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Paper30120121

Antigen-specific antibody Fc glycosylation enhances humoral immunity via the recruitment of complement.

Lofano G and 17 others. Sci Immunol, 2018. Cited by 81 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Antigen-specific antibody Fc glycosylation enhances humoral immunity via the recruitment of complement. Papers, record 30120121. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/30120121

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Antigen-specific antibody Fc glycosylation enhances humoral immunity via the recruitment of complement.
PubMed
Journal
Sci Immunol
PubMed
Year
2018
PubMed
Publication types
Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
81
iCite
Relative citation ratio, by iCite
2.48
iCite
Revised in PubMed
2026-05-12
PubMed

Authors18

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Lofano GGiuseppehttps://orcid.org/0000-0003-2578-2670
2Gorman MJMatthew J
3Yousif ASAshraf S
4Yu WHWen-Hanhttps://orcid.org/0000-0002-1671-9744
5Fox JMJulie Mhttps://orcid.org/0000-0003-0567-738X
6Dugast ASAnne-Sophie
7Ackerman MEMargaret Ehttps://orcid.org/0000-0002-4253-3476
8Suscovich TJTodd J
9Weiner JJoshuahttps://orcid.org/0000-0003-1054-0628
10Barouch DDanhttps://orcid.org/0000-0001-5127-4659
11Streeck HHendrik
12Little SSusanhttps://orcid.org/0000-0002-7645-9737
13Smith DDavey
14Richman DDouglashttps://orcid.org/0000-0003-0962-9254
15Lauffenburger DDouglashttps://orcid.org/0000-0002-0050-989X
16Walker BDBruce Dhttps://orcid.org/0000-0001-6122-9245
17Diamond MSMichael Shttps://orcid.org/0000-0002-8791-3165
18Alter GGalit

Source PubMed

Topics14

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Antibodies, NeutralizingMajor topic
Complement System ProteinsMajor topic
HIV AntibodiesMajor topic
Immunoglobulin Fc FragmentsMajor topic
Animals
Antigens, Viral
Cell Line
Female
Glycosylation
Immunity, Humoral
Immunoglobulin G
Mice, Inbred BALB C
Mice, Inbred C57BL
Receptors, Fc

Source PubMed

Grants5

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
UM1 AI126620NIAID NIH HHSUnited StatesUM1AI126620PubMed and NIHNIH RePORTER
R37 AI080289NIAID NIH HHSUnited StatesR37AI080289PubMed and NIHNIH RePORTER
R01 AI102660NIAID NIH HHSUnited StatesR01AI102660PubMed and NIHNIH RePORTER
P30 AI036214NIAID NIH HHSUnited StatesP30AI036214PubMed and NIHNIH RePORTER
U19 AI128751NIAID NIH HHSUnited StatesU19AI128751PubMedNIH RePORTER

References73

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
1102,587Binding of soluble immune complexes to Raji lymphocytes. Role of receptors for complement components, C1q and C3-C3b.Immunology1978https://conductscience.org/library/papers/102587PubMed
211,119,261Immune complex-mediated enhancement of antibody responses without induction of delayed-type hypersensitivity.Scand J Immunol2000https://conductscience.org/library/papers/11119261PubMed
311,479,621Autoimmune disease: why and where it occurs.Nat Med2001https://conductscience.org/library/papers/11479621PubMed
412,644,702Rapid evolution of the neutralizing antibody response to HIV type 1 infection.Proc Natl Acad Sci U S A2003https://conductscience.org/library/papers/12644702PubMed
512,646,921Antibody neutralization and escape by HIV-1.Nature2003https://conductscience.org/library/papers/12646921PubMed
6128,562The Raji cell radioimmune assay for detecting immune complexes in human sera.J Clin Invest1976https://conductscience.org/library/papers/128562PubMed
715,040,582Human antibody-Fc receptor interactions illuminated by crystal structures.Nat Rev Immunol2004https://conductscience.org/library/papers/15040582PubMed
815,466,618C1q governs deposition of circulating immune complexes and leukocyte Fcgamma receptors mediate subsequent neutrophil recruitment.J Exp Med2004https://conductscience.org/library/papers/15466618PubMed
915,630,438Immune complexes as therapy for autoimmunity.J Clin Invest2005https://conductscience.org/library/papers/15630438PubMed
1016,286,018Cell surface recycling of internalized antigen permits dendritic cell priming of B cells.Immunity2005https://conductscience.org/library/papers/16286018PubMed
1116,343,526A simplified method for the rapid fluorometric assessment of antibody-dependent cell-mediated cytotoxicity.J Immunol Methods2006https://conductscience.org/library/papers/16343526PubMed
1216,413,920Fcgamma receptors: old friends and new family members.Immunity2006https://conductscience.org/library/papers/16413920PubMed
1317,121,450Complement lysis activity in autologous plasma is associated with lower viral loads during the acute phase of HIV-1 infection.PLoS Med2006https://conductscience.org/library/papers/17121450PubMed
1417,723,214Germinal-center organization and cellular dynamics.Immunity2007https://conductscience.org/library/papers/17723214PubMed
1517,850,488Complement receptors CD21 and CD35 in humoral immunity.Immunol Rev2007https://conductscience.org/library/papers/17850488PubMed
1617,892,849Human immunodeficiency virus controllers: mechanisms of durable virus control in the absence of antiretroviral therapy.Immunity2007https://conductscience.org/library/papers/17892849PubMed
1718,987,148Factors associated with the development of cross-reactive neutralizing antibodies during human immunodeficiency virus type 1 infection.J Virol2009https://conductscience.org/library/papers/18987148PubMed
1819,079,135The who, how and where of antigen presentation to B cells.Nat Rev Immunol2009https://conductscience.org/library/papers/19079135PubMed
1919,239,901The antigen expressway: follicular conduits carry antigen to B cells.Immunity2009https://conductscience.org/library/papers/19239901PubMed
2019,503,106Immune complex relay by subcapsular sinus macrophages and noncognate B cells drives antibody affinity maturation.Nat Immunol2009https://conductscience.org/library/papers/19503106PubMed

See all 73 references

Cited by65

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 81 citations.

