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Paper128562

The Raji cell radioimmune assay for detecting immune complexes in human sera.

Theofilopoulos AN and 2 others. J Clin Invest, 1976. Cited by 883 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. The Raji cell radioimmune assay for detecting immune complexes in human sera. Papers, record 128562. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/128562

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
The Raji cell radioimmune assay for detecting immune complexes in human sera.
PubMed
Journal
J Clin Invest
PubMed
Year
1976
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
883
iCite
Relative citation ratio, by iCite
35.2
iCite
Revised in PubMed
2018-11-13
PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Theofilopoulos ANA N
2Wilson CBC B
3Dixon FJF J

Source PubMed

Topics15

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Antigen-Antibody ComplexMajor topic
Cell LineMajor topic
Immune Complex DiseasesMajor topic
RadioimmunoassayMajor topic
Binding Sites, Antibody
Complement C3
Dengue
Hepatitis B
Humans
Immunoglobulin Fc Fragments
Immunoglobulin G
Lupus Erythematosus, Systemic
Neoplasms
Subacute Sclerosing Panencephalitis
Vascular Diseases

Source PubMed

References66

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
15,778,786Isolation of a fragment (C3a) of the third component of human complement containing anaphylatoxin and chemotactic activity and description of an anaphylatoxin inactivator of human serum.J Exp Med1969https://conductscience.org/library/papers/5778786PubMed
21,081,927Specific concentration of antilymphocyte antibodies in the serum cryoprecipitates of patients with systemic lupus erythematosus.Clin Exp Immunol1975https://conductscience.org/library/papers/1081927PubMed
31,082,388Enhanced uptake by guinea-pig macrophages of radio-iodinated human aggregated immunoglobulin G in the presence of sera from rheumatoid patients with cutaneous vasculitis.Clin Exp Immunol1975https://conductscience.org/library/papers/1082388PubMed
414,321,425BIOLOGICAL ACTIVITIES OF AGGREGATED GAMMA-GLOBULIN. VII. MINIMUM SIZE OF AGGREGATED GAMMA-GLOBULIN OR ITS PIECE 3 REQUIRED FOR THE INDUCTION OF SKIN REACTIVITY AND COMPLEMENT FIXATION.J Immunol1965https://conductscience.org/library/papers/14321425PubMed
514,333,021AUTOANTIBODIES AND DISEASE.Adv Immunol1964https://conductscience.org/library/papers/14333021PubMed
6164,055Virus neutralization and virus-induced immune complex disease. Virus-antibody union resulting in immunoprotection or immunologic injury--two sides of the same coin.Prog Med Virol1975https://conductscience.org/library/papers/164055PubMed
74,098,431Association between polyarteritis and Australia antigen.Lancet1970https://conductscience.org/library/papers/4098431PubMed
84,098,878Precipitin reactions of the C1q component of complement with aggregated gamma-globulin and immune complexes in gel diffusion.Immunology1970https://conductscience.org/library/papers/4098878PubMed
94,113,510Interaction of aggregated -globulin with B lymphocytes.J Exp Med1972https://conductscience.org/library/papers/4113510PubMed
104,119,708Circulating immune complexes in dermatitis herpetiformis.Lancet1973https://conductscience.org/library/papers/4119708PubMed
114,127,837Aggregation of human blood platelets by immune complexes in the sedimentation pattern test.Scand J Haematol Suppl1973https://conductscience.org/library/papers/4127837PubMed
124,132,041Detection and radioassay of soluble circulating immune complexes using guinea pig peritoneal exudate cells.Nature1974https://conductscience.org/library/papers/4132041PubMed
134,138,539Binding of soluble immune complexes to human lymphoblastoid cells. II. Use of Raji cells to detect circulating immune complexes in animal and human sera.J Exp Med1974https://conductscience.org/library/papers/4138539PubMed
144,138,924Analyses of lymphocytes from patients with rheumatoid arthritis and systemic lupus erythematosus. Occurrence of interfering cold-reactive antilymphocyte antibodies.J Clin Invest1974https://conductscience.org/library/papers/4138924PubMed
154,139,225Binding of soluble immune complexes to human lymphoblastoid cells. I. Characterization of receptors for IgG Fc and complement and description of the binding mechanism.J Exp Med1974https://conductscience.org/library/papers/4139225PubMed
164,155,412The role of circulating hepatitis B antigen/antibody immune complexes in the pathogenesis of vascular and hepatic manifestations in polyarteritis nodosa.J Clin Pathol1974https://conductscience.org/library/papers/4155412PubMed
174,160,044A method of trace iodination of proteins for immunologic studies.Int Arch Allergy Appl Immunol1966https://conductscience.org/library/papers/4160044PubMed
184,168,098Immunological studies concerning the nephritis of systemic lupus erythematosus.J Exp Med1967https://conductscience.org/library/papers/4168098PubMed
194,179,834Pathogenesis of chronic disease associated with persistent lymphocytic choriomeningitis viral infection. I. Relationship of antibody production to disease in neonatally infected mice.J Exp Med1969https://conductscience.org/library/papers/4179834PubMed
204,197,968Circulating immune complexes in inflammatory bowel disease.Clin Exp Immunol1973https://conductscience.org/library/papers/4197968PubMed

