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Paper · 30690484

Regulation of Rep helicase unwinding by an auto-inhibitory subdomain.

Makurath MA and 4 others. Nucleic Acids Res, 2019. Cited by 27 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Regulation of Rep helicase unwinding by an auto-inhibitory subdomain. Papers, record 30690484. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/30690484

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Regulation of Rep helicase unwinding by an auto-inhibitory subdomain.
PubMed
Journal
Nucleic Acids Res
PubMed
Year
2019
PubMed
Publication types
Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, Non-P.H.S.
PubMed
Citations, by iCite
27
iCite
Relative citation ratio, by iCite
0.93
iCite
Revised in PubMed
2020-03-09
PubMed

Authors5

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Makurath MAMonika A
2Whitley KDKevin D
3Nguyen BBinh
4Lohman TMTimothy M
5Chemla YRYann R

Source PubMed

Topics12

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
DNAMajor topic
DNA HelicasesMajor topic
DNA ReplicationMajor topic
Escherichia coli ProteinsMajor topic
Nucleic Acid ConformationMajor topic
Adenosine Triphosphatases
DNA, Single-Stranded
Escherichia coli
Kinetics
Models, Molecular
Mutation
Protein Domains

Source PubMed

Grants2

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
R01 GM045948NIGMS NIH HHSUnited StatesR01GM045948PubMed and NIHNIH RePORTER
R01 GM120353NIGMS NIH HHSUnited StatesR01GM120353PubMed and NIHNIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References49

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
119,657,341RecQ helicases: multifunctional genome caretakers.Nat Rev Cancer2009https://conductscience.org/library/papers/19657341PubMed
225,883,359Protein structure. Direct observation of structure-function relationship in a nucleic acid-processing enzyme.Science2015https://conductscience.org/library/papers/25883359PubMed
31,313,807DNA-induced dimerization of the Escherichia coli rep helicase. Allosteric effects of single-stranded and duplex DNA.J Biol Chem1992https://conductscience.org/library/papers/1313807PubMed
410,199,404Crystal structures of complexes of PcrA DNA helicase with a DNA substrate indicate an inchworm mechanism.Cell1999https://conductscience.org/library/papers/10199404PubMed
511,428,893E. coli Rep oligomers are required to initiate DNA unwinding in vitro.J Mol Biol2001https://conductscience.org/library/papers/11428893PubMed
616,251,956Repetitive shuttling of a motor protein on DNA.Nature2005https://conductscience.org/library/papers/16251956PubMed
722,636,770Cellular characterization of the primosome and rep helicase in processing and restoration of replication following arrest by UV-induced DNA damage in Escherichia coli.J Bacteriol2012https://conductscience.org/library/papers/22636770PubMed
816,009,938Autoinhibition of Escherichia coli Rep monomer helicase activity by its 2B subdomain.Proc Natl Acad Sci U S A2005https://conductscience.org/library/papers/16009938PubMed
99,288,744Major domain swiveling revealed by the crystal structures of complexes of E. coli Rep helicase bound to single-stranded DNA and ADP.Cell1997https://conductscience.org/library/papers/9288744PubMed
108,639,532ATPase activity of Escherichia coli Rep helicase is dramatically dependent on DNA ligation and protein oligomeric states.Biochemistry1996https://conductscience.org/library/papers/8639532PubMed

1 to 10 of 49

See all 49 references

Cited by22

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 27 citations.

PMIDTitleJournalYearIn PapersSource
42,847,243Deleting the 2B domain of mycobacterial UvrD1 unmasks a latent helicase activity in vitro but effaces UvrD1 activity in nucleotide excision repair in vivo.Nucleic Acids Res2026https://conductscience.org/library/papers/42847243PubMed
42,779,690A superfamily 1 helicase translocates on double-stranded DNA.bioRxiv2026https://conductscience.org/library/papers/42779690PubMed
42,444,602A conserved mechanism for dimerization and activation of superfamily 1A UvrD-family helicases.Nucleic Acids Res2026https://conductscience.org/library/papers/42444602PubMed
41,839,715A conundrum resolved: regulation and activation of UvrD-family DNA helicases/translocases.Trends Biochem Sci2026https://conductscience.org/library/papers/41839715PubMed
41,562,257The transitional kinetics between open and closed Rep structures can be tuned by salt via two intermediate states.Nucleic Acids Res2026https://conductscience.org/library/papers/41562257PubMed
40,048,277Structural basis for dimerization and activation of UvrD-family helicases.Proc Natl Acad Sci U S A2025https://conductscience.org/library/papers/40048277PubMed
38,648,969Subunit Communication within Dimeric SF1 DNA Helicases.J Mol Biol2024https://conductscience.org/library/papers/38648969PubMed
37,844,274Directing Uphill Strand Displacement with an Engineered Superhelicase.ACS Synth Biol2023https://conductscience.org/library/papers/37844274PubMed
37,739,407Helicase Activity Modulation with On-Demand Light-Based Conformational Control.J Am Chem Soc2023https://conductscience.org/library/papers/37739407PubMed
36,938,885Single-molecule visualization of stalled replication-fork rescue by the Escherichia coli Rep helicase.Nucleic Acids Res2023https://conductscience.org/library/papers/36938885PubMed

1 to 10 of 22

See all 22 cited by

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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