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Paper · 169296

Insulin receptor deficiency in genetic and acquired obesity.

Soli AH and 3 others. J Clin Invest, 1975. Cited by 290 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Insulin receptor deficiency in genetic and acquired obesity. Papers, record 169296. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/169296

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Insulin receptor deficiency in genetic and acquired obesity.
PubMed
Journal
J Clin Invest
PubMed
Year
1975
PubMed
Publication types
Comparative Study, Journal Article
PubMed
Citations, by iCite
290
iCite
Relative citation ratio, by iCite
8.22
iCite
Revised in PubMed
2018-11-13
PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Soli AHA H
2Kahn CRC R
3Neville DM JrD M
4Roth JJ

Source PubMed

Topics21

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
InsulinMajor topic
ObesityMajor topic
Receptors, Cell SurfaceMajor topic
Adipose Tissue
Age Factors
Animals
Body Weight
Cell Membrane
Diet, Reducing
Disease Models, Animal
Heterozygote
Homozygote
Hyperinsulinism
Insulin Resistance
Liver
Mice
Mice, Inbred C57BL
Mice, Inbred Strains
Mice, Obese
Mutation
T-Lymphocytes

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References27

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
25,263,677Ventromedial hypothalamus and hyperphagia in hyperglycemic obese mice.Am J Physiol1970https://conductscience.org/library/papers/5263677PubMed
34,369,380Thymic lymphocytes in obese (ob-ob) mice. A mirror of the insulin receptor defect in liver and fat.J Biol Chem1974https://conductscience.org/library/papers/4369380PubMed
44,359,334Insulin-dependent regulation of insulin receptor concentrations: a direct demonstration in cell culture.Proc Natl Acad Sci U S A1974https://conductscience.org/library/papers/4359334PubMed
54,348,209Insulin-receptor interaction in the obese-hyperglycemic mouse. A model of insulin resistance.J Biol Chem1973https://conductscience.org/library/papers/4348209PubMed
64,501,590Insulin receptors in human circulating cells and fibroblasts.Proc Natl Acad Sci U S A1972https://conductscience.org/library/papers/4501590PubMed
713,846,364Immunoassay of endogenous plasma insulin in man.J Clin Invest1960https://conductscience.org/library/papers/13846364PubMed
84,362,069Quantitative aspects of the insulin-receptor interaction in liver plasma membranes.J Biol Chem1974https://conductscience.org/library/papers/4362069PubMed
94,354,162Peptide hormone binding to receptors: a review of direct studies in vitro.Metabolism1973https://conductscience.org/library/papers/4354162PubMed
105,033,396Insulin interactions with liver plasma membranes. Independence of binding of the hormone and its degradation.J Biol Chem1972https://conductscience.org/library/papers/5033396PubMed
114,939,113Amelioration of insulin resistance in obese mice.Am J Physiol1971https://conductscience.org/library/papers/4939113PubMed

1 to 10 of 27

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Cited by53

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 290 citations.

PMIDTitleJournalYearIn PapersSource
31,001,084NCS-1 Deficiency Is Associated With Obesity and Diabetes Type 2 in Mice.Front Mol Neurosci2019https://conductscience.org/library/papers/31001084PubMed
30,067,154Mechanisms of Insulin Action and Insulin Resistance.Physiol Rev2018https://conductscience.org/library/papers/30067154PubMed
27,207,510Lipodystrophy Due to Adipose Tissue-Specific Insulin Receptor Knockout Results in Progressive NAFLD.Diabetes2016https://conductscience.org/library/papers/27207510PubMed
26,974,159PI3-kinase mutation linked to insulin and growth factor resistance in vivo.J Clin Invest2016https://conductscience.org/library/papers/26974159PubMed
23,620,336Effects of CB1 receptor blockade on monosodium glutamate induced hypometabolic and hypothalamic obesity in rats.Naunyn Schmiedebergs Arch Pharmacol2013https://conductscience.org/library/papers/23620336PubMed
9,399,964Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse.J Clin Invest1997https://conductscience.org/library/papers/9399964PubMed
7,236,988Down-regulation of the sodium pump following chronic exposure of HeLa cells and chick embryo heart cells to ouabain.Br J Pharmacol1981https://conductscience.org/library/papers/7236988PubMed
7,179,734Hepatic ultrastructure in leprechaunism. Hepatic ultrastructural evidence suggesting a syndrome with defective hepatic glucose release.Virchows Arch A Pathol Anat Histol1982https://conductscience.org/library/papers/7179734PubMed
7,031,662Insulin-induced receptor loss in cultured human lymphocytes is due to accelerated receptor degradation.Proc Natl Acad Sci U S A1981https://conductscience.org/library/papers/7031662PubMed
7,009,283Glucose storage and oxidation in different degrees of human obesity measured by continuous indirect calorimetry.Diabetologia1981https://conductscience.org/library/papers/7009283PubMed

1 to 10 of 53

See all 53 cited by

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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