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Gene · 9312

KCNB2: potassium voltage-gated channel subfamily B member 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. KCNB2: potassium voltage-gated channel subfamily B member 2. Genes, record 9312. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9312

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Gene

Symbol
KCNB2
HGNC
Name
potassium voltage-gated channel subfamily B member 2
HGNC
NCBI Gene ID
9312
NCBI Gene
HGNC ID
HGNC:6232
HGNC
Ensembl
ENSG00000182674
NCBI Gene
Aliases
KV2.2, Kv2.2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q92953Potassium voltage-gated channel subfamily B member 29110Ensembl, GeneID, HGNC

Source UniProt

Patents21

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1458756Q92953Espacenet
EP 4641201 A22025-10-2918344Q92953Espacenet
JP 2025529142 A2025-09-042196Q92953Espacenet
US 12371689 B22025-07-292196Q92953Espacenet
JP 2025517969 A2025-06-1218344Q92953Espacenet
US 11673916 B22023-06-1342Q92953Espacenet
US 11446398 B22022-09-2065829Q92953Espacenet
US 11400116 B22022-08-023119Q92953Espacenet
JP 2022524081 A2022-04-27168800Q92953Espacenet
US 11078247 B22021-08-035718Q92953Espacenet

1 to 10 of 21

See all 21 patents

Drugs7

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AMIFAMPRIDINECHEMBL354077Voltage-gated potassium channel blockerBLOCKERChEMBL
AMIFAMPRIDINE PHOSPHATECHEMBL3301611Voltage-gated potassium channel blockerBLOCKERChEMBL
DALFAMPRIDINECHEMBL284348Voltage-gated potassium channel blockerBLOCKERChEMBL
GUANIDINECHEMBL821Voltage-gated potassium channel blockerBLOCKERChEMBL
GUANIDINE HYDROCHLORIDECHEMBL1200728Voltage-gated potassium channel blockerBLOCKERChEMBL
NERISPIRDINECHEMBL2107762Voltage-gated potassium channel blockerBLOCKERChEMBL
TEDISAMILCHEMBL113461Voltage-gated potassium channel blockerBLOCKERChEMBL

Trials86

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07532460DALFAMPRIDINEClinicalTrials.gov
NCT07185347DALFAMPRIDINEPHASE3ClinicalTrials.gov
NCT07171203DALFAMPRIDINEPHASE1ClinicalTrials.gov
NCT06853015DALFAMPRIDINEPHASE1/PHASE2ClinicalTrials.gov
NCT06751784DALFAMPRIDINEPHASE2ClinicalTrials.gov
NCT06596434DALFAMPRIDINEPHASE2ClinicalTrials.gov
NCT06333171DALFAMPRIDINEPHASE2ClinicalTrials.gov
NCT06294821DALFAMPRIDINEPHASE2ClinicalTrials.gov
NCT06136728DALFAMPRIDINEPHASE3ClinicalTrials.gov
NCT05919407AMIFAMPRIDINEPHASE3ClinicalTrials.gov

1 to 10 of 86

See all 86 trials

NIH grants454

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleKCNB2 papersNewest fiscal year
R35DE030045Trigeminal nociceptors: Neural intersection of chronic pain and alveolar bone remodeling32025
U10AA008401Collaborative Study on the Genetics of Alcoholism (COGA).32025
P30CA016672Cancer Center Support Grant22025
P30DK063491Diabetes Research Center (DRC)22025
ZIAAG007270ALZHEIMERS RESEARCH PROJECT: Genetic Markers of Brain Aging22025
K12DA000167Clinician Scientist Training Program (CSTP)12025
P01AG073082Decoding the Multifactorial Etiology of Neural Network Dysfunction in Alzheimer's Disease12025
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant12025
P30CA023074University of Arizona Cancer Center - Cancer Center Support Grant12025
P30CA034196Cancer Center Support (CORE) Grant12025

1 to 10 of 454Source NIH's project files

See all 454 nih grants

Papers339

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
LINE-1 Transcript Heterogeneity in Non-Small Cell Lung Cancers Is Driven by Host Genomic Context and Conserved Functional Hotspots.Cancers (Basel)202641681929PubTator, text miningPubMed
Harnessing retinoic acid metabolism-related genes to identify lung adenocarcinoma subtype and establish a risk model for predicting prognosis and drug therapy response.Comput Biol Chem202641391260PubTator, text miningPubMed
Childhood obesity and DNA methylation in an epigenome-wide association study: findings from the Hokkaido Birth Cohort.Clin Epigenetics202541327469PubTator, text miningPubMed
Kv2/Kv6.4 Heteromeric Potassium Channels Are Expressed in Spinal Motoneurons and Localized at C-Bouton Synapses.Eur J Neurosci202540919874PubTator, text miningPubMed
Taking the "lazy" way identifies KCNB2 as a regulator of SHH-MB maintenance.Dev Cell202540494277PubTator, text miningPubMed
The Shab family potassium channels are highly enriched at the presynaptic terminals of human neurons.J Biol Chem202539880095PubTator, text miningPubMed
A forward genetic screen identifies potassium channel essentiality in SHH medulloblastoma maintenance.Dev Cell202539862856PubTator, text miningPubMed
The KCNB2 gene and its role in neurodevelopmental disorders: Implications for genetics and therapeutic advances.Clin Chim Acta202539577484PubTator, text miningPubMed
Multiomic analysis reveals cellular, transcriptomic and epigenetic changes in intestinal pouches of ulcerative colitis patients.medRxiv202538014192PubTator, text miningPubMed
Association of the dopamine D2 receptor gene SNP rs1800497 with postoperative nausea and vomiting: A prospective cohort study.Eur J Anaesthesiol Intensive Care202439917251PubTator, text miningPubMed

1 to 10 of 339

See all 339 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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