Paper · 16735752

Electrogenic Na/HCO3 cotransporter (NBCe1) variants expressed in Xenopus oocytes: functional comparison and roles of the amino and carboxy termini.

McAlear SD and 4 others. J Gen Physiol, 2006. Cited by 82 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Electrogenic Na/HCO3 cotransporter (NBCe1) variants expressed in Xenopus oocytes: functional comparison and roles of the amino and carboxy termini. Papers, record 16735752. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/16735752

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Electrogenic Na/HCO3 cotransporter (NBCe1) variants expressed in Xenopus oocytes: functional comparison and roles of the amino and carboxy termini.; PubMed
Journal: J Gen Physiol; PubMed
Year: 2006; PubMed
Publication types: Comparative Study, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/16735752/; PubMed
DOI: https://doi.org/10.1085/jgp.200609520; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC2151535/; PubMed
The journal: https://conductscience.org/library/journal-index/2985110R; PubMed
Citations, by iCite: 82; iCite
Relative citation ratio, by iCite: 2.1; iCite
Revised in PubMed: 2018-11-13; PubMed

Authors5

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	McAlear SD	Suzanne D
2	Liu X	Xiaofen
3	Williams JB	Jennifer B
4	McNicholas-Bevensee CM	Carmel M
5	Bevensee MO	Mark O

Source PubMed

Topics12

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Gene Expression Regulation	Major topic
Genetic Variation	Major topic
Oocytes	Major topic
Sodium-Bicarbonate Symporters	Major topic
Animals
Female
Mutagenesis, Site-Directed
Patch-Clamp Techniques
Protein Structure, Tertiary
Rats
Transfection
Xenopus laevis

Source PubMed

Grants2

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by
R01 NS046653	NINDS NIH HHS	United States	R01NS046653	PubMed and NIH
NS046653	NINDS NIH HHS	United States	R01NS046653	PubMed and NIH

Source NIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References42

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	14,506,304	Regulation and modulation of pH in the brain.	Physiol Rev	2003	https://conductscience.org/library/papers/14506304	PubMed
2	12,911,818	Carboxyl-terminal truncations of human anion exchanger impair its trafficking to the plasma membrane.	Traffic	2003	https://conductscience.org/library/papers/12911818	PubMed
3	15,273,250	Identification of a carboxyl-terminal motif essential for the targeting of Na+-HCO-3 cotransporter NBC1 to the basolateral membrane.	J Biol Chem	2004	https://conductscience.org/library/papers/15273250	PubMed
4	6,833,997	Intracellular pH regulation in the renal proximal tubule of the salamander. Basolateral HCO3- transport.	J Gen Physiol	1983	https://conductscience.org/library/papers/6833997	PubMed
5	3,943,125	Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes.	Cell	1986	https://conductscience.org/library/papers/3943125	PubMed
6	3,558,825	Stoichiometry of Na+-HCO-3 cotransport in basolateral membrane vesicles isolated from rabbit renal cortex.	J Clin Invest	1987	https://conductscience.org/library/papers/3558825	PubMed
7	2,559,193	An inwardly directed electrogenic sodium-bicarbonate co-transport in leech glial cells.	J Physiol	1989	https://conductscience.org/library/papers/2559193	PubMed
8	2,122,520	Restoration of inactivation in mutants of Shaker potassium channels by a peptide derived from ShB.	Science	1990	https://conductscience.org/library/papers/2122520	PubMed
9	7,907,648	Functional role of the NH2-terminal cytoplasmic domain of a mammalian A-type K channel.	J Gen Physiol	1993	https://conductscience.org/library/papers/7907648	PubMed
10	8,058,760	Regulation of ROMK1 K+ channel activity involves phosphorylation processes.	Proc Natl Acad Sci U S A	1994	https://conductscience.org/library/papers/8058760	PubMed

1 to 10 of 42

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Cited by65

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 82 citations.

PMID	Title	Journal	Year	In Papers	Source
40,877,425	Inactivation mechanisms of Na+/ HCO 3 - cotransporter NBCe1 by phosphorylation.	Commun Biol	2025	https://conductscience.org/library/papers/40877425	PubMed
39,433,547	The Bor1 elevator transport cycle is subject to autoinhibition and activation.	Nat Commun	2024	https://conductscience.org/library/papers/39433547	PubMed
38,631,162	pH regulating mechanisms of astrocytes: A critical component in physiology and disease of the brain.	Cell Calcium	2024	https://conductscience.org/library/papers/38631162	PubMed
37,405,134	NBCe1-B/C-knockout mice exhibit an impaired respiratory response and an enhanced renal response to metabolic acidosis.	Front Physiol	2023	https://conductscience.org/library/papers/37405134	PubMed
37,082,243	Dietary sodium enhances the expression of SLC4 family transporters, IRBIT, L-IRBIT, and PP1 in rat kidney: Insights into the molecular mechanism for renal sodium handling.	Front Physiol	2023	https://conductscience.org/library/papers/37082243	PubMed
35,993,514	Corneal dystrophy mutations R125H and R804H disable SLC4A11 by altering the extracellular pH dependence of the intracellular pK that governs H+(OH-) transport.	Am J Physiol Cell Physiol	2022	https://conductscience.org/library/papers/35993514	PubMed
35,001,662	Acid-base effects of combined renal deletion of NBCe1-A and NBCe1-B.	Am J Physiol Renal Physiol	2022	https://conductscience.org/library/papers/35001662	PubMed
34,884,619	Revisiting the Role of Ser982 Phosphorylation in Stoichiometry Shift of the Electrogenic Na+/qHCO3- Cotransporter NBCe1.	Int J Mol Sci	2021	https://conductscience.org/library/papers/34884619	PubMed
34,679,341	Understanding the Functional Expression of Na+-Coupled SLC4 Transporters in the Renal and Nervous Systems: A Review.	Brain Sci	2021	https://conductscience.org/library/papers/34679341	PubMed
34,447,313	An Overview of Cell-Based Assay Platforms for the Solute Carrier Family of Transporters.	Front Pharmacol	2021	https://conductscience.org/library/papers/34447313	PubMed

1 to 10 of 65

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Genes2

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes	Source
SLC4A1	6,521	PubTator's text mining	https://conductscience.org/library/genes/6521	NCBI Gene
SLC4A4	8,671	PubTator's text mining	https://conductscience.org/library/genes/8671	NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

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ClinicalTrials.govNo license stated
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iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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