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Gene · 93

ACVR2B: activin A receptor type 2B

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ACVR2B: activin A receptor type 2B. Genes, record 93. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/93

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Gene

Symbol
ACVR2B
HGNC
Name
activin A receptor type 2B
HGNC
NCBI Gene ID
93
NCBI Gene
HGNC ID
HGNC:174
HGNC
Ensembl
ENSG00000114739
NCBI Gene
Aliases
ACTRIIB, ActR-IIB, HTX4
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q13705Activin receptor type-2B5129Ensembl, GeneID, HGNC

Source UniProt

Patents191

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4820043 A12026-10-14829Q13705Espacenet
JP 2026120676 A2026-07-2239Q13705Espacenet
US 12630608 B22026-05-1933Q13705Espacenet
JP 2026026172 A2026-02-161Q13705Espacenet
JP 2026010032 A2026-01-2118Q13705Espacenet
JP 2026004568 A2026-01-1436245Q13705Espacenet
US 12522646 B22026-01-1346Q13705Espacenet
JP 2025179059 A2025-12-0946Q13705Espacenet
US 12492236 B22025-12-09152Q13705Espacenet
EP 4650780 A22025-11-196530Q13705Espacenet

1 to 10 of 191

See all 191 patents

Drugs2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
BIMAGRUMABCHEMBL3137353Activin receptor type-2B antagonistANTAGONISTChEMBL
DIBOTERMIN ALFACHEMBL2109171Activin receptor type-2B agonistAGONISTChEMBL

Trials16

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06901349BIMAGRUMABPHASE2ClinicalTrials.gov
NCT06643728BIMAGRUMABPHASE2ClinicalTrials.gov
NCT05933499BIMAGRUMABPHASE2ClinicalTrials.gov
NCT05911477DIBOTERMIN ALFAClinicalTrials.gov
NCT05616013BIMAGRUMABPHASE22025-07-18ClinicalTrials.gov
NCT03005288BIMAGRUMABPHASE22020-06-04ClinicalTrials.gov
NCT02573467BIMAGRUMABPHASE32018-03-13ClinicalTrials.gov
NCT02468674BIMAGRUMABPHASE22019-12-09ClinicalTrials.gov
NCT02333331BIMAGRUMABPHASE22019-08-06ClinicalTrials.gov
NCT02250443BIMAGRUMABPHASE2/PHASE32018-04-10ClinicalTrials.gov

1 to 10 of 16

See all 16 trials

NIH grants1,215

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleACVR2B papersNewest fiscal year
P30CA054174Mays Cancer Center at UT Health SA82025
P30CA068485Cancer Center Support Grant62025
P30CA008748Cancer Center Support Grant52025
P30CA082709Indiana University Melvin and Bren Simon Comprehensive Cancer Center Support Grant42025
P30CA016672Cancer Center Support Grant32025
P30CA072720Cancer Center Support Grant32025
P30DK058404Molecular and Cellular Basis for Digestive Diseases32025
R01HD032067Transforming growth factor β family signaling pathways in ovarian and uterine biology32025
P01CA236778The role of the macroenvironment in pancreatic cancer-induced cachexia22025
P30AG024832UTMB Claude D. Pepper Older Americans Independence Center22025

1 to 10 of 1,215Source NIH's project files

See all 1,215 nih grants

Papers1,693

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Mechanotransduction Failure and Molecular Rescue in Gastric Cancer: Kinetotherapy Across the IL-6/STAT3-Myostatin/ACVR2B-Akt/mTOR Axis.Med Sci (Basel)202642506334PubTator, text miningPubMed
Putting the brakes on muscle growth: Myostatin as regulator of disuse atrophy.Exp Physiol202642503042PubTator, text miningPubMed
Imaging-Derived Sarcopenic Obesity and Cardiovascular Outcomes: Insights Into Heart Failure Risk and Muscle Biology.J Am Coll Cardiol202642383941PubTator, text miningPubMed
Myostatin Signaling in Skeletal Muscle: Implications for Athletic Performance.Compr Physiol202642322019PubTator, text miningPubMed
Receptivity of the human male and female fetal caudal genital ligament to gonadal hormones.Reproduction202641949886PubTator, text miningPubMed
BMPR2 Dosage Gates BMP9/10 Signaling Output in Pulmonary Artery Endothelium.Cells202641892283PubTator, text miningPubMed
Combined resistance exercise and essential amino acid intake enhance follistatin/myostatin ratio and muscle fitness in older women: a randomized controlled trial.J Int Soc Sports Nutr202641863133PubTator, text miningPubMed
Kill two birds with one stone: Reprogramming tumor microenvironment with growth differentiation factor 11.World J Gastroenterol202641810435PubTator, text miningPubMed
Spinal cord injury-induced overflow incontinence reshapes the activin-follistatin-inhibin axis in mouse bladder and kidney.Front Mol Biosci202641788624PubTator, text miningPubMed
The therapeutic potential of Myoki, a novel peptide in muscle atrophy: mechanisms and applications.Front Pharmacol202641769692PubTator, text miningPubMed

1 to 10 of 1,693

See all 1,693 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/93

GET https://conductscience.org/api/genes/v1/93/patents?page=2