Paper · 170678

Antibodies that impair insulin receptor binding in an unusual diabetic syndrome with severe insulin resistance.

Flier JS and 3 others. Science, 1975. Cited by 448 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Antibodies that impair insulin receptor binding in an unusual diabetic syndrome with severe insulin resistance. Papers, record 170678. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/170678

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Antibodies that impair insulin receptor binding in an unusual diabetic syndrome with severe insulin resistance.; PubMed
Journal: Science; PubMed
Year: 1975; PubMed
Publication types: Journal Article; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/170678/; PubMed
DOI: https://doi.org/10.1126/science.170678; PubMed
The journal: https://conductscience.org/library/journal-index/0404511; PubMed
Citations, by iCite: 448; iCite
Relative citation ratio, by iCite: 11.1; iCite
Revised in PubMed: 2019-06-18; PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Flier JS	J S
2	Kahn CR	C R
3	Roth J	J
4	Bar RS	R S

Source PubMed

Topics16

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Autoantibodies	Major topic
Diabetes Mellitus	Major topic
Insulin	Major topic
Insulin Resistance	Major topic
Receptors, Cell Surface	Major topic
Animals
Antigen-Antibody Reactions
Binding Sites
Erythrocytes
Female
Humans
Liver
Lymphocytes
Monocytes
Rats
Syndrome

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References0

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

None in this release.

Cited by110

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 448 citations.

PMID	Title	Journal	Year	In Papers	Source
41,706,540	Rheumatologic Manifestations of Patients With Type B Insulin Resistance.	Arthritis Care Res (Hoboken)	2026	https://conductscience.org/library/papers/41706540	PubMed
41,204,250	DNA methylation reshapes the expression of adipokines and adipose factors in white adipose tissues.	Epigenetics Chromatin	2025	https://conductscience.org/library/papers/41204250	PubMed
40,968,430	Severe Insulin Resistance: Diagnosis and Management.	Curr Diabetes Rev	2026	https://conductscience.org/library/papers/40968430	PubMed
40,565,151	Severe Insulin Resistance Syndromes: Clinical Spectrum and Management.	Int J Mol Sci	2025	https://conductscience.org/library/papers/40565151	PubMed
39,966,374	Energy metabolism in health and diseases.	Signal Transduct Target Ther	2025	https://conductscience.org/library/papers/39966374	PubMed
39,948,335	Pancreatic endocrine and exocrine signaling and crosstalk in physiological and pathological status.	Signal Transduct Target Ther	2025	https://conductscience.org/library/papers/39948335	PubMed
36,869,714	A Novel In Vitro Assay Correlates Insulin Receptor Autoantibodies With Fasting Insulin in Type B Insulin Resistance.	J Clin Endocrinol Metab	2023	https://conductscience.org/library/papers/36869714	PubMed
36,830,626	Understanding Insulin in the Age of Precision Medicine and Big Data: Under-Explored Nature of Genomics.	Biomolecules	2023	https://conductscience.org/library/papers/36830626	PubMed
36,721,839	Syndromes of autoantibodies to the insulin receptor.	Int J Biochem Mol Biol	2022	https://conductscience.org/library/papers/36721839	PubMed
36,275,943	Late Systemic Lupus Erythematosus-Associated Insulin Resistance Syndrome: A Rare Cause of De Novo Diabetes Mellitus.	Case Rep Med	2022	https://conductscience.org/library/papers/36275943	PubMed

1 to 10 of 110

See all 110 cited by

Genes2

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes	Source
INS	3,630	PubTator's text mining	https://conductscience.org/library/genes/3630	NCBI Gene
INSR	3,643	PubTator's text mining	https://conductscience.org/library/genes/3643	NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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