Gene · 93
ACVR2B: activin A receptor type 2B
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. ACVR2B: activin A receptor type 2B. Genes, record 93. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/93
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q13705 | Activin receptor type-2B | 512 | 9 | Ensembl, GeneID, HGNC |
Source UniProt
Patents191
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4820043 A1 | 2026-10-14 | 829 | Q13705 | Espacenet |
| JP 2026120676 A | 2026-07-22 | 39 | Q13705 | Espacenet |
| US 12630608 B2 | 2026-05-19 | 33 | Q13705 | Espacenet |
| JP 2026026172 A | 2026-02-16 | 1 | Q13705 | Espacenet |
| JP 2026010032 A | 2026-01-21 | 18 | Q13705 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 36245 | Q13705 | Espacenet |
| US 12522646 B2 | 2026-01-13 | 46 | Q13705 | Espacenet |
| JP 2025179059 A | 2025-12-09 | 46 | Q13705 | Espacenet |
| US 12492236 B2 | 2025-12-09 | 152 | Q13705 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 6530 | Q13705 | Espacenet |
1 to 10 of 191
See all 191 patentsDrugs2
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
Trials16
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT06901349 | BIMAGRUMAB | PHASE2 | ClinicalTrials.gov | |
| NCT06643728 | BIMAGRUMAB | PHASE2 | ClinicalTrials.gov | |
| NCT05933499 | BIMAGRUMAB | PHASE2 | ClinicalTrials.gov | |
| NCT05911477 | DIBOTERMIN ALFA | ClinicalTrials.gov | ||
| NCT05616013 | BIMAGRUMAB | PHASE2 | 2025-07-18 | ClinicalTrials.gov |
| NCT03005288 | BIMAGRUMAB | PHASE2 | 2020-06-04 | ClinicalTrials.gov |
| NCT02573467 | BIMAGRUMAB | PHASE3 | 2018-03-13 | ClinicalTrials.gov |
| NCT02468674 | BIMAGRUMAB | PHASE2 | 2019-12-09 | ClinicalTrials.gov |
| NCT02333331 | BIMAGRUMAB | PHASE2 | 2019-08-06 | ClinicalTrials.gov |
| NCT02250443 | BIMAGRUMAB | PHASE2/PHASE3 | 2018-04-10 | ClinicalTrials.gov |
1 to 10 of 16
See all 16 trialsNIH grants1,215
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | ACVR2B papers | Newest fiscal year |
|---|---|---|---|
| P30CA054174 | Mays Cancer Center at UT Health SA | 8 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 6 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 5 | 2025 |
| P30CA082709 | Indiana University Melvin and Bren Simon Comprehensive Cancer Center Support Grant | 4 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 3 | 2025 |
| P30CA072720 | Cancer Center Support Grant | 3 | 2025 |
| P30DK058404 | Molecular and Cellular Basis for Digestive Diseases | 3 | 2025 |
| R01HD032067 | Transforming growth factor β family signaling pathways in ovarian and uterine biology | 3 | 2025 |
| P01CA236778 | The role of the macroenvironment in pancreatic cancer-induced cachexia | 2 | 2025 |
| P30AG024832 | UTMB Claude D. Pepper Older Americans Independence Center | 2 | 2025 |
1 to 10 of 1,215Source NIH's project files
See all 1,215 nih grantsPapers1,693
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Mechanotransduction Failure and Molecular Rescue in Gastric Cancer: Kinetotherapy Across the IL-6/STAT3-Myostatin/ACVR2B-Akt/mTOR Axis. | Med Sci (Basel) | 2026 | 42506334 | PubTator, text mining | PubMed |
| Putting the brakes on muscle growth: Myostatin as regulator of disuse atrophy. | Exp Physiol | 2026 | 42503042 | PubTator, text mining | PubMed |
| Imaging-Derived Sarcopenic Obesity and Cardiovascular Outcomes: Insights Into Heart Failure Risk and Muscle Biology. | J Am Coll Cardiol | 2026 | 42383941 | PubTator, text mining | PubMed |
| Myostatin Signaling in Skeletal Muscle: Implications for Athletic Performance. | Compr Physiol | 2026 | 42322019 | PubTator, text mining | PubMed |
| Receptivity of the human male and female fetal caudal genital ligament to gonadal hormones. | Reproduction | 2026 | 41949886 | PubTator, text mining | PubMed |
| BMPR2 Dosage Gates BMP9/10 Signaling Output in Pulmonary Artery Endothelium. | Cells | 2026 | 41892283 | PubTator, text mining | PubMed |
| Combined resistance exercise and essential amino acid intake enhance follistatin/myostatin ratio and muscle fitness in older women: a randomized controlled trial. | J Int Soc Sports Nutr | 2026 | 41863133 | PubTator, text mining | PubMed |
| Kill two birds with one stone: Reprogramming tumor microenvironment with growth differentiation factor 11. | World J Gastroenterol | 2026 | 41810435 | PubTator, text mining | PubMed |
| Spinal cord injury-induced overflow incontinence reshapes the activin-follistatin-inhibin axis in mouse bladder and kidney. | Front Mol Biosci | 2026 | 41788624 | PubTator, text mining | PubMed |
| The therapeutic potential of Myoki, a novel peptide in muscle atrophy: mechanisms and applications. | Front Pharmacol | 2026 | 41769692 | PubTator, text mining | PubMed |
1 to 10 of 1,693
See all 1,693 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/93
GET https://conductscience.org/api/genes/v1/93/patents?page=2