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Paper · 138139

A mechanism of duplex DNA replication revealed by enzymatic studies of phage phi X174: catalytic strand separation in advance of replication.

Scott JF and 3 others. Proc Natl Acad Sci U S A, 1977. Cited by 251 papers, by iCite.

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ConductScience Library. A mechanism of duplex DNA replication revealed by enzymatic studies of phage phi X174: catalytic strand separation in advance of replication. Papers, record 138139. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/138139

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
A mechanism of duplex DNA replication revealed by enzymatic studies of phage phi X174: catalytic strand separation in advance of replication.
PubMed
Journal
Proc Natl Acad Sci U S A
PubMed
Year
1977
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
251
iCite
Relative citation ratio, by iCite
5.16
iCite
Revised in PubMed
2024-01-09
PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Scott JFJ F
2Eisenberg SS
3Bertsch LLL L
4Kornberg AA

Source PubMed

Topics18

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
ColiphagesMajor topic
DNA ReplicationMajor topic
DNA, CircularMajor topic
DNA, ViralMajor topic
Virus ReplicationMajor topic
Adenosine Triphosphatases
Adenosine Triphosphate
Bacterial Proteins
Carrier Proteins
DNA Polymerase III
DNA, Single-Stranded
Endonucleases
Escherichia coli
Magnesium
Models, Biological
Nucleic Acid Conformation
Templates, Genetic
Viral Proteins

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References25

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
14,874,231Bacteriophage phi-X174 and related viruses.Prog Nucleic Acid Res Mol Biol1968https://conductscience.org/library/papers/4874231PubMed
24,598,307Isolation and function of the gene A initiator of bacteriophage phi-chi 174, a highly specific DNA endonuclease.Proc Natl Acad Sci U S A1974https://conductscience.org/library/papers/4598307PubMed
34,931,509The mechanism of replication of phi X174 single-stranded DNA. II. The role of viral proteins.J Mol Biol1971https://conductscience.org/library/papers/4931509PubMed
44,939,630Effect of cyanide and carbon monoxide on the replication of bacterial DNA in vivo.J Mol Biol1968https://conductscience.org/library/papers/4939630PubMed
55,133,115Formation of the parental replicative form DNA of bacteriophage phi-X174 and initial events in its replication.J Mol Biol1971https://conductscience.org/library/papers/5133115PubMed
65,263,010A proposed common allosteric mechanism for active transport, muscle contraction, and ribosomal translocation.Proc Natl Acad Sci U S A1969https://conductscience.org/library/papers/5263010PubMed
7775,113Bacteriophage phiX174 DNA synthesis in a replication-deficient host: determination of the origin of phiX DNA replication.J Mol Biol1976https://conductscience.org/library/papers/775113PubMed
8778,850DNA synthesis in vitro dependent upon phiX174 replicative form I DNA.Proc Natl Acad Sci U S A1976https://conductscience.org/library/papers/778850PubMed
9786,149Soluble factors required for eukaryotic protein synthesis.Annu Rev Biochem1976https://conductscience.org/library/papers/786149PubMed
10788,919A colony bank containing synthetic Col El hybrid plasmids representative of the entire E. coli genome.Cell1976https://conductscience.org/library/papers/788919PubMed

1 to 10 of 25

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Cited by73

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 251 citations.

PMIDTitleJournalYearIn PapersSource
39,632,877Photocatalytic therapy via photoinduced redox imbalance in biological system.Nat Commun2024https://conductscience.org/library/papers/39632877PubMed
38,832,788Mriyaviruses: small relatives of giant viruses.mBio2024https://conductscience.org/library/papers/38832788PubMed
37,897,358Structural and functional investigation of GajB protein in Gabija anti-phage defense.Nucleic Acids Res2023https://conductscience.org/library/papers/37897358PubMed
34,081,984Regulation of E. coli Rep helicase activity by PriC.J Mol Biol2021https://conductscience.org/library/papers/34081984PubMed
32,449,930E. coli Rep helicase and RecA recombinase unwind G4 DNA and are important for resistance to G4-stabilizing ligands.Nucleic Acids Res2020https://conductscience.org/library/papers/32449930PubMed
31,366,885Multiple origins of prokaryotic and eukaryotic single-stranded DNA viruses from bacterial and archaeal plasmids.Nat Commun2019https://conductscience.org/library/papers/31366885PubMed
30,949,615Rep and UvrD Antagonize One Another at Stalled Replication Forks and This Is Exacerbated by SSB.ACS Omega2019https://conductscience.org/library/papers/30949615PubMed
30,690,484Regulation of Rep helicase unwinding by an auto-inhibitory subdomain.Nucleic Acids Res2019https://conductscience.org/library/papers/30690484PubMed
30,060,236The 2B subdomain of Rep helicase links translocation along DNA with protein displacement.Nucleic Acids Res2018https://conductscience.org/library/papers/30060236PubMed
26,443,783DNA Helicases.EcoSal Plus2010https://conductscience.org/library/papers/26443783PubMed

1 to 10 of 73

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Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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