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Paper · 4359334

Insulin-dependent regulation of insulin receptor concentrations: a direct demonstration in cell culture.

Gavin JR and 4 others. Proc Natl Acad Sci U S A, 1974. Cited by 1,267 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Insulin-dependent regulation of insulin receptor concentrations: a direct demonstration in cell culture. Papers, record 4359334. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/4359334

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Insulin-dependent regulation of insulin receptor concentrations: a direct demonstration in cell culture.
PubMed
Journal
Proc Natl Acad Sci U S A
PubMed
Year
1974
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
1,267
iCite
Relative citation ratio, by iCite
33.7
iCite
Revised in PubMed
2019-05-01
PubMed

Authors5

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Gavin JR 3rdJ R
2Roth JJ
3Neville DM JrD M
4de Meyts PP
5Buell DND N

Source PubMed

Topics9

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
InsulinMajor topic
LymphocytesMajor topic
Receptors, Cell SurfaceMajor topic
Binding Sites
Cells, Cultured
Humans
Iodine Radioisotopes
Kinetics
Temperature

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References34

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
14,719,190Relationship between fasting plasma insulin level and resistance to insulin-mediated glucose uptake in normal and diabetic subjects.Diabetes1973https://conductscience.org/library/papers/4719190PubMed
24,244,874Leydig cell function in men with gonadotrophin-producing testicular tumors.J Clin Endocrinol Metab1970https://conductscience.org/library/papers/4244874PubMed
34,354,452Decreased binding of insulin to its receptors in rats with hormone induced insulin resistance.Biochem Biophys Res Commun1973https://conductscience.org/library/papers/4354452PubMed
44,626,851Ligand-induced movement of lymphocyte membrane macromolecules. I. Analysis by immunofluorescence and ultrastructural radioautography.J Exp Med1972https://conductscience.org/library/papers/4626851PubMed
55,441,542The effect of fasting, diet, and actinomycin D on insulin secretion in the rat.J Clin Invest1970https://conductscience.org/library/papers/5441542PubMed
64,169,031Synthesis of immunoglobulins by human cell lines in tissue culture.J Immunol1967https://conductscience.org/library/papers/4169031PubMed
74,319,388Radioreceptor assay of adrenocorticotropic hormone: new approach to assay of polypeptide hormones in plasma.Science1970https://conductscience.org/library/papers/4319388PubMed
84,348,209Insulin-receptor interaction in the obese-hyperglycemic mouse. A model of insulin resistance.J Biol Chem1973https://conductscience.org/library/papers/4348209PubMed
94,501,590Insulin receptors in human circulating cells and fibroblasts.Proc Natl Acad Sci U S A1972https://conductscience.org/library/papers/4501590PubMed
104,913,946Human insulin secretion: as integrated approach.Annu Rev Med1970https://conductscience.org/library/papers/4913946PubMed

1 to 10 of 34

See all 34 references

Cited by233

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 1,267 citations.

PMIDTitleJournalYearIn PapersSource
41,572,434The Complex Relation of Branched-Chain Amino Acids and Inflammation in the Obesity and Diabetes Context.Obes Rev2026https://conductscience.org/library/papers/41572434PubMed
41,440,753Drug-Induced Glucose Metabolism Disorders: Role of Aryl Hydrocarbon Receptor.J Xenobiot2025https://conductscience.org/library/papers/41440753PubMed
40,247,011Insulin resistance in type 2 diabetes mellitus.Nat Rev Endocrinol2025https://conductscience.org/library/papers/40247011PubMed
40,105,689IGF1 Signaling Regulates Neuropeptide Expression in Hypothalamic Neurons Under Physiological and Pathological Conditions.Endocrinology2025https://conductscience.org/library/papers/40105689PubMed
39,572,596Multi-layered proteomics identifies insulin-induced upregulation of the EphA2 receptor via the ERK pathway which is dependent on low IGF1R level.Sci Rep2024https://conductscience.org/library/papers/39572596PubMed
38,980,195The association of dietary indices for hyperinsulinemia and insulin resistance with the risk of metabolic syndrome: a population-based cross-sectional study.J Clin Hypertens (Greenwich)2024https://conductscience.org/library/papers/38980195PubMed
38,926,439In vitro effect of visfatin on endocrine functions of the porcine corpus luteum.Sci Rep2024https://conductscience.org/library/papers/38926439PubMed
38,791,525Overnutrition, Hyperinsulinemia and Ectopic Fat: It Is Time for A Paradigm Shift in the Management of Type 2 Diabetes.Int J Mol Sci2024https://conductscience.org/library/papers/38791525PubMed
38,132,154The Effect of Visfatin on the Functioning of the Porcine Pituitary Gland: An In Vitro Study.Cells2023https://conductscience.org/library/papers/38132154PubMed
37,880,346Visfatin in the porcine pituitary gland: expression and regulation of secretion during the oestrous cycle and early pregnancy.Sci Rep2023https://conductscience.org/library/papers/37880346PubMed

1 to 10 of 233

See all 233 cited by

Genes2

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
INS3,630PubTator's text mininghttps://conductscience.org/library/genes/3630NCBI Gene
INSR3,643PubTator's text mininghttps://conductscience.org/library/genes/3643NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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