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Paper12412759

Synergistic effects of locally administered cytostatic drugs and a surfactant on the development of delayed-type hypersensitivity to keyhole limpet haemocyanin in mice.

Limpens J and 1 other. Clin Exp Immunol, 1989. Cited by 6 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Synergistic effects of locally administered cytostatic drugs and a surfactant on the development of delayed-type hypersensitivity to keyhole limpet haemocyanin in mice. Papers, record 12412759. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/12412759

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Synergistic effects of locally administered cytostatic drugs and a surfactant on the development of delayed-type hypersensitivity to keyhole limpet haemocyanin in mice.
PubMed
Journal
Clin Exp Immunol
PubMed
Year
1989
PubMed
Publication types
Journal Article, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
6
iCite
Relative citation ratio, by iCite
0.23
iCite
Revised in PubMed
2018-11-13
PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Limpens JJ
2Scheper RJR J

Source PubMed

Topics14

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Antineoplastic AgentsMajor topic
CyclophosphamideMajor topic
Hypersensitivity, DelayedMajor topic
Surface-Active AgentsMajor topic
Adjuvants, Immunologic
Animals
Drug Synergism
Etoposide
Hemocyanins
Immunization
Male
Mice
Mice, Inbred BALB C
Quaternary Ammonium Compounds

Source PubMed

References31

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
14,815,095The role of lipid in the induction of hapten-specific delayed hypersensitivity and contact sensitivity.J Immunol1974https://conductscience.org/library/papers/4815095PubMed
22,917,364Cell-mediated immunity is enhanced by cytostatic drugs continuously released at the site of antigenic stimulation.Cancer Immunol Immunother1989https://conductscience.org/library/papers/2917364PubMed
34,598,018The modifying effect of BCG on the immunological induction of T cells.J Exp Med1974https://conductscience.org/library/papers/4598018PubMed
447,220Delayed hypersensitivity in the mouse.Adv Immunol1975https://conductscience.org/library/papers/47220PubMed
51,095,003Suppression of the immune response by microorganisms.Bacteriol Rev1975https://conductscience.org/library/papers/1095003PubMed
61,084,484Enhancement of delayed hypersensitivity by depletion of suppressor T cells with cyclophosphamide in mice.Nature1976https://conductscience.org/library/papers/1084484PubMed
71,084,997Role of major histocompatibility complex gene products in delayed-type hypersensitivity.Proc Natl Acad Sci U S A1976https://conductscience.org/library/papers/1084997PubMed
8299,883Cyclophosphamide-sensitive T lymphocytes suppress the in vivo generation of antigen-specific cytotoxic T lymphocytes.J Exp Med1977https://conductscience.org/library/papers/299883PubMed
9324,671Synergy, additivism and antagonism in immunosuppression. A critical review.Clin Exp Immunol1977https://conductscience.org/library/papers/324671PubMed
10328,389Dextran sulphate: an adjuvant for cell-mediated immune responses.Immunology1977https://conductscience.org/library/papers/328389PubMed
11338,479Suppression of cell-mediated immune responses by dextran sulphate.Immunology1977https://conductscience.org/library/papers/338479PubMed
12591,002Dimethyl diotadecyl ammonium bromide as adjuvant for delayed hypersensitivity in mice.Immunology1977https://conductscience.org/library/papers/591002PubMed
13306,925Regulation of delayed-type hypersensitivity. III. Effect of cyclophosphamide on the suppressor cells for delayed-type hypersensitivity to sheep erythrocytes in mice.Eur J Immunol1978https://conductscience.org/library/papers/306925PubMed
14521,054Effect of stimulation and blockade of mononuclear phagocyte system on the delayed footpad reaction to SRBC in mice.Immunology1979https://conductscience.org/library/papers/521054PubMed
156,986,203The enhancement of humoral and cellular immune responses by dimethyldioctadecylammonium bromide.Cell Immunol1980https://conductscience.org/library/papers/6986203PubMed
166,248,283
The comparative selectivity of adjuvants for humoral and cell-mediated immunity. II. Effect on delayed-type hypersensitivity in the mouse and guinea pig, and cell-mediated immunity to tumour antigens in the mouse of Freund's incomplete and complete adjuvants, alhydrogel, Corynebacterium parvum, Bordetella pertussis, muramyl dipeptide and saponin.
Clin Exp Immunol1980https://conductscience.org/library/papers/6248283PubMed
176,967,888Relative susceptibilities of T cell subsets involved in delayed-type hypersensitivity to sheep red blood cells to the in vitro action of 4-hydroperoxycyclophosphamide.J Immunol1980https://conductscience.org/library/papers/6967888PubMed
187,011,609Two distinct types of non-specific immunosuppression in murine malaria.Clin Exp Immunol1980https://conductscience.org/library/papers/7011609PubMed
196,788,892Enhancement of delayed hypersensitivity reaction with varieties of anti-cancer drugs. A common biological phenomenon.J Exp Med1981https://conductscience.org/library/papers/6788892PubMed
206,976,414In vitro effects of 4-hydroperoxycyclophosphamide on human immunoregulatory T subset function. I. Selective effects on lymphocyte function in T-B cell collaboration.J Exp Med1982https://conductscience.org/library/papers/6976414PubMed

See all 31 references

Cited by3

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 6 citations.

PMIDTitleJournalYearIn PapersSource
8,774,351Reversal of mucosal tolerance by subcutaneous administration of interleukin-12 at the site of attempted sensitization.Immunology1996https://conductscience.org/library/papers/8774351PubMed
1,879,874Alterations in dendritic cell phenotype and function associated with immunoenhancing effects of a subcutaneously administered cyclophosphamide derivative.Immunology1991https://conductscience.org/library/papers/1879874PubMed
1,828,396Inhibition of T suppressor cell function by local administration of an active cyclophosphamide derivative at the sensitization site.Clin Exp Immunol1991https://conductscience.org/library/papers/1828396PubMed

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

None in this release

  • Grants
  • Trials
  • Comments and corrections
  • Genes
  • Drugs
  • Data

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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