Paper · 19084002

Examining the binding properties of MK-0974: a CGRP receptor antagonist for the acute treatment of migraine.

Moore EL and 6 others. Eur J Pharmacol, 2009. Cited by 23 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Examining the binding properties of MK-0974: a CGRP receptor antagonist for the acute treatment of migraine. Papers, record 19084002. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/19084002

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Examining the binding properties of MK-0974: a CGRP receptor antagonist for the acute treatment of migraine.; PubMed
Journal: Eur J Pharmacol; PubMed
Year: 2009; PubMed
Publication types: Journal Article; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/19084002/; PubMed
DOI: https://doi.org/10.1016/j.ejphar.2008.11.050; PubMed
The journal: https://conductscience.org/library/journal-index/1254354; PubMed
Citations, by iCite: 23; iCite
Relative citation ratio, by iCite: 0.64; iCite
Revised in PubMed: 2018-12-01; PubMed

Authors7

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Moore EL	Eric L
2	Burgey CS	Christopher S
3	Paone DV	Daniel V
4	Shaw AW	Anthony W
5	Tang YS	Yui S
6	Kane SA	Stefanie A
7	Salvatore CA	Christopher A

Source PubMed

Topics12

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Azepines	Major topic
Calcitonin Gene-Related Peptide Receptor Antagonists	Major topic
Imidazoles	Major topic
Migraine Disorders	Major topic
Receptors, Calcitonin Gene-Related Peptide	Major topic
Animals
Binding, Competitive
Humans
Kinetics
Macaca mulatta
Protein Binding
Tritium

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References0

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

None in this release.

Cited by8

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 23 citations.

PMID	Title	Journal	Year	In Papers	Source
40,172,014	Characterization of the Two-Domain Peptide Binding Mechanism of the Human CGRP Receptor for CGRP and the Ultrahigh Affinity ssCGRP Variant.	Biochemistry	2025	https://conductscience.org/library/papers/40172014	PubMed
38,670,438	Variable CGRP family peptide signaling durations and the structural determinants thereof.	Biochem Pharmacol	2024	https://conductscience.org/library/papers/38670438	PubMed
36,454,715	CGRP physiology, pharmacology, and therapeutic targets: migraine and beyond.	Physiol Rev	2023	https://conductscience.org/library/papers/36454715	PubMed
35,910,262	Cerebro-Cerebellar Networks in Migraine Symptoms and Headache.	Front Pain Res (Lausanne)	2022	https://conductscience.org/library/papers/35910262	PubMed
34,513,925	Exploring Ligand Binding to Calcitonin Gene-Related Peptide Receptors.	Front Mol Biosci	2021	https://conductscience.org/library/papers/34513925	PubMed
25,230,231	Quinoline derivatives: candidate drugs for a class B G-protein coupled receptor, the calcitonin gene-related peptide receptor, a cause of migraines.	CNS Neurol Disord Drug Targets	2014	https://conductscience.org/library/papers/25230231	PubMed
20,512,399	Allosteric antagonist binding sites in class B GPCRs: corticotropin receptor 1.	J Comput Aided Mol Des	2010	https://conductscience.org/library/papers/20512399	PubMed
20,433,208	Calcitonin gene-related peptide (CGRP) receptor antagonists in the treatment of migraine.	CNS Drugs	2010	https://conductscience.org/library/papers/20433208	PubMed

Genes2

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes	Source
ADM	133	PubTator's text mining	https://conductscience.org/library/genes/133	NCBI Gene
CALCA	796	PubTator's text mining	https://conductscience.org/library/genes/796	NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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