PMIDTitleJournalYearIn PapersSource
41,646,968Immunogenicity and protection mediated by dmLT and alum adjuvants for an HIV-1 vaccine.Front Immunol2025https://conductscience.org/library/papers/41646968PubMed
41,370,123ESAT-6 and CFP-10 reactive IgG in patients with tuberculosis inhibits intracellular bacteria.Cell Rep2025https://conductscience.org/library/papers/41370123PubMed
41,283,508N-Glycosylation of Antibodies: Biological Effects During Infections and Therapeutic Applications.Antibodies (Basel)2025https://conductscience.org/library/papers/41283508PubMed
41,256,685Multivariate analysis of glycogenes reveals coordinated regulation of immunoglobulin glycosylation in an immortalized human B cell system.bioRxiv2025https://conductscience.org/library/papers/41256685PubMed
40,730,842Diversity of immunization strongly impacts SARS-CoV-2 antibody function surrogates.NPJ Vaccines2025https://conductscience.org/library/papers/40730842PubMed
39,988,778The Germline Targeting Vaccine Concept: Overview and Updates from HIV Pre-Clinical and Clinical Trials.Curr HIV Res2026https://conductscience.org/library/papers/39988778PubMed
39,715,286A multivalent binding model infers antibody Fc species from systems serology.PLoS Comput Biol2024https://conductscience.org/library/papers/39715286PubMed
39,634,222Human IgG Subclasses Differ in the Structural Elements of Their N-Glycosylation.ACS Cent Sci2024https://conductscience.org/library/papers/39634222PubMed
39,162,394Antibody-mediated control mechanisms of viral infections.Immunol Rev2024https://conductscience.org/library/papers/39162394PubMed
38,768,956A Fluorinated Sialic Acid Vaccine Lead Against Meningitis B and C.J Am Chem Soc2024https://conductscience.org/library/papers/38768956PubMed
38,497,268Tethering of soluble immune effectors to mucin and chitin reflects a convergent and dynamic role in gut immunity.Philos Trans R Soc Lond B Biol Sci2024https://conductscience.org/library/papers/38497268PubMed
38,200,235Direct enhancement of viral neutralising antibody potency by the complement system: a largely forgotten phenomenon.Cell Mol Life Sci2024https://conductscience.org/library/papers/38200235PubMed
38,170,638Therapeutic efficacy of a potent anti-Venezuelan equine encephalitis virus antibody is contingent on Fc effector function.MAbs2024https://conductscience.org/library/papers/38170638PubMed
38,112,418Understanding Fc function for rational vaccine design against pathogens.mBio2024https://conductscience.org/library/papers/38112418PubMed
37,975,667Distinct Functional Humoral Immune Responses Are Induced after Live Attenuated and Inactivated Seasonal Influenza Vaccination.J Immunol2024https://conductscience.org/library/papers/37975667PubMed
37,640,732Engaging an HIV vaccine target through the acquisition of low B cell affinity.Nat Commun2023https://conductscience.org/library/papers/37640732PubMed
37,600,816Polyfunctional antibodies: a path towards precision vaccines for vulnerable populations.Front Immunol2023https://conductscience.org/library/papers/37600816PubMed
37,155,897Complement contributes to antibody-mediated protection against repeated SHIV challenge.Proc Natl Acad Sci U S A2023https://conductscience.org/library/papers/37155897PubMed
36,980,324IgG N-glycan Signatures as Potential Diagnostic and Prognostic Biomarkers.Diagnostics (Basel)2023https://conductscience.org/library/papers/36980324PubMed
36,921,600Pre-existing Fc profiles shape the evolution of neutralizing antibody breadth following influenza vaccination.Cell Rep Med2023https://conductscience.org/library/papers/36921600PubMed

See all 65 cited by

Genes14

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
C1QA712PubTator's text mininghttps://conductscience.org/library/genes/712NCBI Gene
CD14929PubTator's text mininghttps://conductscience.org/library/genes/929NCBI Gene
CD19930PubTator's text mininghttps://conductscience.org/library/genes/930NCBI Gene
CD4920PubTator's text mininghttps://conductscience.org/library/genes/920NCBI Gene
FAS355PubTator's text mininghttps://conductscience.org/library/genes/355NCBI Gene
FCER22,208PubTator's text mininghttps://conductscience.org/library/genes/2208NCBI Gene
FCGR2A2,212PubTator's text mininghttps://conductscience.org/library/genes/2212NCBI Gene
FCGR2B2,213PubTator's text mininghttps://conductscience.org/library/genes/2213NCBI Gene
FCGR3A2,214PubTator's text mininghttps://conductscience.org/library/genes/2214NCBI Gene
FCGR3B2,215PubTator's text mininghttps://conductscience.org/library/genes/2215NCBI Gene
ITIH43,700PubTator's text mininghttps://conductscience.org/library/genes/3700NCBI Gene
SPINK511,005PubTator's text mininghttps://conductscience.org/library/genes/11005NCBI Gene
TMED210,959PubTator's text mininghttps://conductscience.org/library/genes/10959NCBI Gene
TNFRSF8943PubTator's text mininghttps://conductscience.org/library/genes/943NCBI Gene

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

None in this release

  • Trials
  • Comments and corrections
  • Drugs
  • Data

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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