGOLIMODClinicalTrials.gov
NCT05423769FINGOLIMODClinicalTrials.gov
NCT05141669FINGOLIMODClinicalTrials.gov
NCT05123703FINGOLIMODPHASE3ClinicalTrials.gov
NCT04857112AMISELIMODPHASE2ClinicalTrials.gov

1 to 10 of 83

See all 83 trials

NIH grants1,282

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleS1PR2 papersNewest fiscal year
P01CA097132Sphingolipids in Cancer Biology and Therapy192025
P30CA016059Massey Cancer Center - Cancer Center Support Grant102025
IK6BX004477BLR&D Research Career Scientist Award Application72025
P30CA138313Medical University of South Carolina - Cancer Center Support Grant72025
P01HL126609Cytoskeletal Regulation of Lung Endothelial Pathobiology in ARDS62025
R01DE016572Ceramide Signaling in the Regulation of Head & Neck Cancer Cell Death and Therapy62025
P30CA008748Cancer Center Support Grant52025
R01AI040098B lymphocyte Migration and Homeostasis52025
ZIADK056014Mouse Models of Novel Sphingolipid Biology and Disease Mechanisms52025
P30CA016672Cancer Center Support Grant42025

1 to 10 of 1,282Source NIH's project files

See all 1,282 nih grants

Papers2,171

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Bile acid signaling in health and disease.Mol Biomed202642825856PubTator, text miningPubMed
Hyaluronidase-enhanced delivery in gene therapy and regenerative medicine for improved vector, cell, and cargo access.Front Drug Deliv202642756066PubTator, text miningPubMed
Sphingosine 1-phosphate signalling contributes to transforming growth factor-β1-induced myofibroblast differentiation in oral cancer.PeerJ202642730290PubTator, text miningPubMed
Decoding the bile acid-mitochondria axis: Implications for disease management and therapeutic opportunities.Pharmacol Res202642668075PubTator, text miningPubMed
JTE-013 ameliorates allergic asthma by targeting the S1PR2-HDAC3-p53 signaling axis to improve mitochondrial homeostasis.Int Immunopharmacol202642574803PubTator, text miningPubMed
The role and mechanism of S1PR2 in endothelial dysfunction and aortic lesions during gestational diabetes mellitus.Placenta202642526136PubTator, text miningPubMed
α-fluoro-β-alanine functions as a β-arrestin1-biased ligand of S1PR2 to upregulate DPD expression in cancer cells.Proc Natl Acad Sci U S A202642475555PubTator, text miningPubMed
Extracellular vesicles from plasma of patients with minimal hepatic encephalopathy induce neuroinflammation and cognitive impairment in rats, which are prevented by treating the patients with rifaximin.
J Neuroinflammation202642343379PubTator, text miningPubMed
The interplay between bile acid metabolism and gut microbiome in biliary tract cancers.Front Microbiomes202642293159PubTator, text miningPubMed
PET Imaging Characterization of Sphingosine-1-Phosphate Receptor 2 in a Mouse Model of Esophageal Adenocarcinoma and Metastatic Lymph Node.Mol Pharm202642250214PubTator, text miningPubMed

1 to 10 of 2,171

See all 2,171 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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