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Paper · 17517123

Comparative sequence analysis of leucine-rich repeats (LRRs) within vertebrate toll-like receptors.

Matsushima N and 6 others. BMC Genomics, 2007. Cited by 281 papers, by iCite.

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ConductScience Library. Comparative sequence analysis of leucine-rich repeats (LRRs) within vertebrate toll-like receptors. Papers, record 17517123. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/17517123

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Comparative sequence analysis of leucine-rich repeats (LRRs) within vertebrate toll-like receptors.
PubMed
Journal
BMC Genomics
PubMed
Year
2007
PubMed
Publication types
Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
281
iCite
Relative citation ratio, by iCite
6.24
iCite
Revised in PubMed
2018-11-13
PubMed

Authors7

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Matsushima NNorio
2Tanaka TTakanori
3Enkhbayar PPurevjav
4Mikami TTomoko
5Taga MMasae
6Yamada KKeiko
7Kuroki YYoshio

Source PubMed

Topics15

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Amino Acid MotifsMajor topic
Genetic VariationMajor topic
Immunity, InnateMajor topic
Multigene FamilyMajor topic
Toll-Like ReceptorsMajor topic
VertebratesMajor topic
Amino Acid Sequence
Animals
Computational Biology
Conserved Sequence
Humans
Molecular Sequence Data
Protein Structure, Secondary
Protein Structure, Tertiary
Sequence Alignment

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References76

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
115,496,984Binding site for Robo receptors revealed by dissection of the leucine-rich repeat region of Slit.EMBO J2004https://conductscience.org/library/papers/15496984PubMed
215,662,415Structure of human follicle-stimulating hormone in complex with its receptor.Nature2005https://conductscience.org/library/papers/15662415PubMed
315,665,869The snake venom protein botrocetin acts as a biological brace to promote dysfunctional platelet aggregation.Nat Struct Mol Biol2005https://conductscience.org/library/papers/15665869PubMed
415,644,310Crystal structure of CD14 and its implications for lipopolysaccharide signaling.J Biol Chem2005https://conductscience.org/library/papers/15644310PubMed
515,585,524Porter: a new, accurate server for protein secondary structure prediction.Bioinformatics2005https://conductscience.org/library/papers/15585524PubMed
615,980,571SCRATCH: a protein structure and structural feature prediction server.Nucleic Acids Res2005https://conductscience.org/library/papers/15980571PubMed
715,976,025The evolution of vertebrate Toll-like receptors.Proc Natl Acad Sci U S A2005https://conductscience.org/library/papers/15976025PubMed
815,961,631Crystal structure of human toll-like receptor 3 (TLR3) ectodomain.Science2005https://conductscience.org/library/papers/15961631PubMed
916,043,704The molecular structure of the Toll-like receptor 3 ligand-binding domain.Proc Natl Acad Sci U S A2005https://conductscience.org/library/papers/16043704PubMed
1016,209,941Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase.Mol Cell2005https://conductscience.org/library/papers/16209941PubMed

1 to 10 of 76

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Cited by131

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 281 citations.

PMIDTitleJournalYearIn PapersSource
42,582,202Toll-like receptors in fish: evolution, structure, immune signaling, and translational prospects for adjuvant-based vaccine design in aquaculture.Front Immunol2026https://conductscience.org/library/papers/42582202PubMed
42,213,280TLR ligands as immunomodulators: mechanistic insights and therapeutic potential in infectious and inflammatory diseases.Mol Biol Rep2026https://conductscience.org/library/papers/42213280PubMed
41,681,491Molecular Cloning and Expression Responses to Streptococcus agalactiae and Aeromonas veronii of TLR19, TLR20, and TLR21 in Schizothorax prenanti.Animals (Basel)2026https://conductscience.org/library/papers/41681491PubMed
41,577,712The insect Toll pathway activates antibacterial immunity against the citrus Huanglongbing pathogen.Nat Commun2026https://conductscience.org/library/papers/41577712PubMed
41,373,826Interferon-Based Therapeutics in Cancer Therapy: Past, Present, and Future.Int J Mol Sci2025https://conductscience.org/library/papers/41373826PubMed
40,805,699Transcriptome Analysis and Functional Characterization of the HvLRR_8-1 Gene Involved in Barley Resistance to Pyrenophora graminea.Plants (Basel)2025https://conductscience.org/library/papers/40805699PubMed
40,640,149Pattern recognition receptors: function, regulation and therapeutic potential.Signal Transduct Target Ther2025https://conductscience.org/library/papers/40640149PubMed
39,771,299Salicylic Acid-Induced Expression Profiles of LRR and LRR-RLK Candidate Genes Modulate Mungbean Yellow Mosaic India Virus Resistance in Blackgram and Its Two Wild Non-Progenitors.Plants (Basel)2024https://conductscience.org/library/papers/39771299PubMed
39,729,468Role of Toll-like receptor 2 during infection of Leptospira spp: A systematic review.PLoS One2024https://conductscience.org/library/papers/39729468PubMed
38,995,177TLR10 (CD290) Is a Regulator of Immune Responses in Human Plasmacytoid Dendritic Cells.J Immunol2024https://conductscience.org/library/papers/38995177PubMed

1 to 10 of 131

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Genes41

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
ASPN54,829PubTator's text mininghttps://conductscience.org/library/genes/54829NCBI Gene
BGN633PubTator's text mininghttps://conductscience.org/library/genes/633NCBI Gene
CD14929PubTator's text mininghttps://conductscience.org/library/genes/929NCBI Gene
CHAD1,101PubTator's text mininghttps://conductscience.org/library/genes/1101NCBI Gene
DCN1,634PubTator's text mininghttps://conductscience.org/library/genes/1634NCBI Gene
DLC110,395PubTator's text mininghttps://conductscience.org/library/genes/10395NCBI Gene
ECM21,842PubTator's text mininghttps://conductscience.org/library/genes/1842NCBI Gene
EPYC1,833PubTator's text mininghttps://conductscience.org/library/genes/1833NCBI Gene
FMOD2,331PubTator's text mininghttps://conductscience.org/library/genes/2331NCBI Gene
FSHR2,492PubTator's text mininghttps://conductscience.org/library/genes/2492NCBI Gene

1 to 10 of 41

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Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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