Paper · 17538624

Gene-specific control of inflammation by TLR-induced chromatin modifications.

Foster SL and 2 others. Nature, 2007. Cited by 1,097 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Gene-specific control of inflammation by TLR-induced chromatin modifications. Papers, record 17538624. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/17538624

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Gene-specific control of inflammation by TLR-induced chromatin modifications.; PubMed
Journal: Nature; PubMed
Year: 2007; PubMed
Publication types: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/17538624/; PubMed
DOI: https://doi.org/10.1038/nature05836; PubMed
The journal: https://conductscience.org/library/journal-index/0410462; PubMed
Citations, by iCite: 1,097; iCite
Relative citation ratio, by iCite: 20.7; iCite
Revised in PubMed: 2022-04-09; PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Foster SL	Simmie L
2	Hargreaves DC	Diana C
3	Medzhitov R	Ruslan

Source PubMed

Topics14

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Chromatin	Major topic
Gene Expression Regulation	Major topic
Inflammation	Major topic
Toll-Like Receptor 4	Major topic
Animals
Cells, Cultured
Chromatin Assembly and Disassembly
Histones
Lipopolysaccharides
Macrophages
Mice
Models, Genetic
Promoter Regions, Genetic
Transcription, Genetic

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections1

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

Kind	PMID	Title	In Papers
Comment in	17,581,569	Immunology: Short-term memory.	https://conductscience.org/library/papers/17581569

Source PubMed

References0

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

None in this release.

Cited by759

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 1,097 citations.

PMID	Title	Journal	Year	In Papers	Source
42,928,367	The memory of the tumor microenvironment: epigenetic scarring and the hysteretic logic of therapeutic relapse.	Oncogene	2026	https://conductscience.org/library/papers/42928367	PubMed
42,920,536	Immunometabolic synaptopathy: linking metabolic syndrome to epileptogenesis through trained immunity and parvalbumin interneuron vulnerability.	Front Cell Neurosci	2026	https://conductscience.org/library/papers/42920536	PubMed
42,904,035	PGRP-SC-mediated innate immune memory against pathogenic bacteria in Drosophila.	Hlife	2026	https://conductscience.org/library/papers/42904035	PubMed
42,873,311	The epigenetic-metabolic axis of trained immunity: dual roles in disease pathogenesis and intervention.	J Mol Med (Berl)	2026	https://conductscience.org/library/papers/42873311	PubMed
42,848,422	Transcriptional regulation and function of GPR18 in macrophage subtype specification.	Proc Natl Acad Sci U S A	2026	https://conductscience.org/library/papers/42848422	PubMed
42,812,909	Trained immunity and related memory responses in lung health and disease.	Front Immunol	2026	https://conductscience.org/library/papers/42812909	PubMed
42,787,037	Point-of-care LPS-induced TNF-α release testing for early sepsis risk stratification in the emergency department.	Front Immunol	2026	https://conductscience.org/library/papers/42787037	PubMed
42,694,164	Genome-wide H3K4me3 profiling of circulating immune cells reveals dynamic epigenetic reprogramming during acute critical COVID-19.	Front Immunol	2026	https://conductscience.org/library/papers/42694164	PubMed
42,646,601	Early Identification of a Cytokine-Low Immune Phenotype in Suspected Sepsis Using a Point-of-Care Whole-Blood TNF-α Release Assay.	Med Sci (Basel)	2026	https://conductscience.org/library/papers/42646601	PubMed
42,572,925	Mycoplasma Contamination Alters the Expression Profile of Pro-Inflammatory Cytokines by Human Innate Immune Cells.	Cell Biochem Funct	2026	https://conductscience.org/library/papers/42572925	PubMed

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Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes
TLR4	7,099	PubTator's text mining	https://conductscience.org/library/genes/7099

Source NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data1

The data bank entries PubMed's record names. Trial numbers are under Trials.

Data bank	Accession
GEO	GSE7348

Source GEO

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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