Paper · 40172014
Characterization of the Two-Domain Peptide Binding Mechanism of the Human CGRP Receptor for CGRP and the Ultrahigh Affinity ssCGRP Variant.
Babin KM and 4 others. Biochemistry, 2025. Cited by 5 papers, by iCite.
11 sourcespapers-2026-11-12-0.1.0
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ConductScience Library. Characterization of the Two-Domain Peptide Binding Mechanism of the Human CGRP Receptor for CGRP and the Ultrahigh Affinity ssCGRP Variant. Papers, record 40172014. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/40172014
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Paper
PubMed's record of the paper, with iCite's citation figures. No abstract is shown.
- Title
- Characterization of the Two-Domain Peptide Binding Mechanism of the Human CGRP Receptor for CGRP and the Ultrahigh Affinity ssCGRP Variant.
- PubMed
Topics9
NLM's MeSH indexing of the paper, its major topics first.
| MeSH term | Major |
|---|---|
| Calcitonin Gene-Related Peptide | Major topic |
| Receptors, Calcitonin Gene-Related Peptide | Major topic |
| Humans | |
| Protein Binding | |
| Binding Sites | |
| Cyclic AMP | |
| HEK293 Cells | |
| Protein Domains | |
| Peptide Fragments |
Source PubMed
Grants2
Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.
| Grant, as the record writes it | Agency | Country | NIH project | Stated by | Source |
|---|---|---|---|---|---|
| R01 GM104251 | NIGMS NIH HHS | United States | R01GM104251 | PubMed and NIH | NIH RePORTER |
| R01 GM130794 | NIGMS NIH HHS | United States | R01GM130794 | PubMed and NIH | NIH RePORTER |
Trials0
The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.
None in this release.
Comments and corrections0
PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.
None in this release.
References64
The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.
| Order | PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|---|
| 1 | 25,982,113 | Structural Basis for Receptor Activity-Modifying Protein-Dependent Selective Peptide Recognition by a G Protein-Coupled Receptor. | Mol Cell | 2015 | https://conductscience.org/library/papers/25982113 | PubMed |
| 2 | 18,946,036 | Prolonged signaling at the parathyroid hormone receptor by peptide ligands targeted to a specific receptor conformation. | Proc Natl Acad Sci U S A | 2008 | https://conductscience.org/library/papers/18946036 | PubMed |
| 3 | 36,546,772 | New Insights into the Structure and Function of Class B1 GPCRs. | Endocr Rev | 2023 | https://conductscience.org/library/papers/36546772 | PubMed |
| 4 | 10,856,900 | Identification of key components in the irreversibility of salmon calcitonin binding to calcitonin receptors. | J Endocrinol | 2000 | https://conductscience.org/library/papers/10856900 | PubMed |
| 5 | 19,084,002 | Examining the binding properties of MK-0974: a CGRP receptor antagonist for the acute treatment of migraine. | Eur J Pharmacol | 2009 | https://conductscience.org/library/papers/19084002 | PubMed |
| 6 | 30,209,400 | Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor. | Nature | 2018 | https://conductscience.org/library/papers/30209400 | PubMed |
| 7 | 16,888,652 | Drug-target residence time and its implications for lead optimization. | Nat Rev Drug Discov | 2006 | https://conductscience.org/library/papers/16888652 | PubMed |
| 8 | 33,602,864 | Structure and dynamics of the CGRP receptor in apo and peptide-bound forms. | Science | 2021 | https://conductscience.org/library/papers/33602864 | PubMed |
| 9 | 32,487,746 | Biochemical characterization of G protein coupling to calcitonin gene-related peptide and adrenomedullin receptors using a native PAGE assay. | J Biol Chem | 2020 | https://conductscience.org/library/papers/32487746 | PubMed |
| 10 | 11,693,189 | Receptor activity modifying proteins interaction with human and porcine calcitonin receptor-like receptor (CRLR) in HEK-293 cells. | Mol Cell Biochem | 2001 | https://conductscience.org/library/papers/11693189 | PubMed |
1 to 10 of 64
See all 64 referencesCited by2
The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 5 citations.
| PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|
| 42,220,511 | Immune remodeling and metabolic reprogramming in chronic fatigue: insights into GPCR signaling and epigenetic regulation. | Front Immunol | 2026 | https://conductscience.org/library/papers/42220511 | PubMed |
| 40,594,389 | Copper only SOD repeat proteins likely act as an extracellular superoxide dismutase in oyster antioxidant defense. | Sci Rep | 2025 | https://conductscience.org/library/papers/40594389 | PubMed |
Genes2
The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.
| Gene | NCBI Gene ID | Linked by | In Genes | Source |
|---|---|---|---|---|
| CALCA | 796 | PubTator's text mining | https://conductscience.org/library/genes/796 | NCBI Gene |
| CALCRL | 10,203 | PubTator's text mining | https://conductscience.org/library/genes/10203 | NCBI Gene |
Drugs0
The drugs whose trials, in the Pipelines release, list the paper.
None in this release.
Data0
The data bank entries PubMed's record names. Trial numbers are under Trials.
None in this release.
Data dates
The date of each source this release read.
- Trials
- 2026-11-12
- Gene search
- 2026-11-11
- Pipelines
- 2026-09-18
Sources 11
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- HGNCCC0
- iCiteCC BY 4.0
- NCBI GenePublic domain (US government)
- NIH RePORTER's grant and paper linksPublic domain
- Open TargetsCC0 1.0
- PMC's ID filePublic domain (US government)
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- HGNCCC0: https://www.genenames.org/about/license/
- iCiteCC BY 4.0
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
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