See all 66 references

Cited by199

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 883 citations.

PMIDTitleJournalYearIn PapersSource
38,828,730Navigating an enigma: the continuing journey of autoimmunity discoveries.J Clin Invest2024https://conductscience.org/library/papers/38828730PubMed
34,202,570Dengue and the Lectin Pathway of the Complement System.Viruses2021https://conductscience.org/library/papers/34202570PubMed
33,362,259A proteomics-based method for identifying antigens within immune complexes.PLoS One2020https://conductscience.org/library/papers/33362259PubMed
31,263,461Kawasaki Disease: The Role of Immune Complexes Revisited.Front Immunol2019https://conductscience.org/library/papers/31263461PubMed
31,260,079High titres of IgM-bound circulating immune complexes and erythrocytic oxidative damage are indicators of dengue severity.Clin Exp Immunol2019https://conductscience.org/library/papers/31260079PubMed
30,120,121Antigen-specific antibody Fc glycosylation enhances humoral immunity via the recruitment of complement.Sci Immunol2018https://conductscience.org/library/papers/30120121PubMed
25,410,854Microparticles provide a novel biomarker to predict severe clinical outcomes of dengue virus infection.J Virol2015https://conductscience.org/library/papers/25410854PubMed
23,154,274TLRs and IFNs: critical pieces of the autoimmunity puzzle.J Clin Invest2012https://conductscience.org/library/papers/23154274PubMed
22,987,294Role of CD61+ cells in thrombocytopenia of dengue patients.Int J Hematol2012https://conductscience.org/library/papers/22987294PubMed
19,388,173Complement and its role in protection and pathogenesis of flavivirus infections.Vaccine2008https://conductscience.org/library/papers/19388173PubMed
18,522,648Vascular endothelium: the battlefield of dengue viruses.FEMS Immunol Med Microbiol2008https://conductscience.org/library/papers/18522648PubMed
15,057,297Dengue: defining protective versus pathologic immunity.J Clin Invest2004https://conductscience.org/library/papers/15057297PubMed
10,698,995An antigen capture enzyme-linked immunosorbent assay reveals high levels of the dengue virus protein NS1 in the sera of infected patients.J Clin Microbiol2000https://conductscience.org/library/papers/10698995PubMed
7,453,086Interaction of circulating immune complexes with granulocyte function in patients with rheumatoid arthritis.Klin Wochenschr1980https://conductscience.org/library/papers/7453086PubMed
7,438,545Quantitation of circulating immune complexes in serum by Raji cells using an enzyme-linked immunosorbent assay.Clin Exp Immunol1980https://conductscience.org/library/papers/7438545PubMed
7,438,537Effect of preformed immune complexes on the clearance and tissue localization of single-stranded DNA in mice.Clin Exp Immunol1980https://conductscience.org/library/papers/7438537PubMed
7,418,261IgA-containing circulating immune complexes in dermatitis herpetiformis, Henoch-Schönlein purpura, systemic lupus erythematosus and other diseases.Clin Exp Immunol1980https://conductscience.org/library/papers/7418261PubMed
7,416,810Tumour markers with unknown functions in gynaecological neoplasia.Arch Gynecol1980https://conductscience.org/library/papers/7416810PubMed
7,399,319Inflammatory bowel disease associated circulating immune complexes.Gut1980https://conductscience.org/library/papers/7399319PubMed
7,386,596Deposition of immune complexes in ovarian follicles of mice with lupus-like syndrome.Am J Pathol1980https://conductscience.org/library/papers/7386596PubMed

See all 199 cited by

Genes2

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
C3718PubTator's text mininghttps://conductscience.org/library/genes/718NCBI Gene
ERVK-13100,861,467PubTator's text mininghttps://conductscience.org/library/genes/100861467NCBI Gene

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

None in this release

  • Grants
  • Trials
  • Comments and corrections
  • Drugs
  • Data

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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