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Paper · 19240254

Downregulation of Grb2 contributes to the insulin-sensitizing effect of calorie restriction.

Liu X and 9 others. Am J Physiol Endocrinol Metab, 2009. Cited by 15 papers, by iCite.

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ConductScience Library. Downregulation of Grb2 contributes to the insulin-sensitizing effect of calorie restriction. Papers, record 19240254. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/19240254

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Downregulation of Grb2 contributes to the insulin-sensitizing effect of calorie restriction.
PubMed
Journal
Am J Physiol Endocrinol Metab
PubMed
Year
2009
PubMed
Publication types
Journal Article, Research Support, N.I.H., Extramural
PubMed
Citations, by iCite
15
iCite
Relative citation ratio, by iCite
0.35
iCite
Revised in PubMed
2021-10-20
PubMed

Authors10

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Liu XXianling
2Liu MMeilian
3Zhang JJingjing
4Bai XXiang
5Ramos FFresnida
6Van Remmen HHolly
7Richardson AArlan
8Liu FYFu-You
9Dong LQLily Q
10Liu FFeng

Source PubMed

Topics19

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Caloric RestrictionMajor topic
GRB2 Adaptor ProteinMajor topic
Insulin ResistanceMajor topic
Muscle, SkeletalMajor topic
1-Phosphatidylinositol 4-Kinase
Animals
Blotting, Western
Down-Regulation
Glucose Tolerance Test
Immunoprecipitation
Insulin
Insulin Receptor Substrate Proteins
Male
Mice
Mice, Knockout
Oncogene Protein v-akt
Phosphorylation
Signal Transduction
Tyrosine

Source PubMed

Grants1

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated by
R21-AG-26085NIA NIH HHSUnited StatesR21AG026085PubMed and NIH

Source NIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References39

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
112,799,317Brief calorie restriction increases Akt2 phosphorylation in insulin-stimulated rat skeletal muscle.Am J Physiol Endocrinol Metab2003https://conductscience.org/library/papers/12799317PubMed
210,404,938Calorie restriction in primates: will it work and how will we know?J Am Geriatr Soc1999https://conductscience.org/library/papers/10404938PubMed
312,417,588c-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade.J Biol Chem2003https://conductscience.org/library/papers/12417588PubMed
47,025,544Sensitivity of insulin secretion to feedback inhibition by hyperinsulinaemia.Acta Endocrinol (Copenh)1981https://conductscience.org/library/papers/7025544PubMed
510,464,095Gene expression profile of aging and its retardation by caloric restriction.Science1999https://conductscience.org/library/papers/10464095PubMed
612,424,796Lifespan extension by caloric restriction: an aspect of energy metabolism.Microsc Res Tech2002https://conductscience.org/library/papers/12424796PubMed
710,848,643Calorie restriction increases insulin-stimulated tyrosine phosphorylation of insulin receptor and insulin receptor substrate-1 in rat skeletal muscle.Acta Physiol Scand2000https://conductscience.org/library/papers/10848643PubMed
817,279,354C-reactive protein induces phosphorylation of insulin receptor substrate-1 on Ser307 and Ser 612 in L6 myocytes, thereby impairing the insulin signalling pathway that promotes glucose transport.Diabetologia2007https://conductscience.org/library/papers/17279354PubMed
915,855,319Akt2 is essential for the full effect of calorie restriction on insulin-stimulated glucose uptake in skeletal muscle.Diabetes2005https://conductscience.org/library/papers/15855319PubMed
1010,630,592Physiologic changes in humans subjected to severe, selective calorie restriction for two years in biosphere 2: health, aging, and toxicological perspectives.Toxicol Sci1999https://conductscience.org/library/papers/10630592PubMed

1 to 10 of 39

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Cited by12

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 15 citations.

PMIDTitleJournalYearIn PapersSource
42,979,455The conformational-condensate code of GRB2: State switching, spatial organization, and therapeutic windows.Acta Pharm Sin B2026https://conductscience.org/library/papers/42979455PubMed
38,158,369Mechanosensing in Metabolism.Compr Physiol2023https://conductscience.org/library/papers/38158369PubMed
35,875,664Effect of Selenium Treatment on Central Insulin Sensitivity: A Proteomic Analysis in β-Amyloid Precursor Protein/Presenilin-1 Transgenic Mice.Front Mol Neurosci2022https://conductscience.org/library/papers/35875664PubMed
32,930,093SWELL1 regulates skeletal muscle cell size, intracellular signaling, adiposity and glucose metabolism.Elife2020https://conductscience.org/library/papers/32930093PubMed
29,053,802Docosahexaenoic Acid Supplementation in Pregnancy Modulates Placental Cellular Signaling and Nutrient Transport Capacity in Obese Women.J Clin Endocrinol Metab2017https://conductscience.org/library/papers/29053802PubMed
28,436,964SWELL1 is a regulator of adipocyte size, insulin signalling and glucose homeostasis.Nat Cell Biol2017https://conductscience.org/library/papers/28436964PubMed
25,096,499Genome-wide DNA methylation changes in skeletal muscle between young and middle-aged pigs.BMC Genomics2014https://conductscience.org/library/papers/25096499PubMed
24,744,907Diet-induced obesity in mice reduces placental efficiency and inhibits placental mTOR signaling.Physiol Rep2014https://conductscience.org/library/papers/24744907PubMed
24,442,855Early gene expression changes in skeletal muscle from SOD1(G93A) amyotrophic lateral sclerosis animal model.Cell Mol Neurobiol2014https://conductscience.org/library/papers/24442855PubMed
23,771,793Suppression of Grb2 expression improved hepatic steatosis, oxidative stress, and apoptosis induced by palmitic acid in vitro partly through insulin signaling alteration.In Vitro Cell Dev Biol Anim2013https://conductscience.org/library/papers/23771793PubMed

1 to 10 of 12

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Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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